2021, Number 4
<< Back Next >>
Rev Fac Med UNAM 2021; 64 (4)
How to suspect patients with innate immunity errors at the first level of care?
Mondragón PAI, Scheffler MSC
Language: Spanish
References: 8
Page: 41-46
PDF size: 241.25 Kb.
ABSTRACT
Currently there are 430 primary immunodeficiencies (PIDs)
also called innate immunity errors, resulting from more than
320 identified mutations, which together affect at least 1 in
500 live newborns and are therefore no longer considered
rare diseases.
Many doctors do not suspect these pathologies, which
generates delay in diagnosis and treatment, generating a
poor prognosis for life quality and death, for which reason
the objective of this article is to transmit the key points for
their suspicion and reference to a specialized center.
REFERENCES
Aghamohammadi A, Abolhassani H, Kutukculer N, Wassilak S. Patients with Primary Immunodeficiencies Are a Reservoir of Poliovirus and a Risk to Polio Eradication. Frontiers of Immunology. 2017 Jun 13;8:685.
Tangye S, Al-Herz W, Bousfiha A. Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee. Journal of Clinical Immunology. 2020:4:24-64.
Modell V, Orange J, Quinn J. Global report on primary immunodeficiencies: 2018 update from the Jeffrey Modell Centers Network on disease classification, regional trends, treatment modalities, and physician reported outcomes. Immunologic Research. 2018:66(3):367-380.
Hughes H, Kahl L. Manual Harriet Lane de Pediatría. Vigésima primera edición. Elsevier: 2018.
Condino-Neto A, Sorensen R, Gómez Raccio A, King A. Current state and future perspectives of the Latin American Society for Immunodeficiencies (LASID). Allergologia et immunopathologia. Sep-Oct 2015;43(5):493-7.
Costa-Carvalho B, González-Serrano M, Espinosa Padilla S, Segundo G. Latin American Challenges with the Diagnosis and Treatment of Primary Immunodeficiency Diseases. Expert Review of Clinical Immunology. 2017 May;13(5):483-489.
Bustamante JC, Partida A, Aldave JC, Álvarez A. Latin American consensus on the supportive management of patients with severe combined immunodeficiency. Journal of allergy and Clinical Immunology. 2019 Oct;144(4):897- 905.
Seoane Reula ME, et al. Diagnóstico y manejo de las inmunodeficiencias primarias en niños. Protocolos diagnósticos y terapéuticos en pediatría. 2019;2:415-35.