Zambrano-Urbano JL, Ocampo-Chaparro JM, Montero L

Language: Spanish
References: 18
Page: 1-11
PDF size: 542.72 Kb.

ABSTRACT

Introduction: Weil syndrome is a serious form of the bacterial infection caused by the Leptospira bacterium; this is known as leptospirosis. This is characterized by multiple organ dysfunction; for example, the liver, kidney, muscles, of serous type, or the neurological system, in this case called neuroleptospirosis, which produces a very high mortality when adequate diagnosis and treatment are not provided.
Objective: To describe the clinical manifestations, complementary paraclinic practice and treatment of a patient with Weil syndrome, as a rare condition.
Clinical case: 23-year-old patient who presents with acute febrile syndrome associated with optic neuritis, chest pain, and paraclinical symptoms obviously consistent liver and cardiac involvement. The diagnosis of Weil syndrome is confirmed, specifically defined by neuroleptospirosis, pericarditis, and intrahepatic cholestasis.
Conclusions: Through a clinical case of Weil syndrome, the multisystem involvement of complications associated with leptospirosis is described, along with its unusual manifestations, such as neuroleptospirosis, pericarditis, and intrahepatic cholestasis.

REFERENCES

1. Picardeau M. Diagnosis and epidemiology of leptospirosis. Médecine Mal Infect. 2013;43(1):1-9.

2. Carreño LA, Salas D, Beltrán KB. Prevalencia de leptospirosis en Colombia: Revisión sistemática de literatura. Rev Salud Pública. 2017;19(2):204-9.

3. Maroun E, Kushawaha A, El-Charabaty E, Mobarakai N, El-Sayegh S. Fulminant Leptospirosis (Weil's disease) in an urban setting as an overlooked cause of multiorgan failure: a case report. J Med Case Rep. 2011;14:5-7.

4. Quintanilla J, Richmond J, Gourgzong C. Leptospirosis y sindrome de Weil. Rev méd Costa Rica Centroam. 2004;71(566):3-9.

5. Puca E, Stroni G, Qyra E. Pericarditis as a Rare Complication of Severe Leptospirosis. Trop Med Surg. 2015;03(03):200-215.

6. Yesilbas O, Kihtir H, Yildirim H, Hatipoglu N, Sevketoglu E. Pediatric Fulminant Leptospirosis Complicated by Pericardial Tamponade, Macrophage Activation Syndrome and Sclerosing Cholangitis. Balkan Med J. 2016;33(5):578-80.

7. Modesto V, Medeiros U, Gomez D. Anicteric leptospirosis with pneumonitis, pericarditis and acalculous cholecystitis. Infez Med. 2014;22(3):236-40.

8. Bharti A, Nally J, Ricaldi J, Matthias M, Diaz M, Lovett M, et al. Leptospirosis: a zoonotic disease of global importance. Lancet Infect Dis. 2003;3(12):757-71.

9. Costa F, Hagan J, Calcagno J, Kane M, Torgerson P, Martinez-Silveira M, et al. Global Morbidity and Mortality of Leptospirosis: A Systematic Review. Small PLC, editor. PLoS Negl Trop Dis. 2015;9(9):e0003898.

10. Sakellaridis N, Panagopoulos D, Androulis A. Neuroleptospirosis with Hydrocephalus and Very Elevated Cerebrospinal Fluid Protein. Southern Medical Journal. 2009;102(5):549-550.

11. Rathinam S, Rathnam S, Selvaraj S, Dean D, Nozik R, Namperumalsamy P. Uveitis associated with an epidemic outbreak of leptospirosis. Am J Ophthalmol. 1997;124(1):71-9.

12. Wang N, Han Y, Sung J, Lee W, Ou T. Atypical leptospirosis: an overlooked cause of aseptic meningitis. BMC Res Notes. 2016;9(1):154.

13. Marra CM. Neurosyphilis. Contin Lifelong Learn Neurol. 2015;21(6):1714-28.

14. Panicker J, Mammachan R, Jayakumar R. Primary neuroleptospirosis. Postgrad Med J. 2001;77(911):589-90.

15. Lelis S, Fonseca L, Xavier C, Horta M, Cordeiro S. Acute Disseminated Encephalomyelitis After Leptospirosis. Pediatr Neurol. 2009;40(6):471-3.

16. Niraj S, Shah AB, Coplan N, Kronzon I. Acute Pericarditis. Prog Cardiovasc Dis. 2017;59(4):349-59.

17. De Brito T, Silva A, Abreu P. Pathology and pathogenesis of human leptospirosis: a commented review. Rev Inst Med Trop Sao Paulo. 2018;60(0):e23.

18. Imazio M, Gaita F, LeWinter M. Evaluation and Treatment of Pericarditis. JAMA. 2015;314(14):1498.