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2002, Number 2

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Rev Endocrinol Nutr 2002; 10 (2)

Thiazolidinediones: Benefits and risks

Hernández-Jiménez S, Aguilar-Salinas CA, Gómez-Pérez FJ

Language: Spanish
References: 179
Page: 69-76
PDF size: 105.29 Kb.


ABSTRACT

Thiazolidinediones represent a new class of oral hypoglycemic agents with insulin sensitizing actions. In several trials, these agents have shown effects on lipid metabolism, cellular differentiation and some cardiovascular risk factors. In this paper, we review the literature and analyse, in clinical perspective some data about the benefits of this group of drugs in the control and prevention of diabetes in comparison to some other available agents. At present, we are still lacking information on the long-term benefits and risks of these drugs.


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  97. Cominacini L, Garbin U, Fratta Pasini A, Campagnola M, Davoli A, Foot E et al. Troglitazone reduces LDL oxidation and lowers plasma E-selectin concentration in NIDDM patients. Diabetes 1998; 47: 130-133.

  98. Tack CJ, Smits P, Demacker PN, Stalenhoef AF. Troglitazone decreases the proportion of small, dense LDL and increases the resistance of LDL to oxidation in obese subjects. Diabetes Care 1998; 21: 796-9.

  99. Hirano T, Yoshino Gm Kazumi T. Troglitazone and small lowdensity lipoprotein in type 2 diabetes. Ann Int Med 1998; 129 162-3.

  100. Law RE, Meehan WP, Xi XP, Graf K, Wuthrich DA, Coats W. Troglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia. J Clin Invest 1996; 98: 1897-1905.

  101. Yoshimoto T, Naruse M, Shizume H, Naruse K, Tanabe A, Tanaka M et al. Vasculo-protective effects of insulin sensitizing agent pioglitazone in neointimal thickening and hypertensive vascular hypertrophy. Atherosclerosis 1999; 145: 333-40.

  102. Collins AR, Meehan WP, Kintscher U, Jackson S, Wakino S, Noh G et al. Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 2001; 21: 365-71.

  103. Avena R, Mitchell ME, Nylen ES, Curry KM, Sidawy AN. Insulin action enhancement normalizes brachial artery vasoactivity in patients with peripheral vascular disease and occult diabetes. J Vasc Surg 1998; 28: 1024-1031.

  104. Hattori Y, Hattori S, Kasai K. Troglitazone upregulates nitric oxide synthesis in vascular smooth muscle cells. Hypertension 1999; 33(4): 943-8.

  105. Igarashi M, Takeda Y, Ishibashi N, Takahashi K, Mori S, Tominaga M, Saito Y. Pioglitazone reduces smooth muscle cell density of rat carotid arterial intima induced by balloon catheterization. Horm Metab Res 1997; 29: 444-449.

  106. Ishizuka T, Itaya S, Wada H, Ishizawa M, Kimura M, Kajita K et al. Differential effect of the antidiabetic thiazolidinediones troglitazone and pioglitazone on human platelet aggregation mechanism. Diabetes 1998; 47: 1494-1500.

  107. Kotchen TA, Zhang HY, Reddy S, Hoffmann RG. Effect of pioglitazone on vascular reactivity in vivo and in vitro. Am J Physiol 1996; 270: R660-R666.

  108. Law RE, Goetze S, Xi XP, Jackson S, Kawano Y, Demer L. Expression and function of PPARgamma in rat and human vascular smooth muscle cells. Circulation 2000; 101: 1311-8.

  109. Marx N, Schonbeck U, Lazar MA, Libby P, Plutzky J. Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells. Circ Res 1998; 83: 1097-1103.

  110. Walker AB, Chattington PD, Buckingham RE, Williams G. The thiazolidinedione rosiglitazone (BRL-49653) lowers blood pressure and protects against impairment of endothelial function in Zucker fatty rats. Diabetes 1999; 48: 1448-1453.

  111. Yamakawa K, Hosoi K, Fukumoto S, Koyama H, Okuno Y, Nishizawa Y. Pioglitazone inhibits plasminogen activator inhibitor- 1 expression in human vascular smooth muscle cell. Diabetes 1998; 47: A366. Abstract.

  112. Arima S, Kohagura K, Takeuchi K et al. Biphasic vasodilator action of troglitazone on the renal microcirculation. J Am Soc Nephrol 2002; 13(2): 342-9.

  113. Yamashita H, Nagai Y, Takamura T, Nohara E, Kobayashi Ki K. Thiazolidinedione derivatives ameliorate albuminuria in streptozotocin- induced diabetic spontaneous hypertensive rat. Metabolism 2002; 51(4): 403-8.

  114. Malinowski JM, Bolesta S. Rosiglitazone in the treatment of type 2 diabetes mellitus: a critical review. Clin Ther 2000; 22(10): 1151-68; discussion 1149-50.

  115. Goldstein BJ. Differentiating members of the thiazolidinedione class: a focus on efficacy. Diabetes Metab Res Rev 2002; 18 Suppl 2: S16-22.

  116. Temple R, Ellenberg SS. Placebo-Controlled Trials and Active- Control Trials in the Evaluation of New Treatments. Part 1: Ethical and Scientific Issues. Ann Intern Med 2000; 133: 455-63.

  117. Cavaghan MK, Ehrmann DA, Byrne MM, Polonsky S. Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance. J Clin Invest 1997; 100: 530-7.

  118. Berkowitz K, Peters R, Kjos SL, Goico J, Marroquin A, Dunn ME, Xiang A, Azen S, Buchanan TA. Effect of troglitazone on insulin sensitivity and pancreatic B-cell function in women at high risk for non-insulin-dependent diabetes mellitus. Diabetes 1996; 45: 1572-1579.

  119. Azen SP, Berkowitz K, Kjos S, Peters R, Xiang A, Buchanan TA. TRIPOD: A randomized placebo-controlled trial of troglitazone in women with prior gestational diabetes mellitus. Control Clinical Trials 1998; 19:217-231.

  120. The Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Eng J Med 2002; 346: 393-403.

  121. Chu NV, Kong AP, Kim D, Armstrong D, Baxi S, Deutsch R et al. Differential effects of metformin and troglitazone on cardiovascular risk factors in patients with type 2 diabetes. Diabetes Care 2002; 25: 542-48.

  122. Kumar S, Boulton AJM, Beck-Nielsen H et al. Troglitazone, an insulin action enhancer, improves metabolic control in NIDDM patients. Diabetología 1996; 39: 701-9.

  123. Iwamoto I, Kosaka K, Kuzuya Y, Akanuma Y, Shigeta Y, Kaneko T. Effects of troglitazone: a new hypoglycemic agent in patients with NIDDM poorly controlled by diet therapy. Diabetes Care 1996; 19: 151-6.

  124. Antonucci T, Whitcomb R, McLain R, Lockwood D. Impaired glucose tolerance is normalized by treatment with the thiazolidinedione troglitazone. Diabetes Care 1997; 20: 188-93.

  125. Maggs DG, Buchanan TA, Burant Ch, Cline G, Gumbiner B, Hsueh WA. Metabolic Effects of Troglitazone Monotherapy in Type 2 Diabetes Mellitus. Ann Intern Med 1998; 128: 176-185.

  126. Subramaniam S. The emerging role of thiazolidinediones in the treatment of diabetes- mellitus and related disorders. Clin Exp Hypertens 1999; 21(1-2): 121-36.

  127. Inzucchi SE, Maggs DG, Spollett GR, Page SL, RifeFS, Walton V, Shulman GI. Efficacy and metabolic effects of metformin and troglitazone in type 2 diabetes. NEJM 1998; 338: 867-72.

  128. Fonseca V, Rosenstock J, Patwardhan R, Salzman A. Effect of metformin and rosiglitazone combination therapy in patients with type 2 diabetes mellitus: a randomized controlled trial. JAMA 2000; 283: 1695-1702.

  129. Raskin P, Rappaport EB, Cole ST, Yan Y, Patwardhan R, Freed MI. Rosiglitazone short-term monotherapy lowers fasting and post-prandial glucose in patients with type II diabetes. Diabetologia 2000; 43: 278-84.

  130. Gale EA. Lessons from the glitazones: a story of drug development. Lancet 2001; 357: 1870-75

  131. Kobayashi M, Iwata M, Haruta T. [Clinical evaluation of pioglitazone]. Nippon Rinsho 2000; 58(2): 395-400.

  132. Lawrence JM, Reckless JP. Pioglitazone. Int J Clin Pract 2000; 54(9): 614-8.

  133. Yamasaki Y, Kawamori R, Wasada T et al. Pioglitazone (AD- 4833) ameliorates insulin resistance in patients with NIDDM. AD-4833 Glucose Clamp Study Group, Japan. Tohoku J Exp Med 1997; 183: 173-83.

  134. Aronoff S, Rosenblatt S, Braithwhite S et al. Pioglitazone hydrochloride monotherapy improves glycemic control in the treatment of patients with type 2 diabetes: a 6-month randomized placebo-controlled dose-response study. Diabetes Care 2000; 23: 1605.

  135. Ghazzi MN, Perez JE, Antonucci TK et al. Cardiac and glycemic benefits of troglitazone treatment in NIDDM. The Troglitazone Study Group. Diabetes 1997; 46(3): 433-9.

  136. Khan MA, St Peter JV, Xue JL. A prospective, randomized comparison of the metabolic effect of pioglitazone or rosiglitazone in patients with type 2 diabetes who were previously treated with troglitazone. Diabetes Care 2002; 25: 708-711.

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