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2020, Number 3

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Rev Cubana Invest Bioméd 2020; 39 (3)

Necropsic finding of nephroblastoma associated to experimental metabolic syndrome

García-Gómez ML, González-Madariaga Y, Llerena-Bernal T

Language: Spanish
References: 34
Page: 1-14
PDF size: 541.15 Kb.


ABSTRACT

Introduction: One of the manifestations of metabolic syndrome is obesity, which is in turn related to the development of cancer. However, in four years we had not found any case of malignant neoplasms in animals with metabolic syndrome.
Objective: Describe the development of a malignant renal tumor in an experimental metabolic syndrome model.
Methods: The experimental biomodel was made applying a 35% saccharose solution to 50 male weaned Wistar rats for 20 weeks. The diagnosis of nephroblastoma was achieved by necropsy with morphological observation of the renal lesion.
Results: Upon metabolic syndrome confirmation, a palpable mass was detected in the abdomen of one of the cases. Macroscopic observation revealed a grayish brown tumor in the lower pole of the right kidney with hemorrhaging and cystic changes. Histological examination found alterations typical of mixed nephroblastoma with blastema, mesenchymal and epithelial components.
Conclusions: This is the first time a description is provided in an anatomopathological study of a case of nephroblastoma in a rat with experimental metabolic syndrome.


REFERENCES

  1. Khandekar M, Cohen P, Spiegelman B. Molecular mechanisms of cancer development in obesity. Nat Rev Cancer. 2011;11:886-95.

  2. Oh S, Park C, Lee E, Yoon Y, Lee E, Park S, et al. Adipokines, insulin resistance, metabolic syndrome, and breast cancer recurrence: a cohort study. Breast Cancer Res. 2011;13(2):R34-44.

  3. Cone E, Van Noord M, Tracy E, Rice H, Routh J. Biomarkers for Wilms tumor: a systematic review. The Journal of Urology. 2016;196(5):1530-5.

  4. Silva M, Molinari F, Fornari J, Barnabé A, Cordeiro S, Lima A, et al. Descrição de Casos de Nefroblastoma Diagnosticados em um Laboratório de Anatomia Patológica da Cidade de São Paulo, Brasil. Revista Brasileira de Cancerologia. 2013;59(2):185-91.

  5. Estrada S. Incidencia y distribución de tumores sólidos malignos en niños de 0-15 años, según tipo histológico, edad y género. Revista Venezolana de Salud Pública. 2014;2(2):29-34.

  6. Concepción A, Peralta E, Vaillant T, Jordá D, Fernández R, Jackson E. Descripción clínico genética de pacientes con tumor de Wilms. Panorama Cuba y Salud. 2014;5(4):29-32.

  7. Martínez R, Labrada E, Vialat V, Vázquez E. Tumores retroperitoneales en la infancia. Revista Cubana de Pediatría. 2015;87:14-20.

  8. Iglesias P, Durbá A, Caraballo L, Guill J, Martín I, Hinarejos C, et al. Nefroblastoma. Experiencia a largo plazo en el abordaje multidisciplinario. Cir Pediatr. 2018;31:46-51.

  9. Robbins S, Cotran R, Kumar V, Collins T. Patología estructural y funcional. 9na ed. Madrid: McGrau-Hill; 2015.

  10. Kumar S, Lupo P, Pompeii L, Danysh H. Maternal Residential Proximity to Major Roadways and Pediatric Embryonal Tumors in Offspring. International Journal of Environmental Research and Public Health. 2018;15(3):505.

  11. Pérez M, Betancourt S, Fernández M. Factores de riesgo modificables en algunos tipos de cáncer. Revista Electrónica Dr Zoilo E Marinello Vidaurreta. [revista en internet]. 2016 [citado 19/05/2020];41(11): 1-10. Disponible en http://www.revzoilomarinello.sld.cu/index.php/zmv/article/view/940

  12. Deng C, Dai R, Li X, Liu F. Genetic variation frequencies in Wilms' tumor: A meta-analysis and systematic review. Cancer science. 2016;107(5):690-9.

  13. Kirschner K, Braun J, Jacobi C, Rudigier L, Persson A, Scholz H. Amine oxidase copper containing 1 (AOC1) is a downstream target gene of the Wilms tumor protein, WT1, during kidney development. Journal of Biological Chemistry. 2014;289(35):24452-62.

  14. Rafiq S, Purdon T, Daniyan A, Koneru M, Dao T, Liu C, et al. Optimized T-cell receptor-mimic chimeric antigen receptor T cells directed toward the intracellular Wilms Tumor 1 antigen. Leukemia. 2017;31(8):1788-97.

  15. Cherñawsky D, MLL S, Gómez R. Bases moleculares del desarrollo renal. Arch Latin Nefr Ped. 2002;2(1):13-29.

  16. Iyengar N, Gucalp A, Dannenberg A, Hudis C. Obesity and cancer mechanisms: tumor microenvironment and inflammation. Journal of Clinical Oncology. 2016;34(35):4270-6.

  17. Deng T, Lyon C, Bergin S, Caligiuri M, Hsueh W. Obesity, inflammation, and cancer. Annual Review of Pathology: Mechanisms of Disease. 2016;11:421-49

  18. Uzunlulu M, Caklili O, Oguz A. Association between metabolic syndrome and cancer. Annals of Nutrition and Metabolism. 2016;68(3):173-9.

  19. Blancas-Flores G, Almanza-Pérez J, López-Roa R, Alarcón-Aguilar F, García-Macedo R, Cruz M. La obesidad como un proceso inflamatorio. Boletín Médico del Hospital Infantil de México. 2010;67(2):88-97.

  20. Divella R, De Luca R, Abbate I, Naglieri E, Daniele A. Obesity and cancer: the role of adipose tissue and adipo-cytokines-induced chronic inflammation. Journal of Cancer. 2016;15(7):2346-59.

  21. Herrera-Covarrubias D, Coria-Avila G, Fernández-Pomares C, Aranda-Abreu G, Manzo Denes J, Hernández M. La obesidad como factor de riesgo en el desarrollo de cáncer. Rev Perú Med Exp Salud Pública. 2015;32(4):766-76.

  22. Weisberg S, McCann D, Desai M, Rosenbaum M, Leibel R, Ferrante A. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112(12):1796-808.

  23. Lennon H, Sperrin M, Badrick E, Renehan A. The obesity paradox in cancer: a review. Current Oncology Reports. 2016;9 (18):1-8.

  24. O'Neill S, O'Driscoll L. Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies. Obesity Reviews. 2015;16(1):1-12.

  25. Chehval V, Norian L. Effects of obesity on immune responses to renal tumors. Immunologic Research. 2014;59(1-3):211-9.

  26. Council NR. Guide for the Care and use of laboratory animals. 8th ed. Washington, DC. The National Academies Press; 2001.

  27. Close B, Banister K, Baumans V, Bernoth E, Bromage N, Bunyan J, et al. Recommendations for the euthanasia of experimental animals. Lab Animal. 1997;31(1):1-32.

  28. González-Madariaga Y, Castillo-Alfonso O, Llerena-Bernal T, Alfonso-Perdomo O, de la Barca-Barrera M, González-Machado Y. Síndrome metabólico en ratas Wistar inducido por dieta rica en sacarosa. Acta Bioquímica Clínica Latinoamericana. 2015;49(3):301-9

  29. Alberti KGMM, Zimmet P, Shaw J. Metabolic syndrome -a new world-wide definition. A consensus statement from the International Diabetes Federation. Diabetic Medicine. 2006;23(5): 469-80.

  30. Caicedo P, Perdomo A, Sandoval D, Betancourt C, Jiménez Y, Zamudio G, et al. Tumor de Wilms en adultos: reporte de un caso. Revista Urología Colombiana. 2012;21(1):79-83.

  31. Ehrlich P, Chi Y, Chintagumpala M, Hoffe rF, Perlman E, Kalapurakal J, et al. Results of the first prospective multi-institutional treatment study in children with bilateral Wilms tumor (AREN0534): a report from the Childrens Oncology Group. Annals of Surgery. 2017;266(3):470-8.

  32. Gacci M, Russo G, De Nunzio C, Sebastianelli A, Salvi M, Vignozzi L, et al. Meta-analysis of metabolic syndrome and prostate cancer. Prostate cancer and prostatic diseases. 2017;20(2):146.

  33. Kitson S, Lindsa yJ, Sivalingam V, Rutter M, Crosbie E. High prevalence of metabolic syndrome in women newly diagnosed with endometrial cancer. Gynecologic Oncology Reports. 2018;26:109-10.

  34. Salazar M, González H, Sánchez N, Lira A, Roque H, Castañón M, et al. Asociación del cáncer de mama con síndrome metabólico y estado nutricional en mujeres en querétaro, México Actualización en Nutrición. 2016;17(4):102-8.




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