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2021, Number 2

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Rev Cent Dermatol Pascua 2021; 30 (2)

The role of the intestinal microbiota in atopic dermatitis

Rodarte-Acosta JS, Morales-Sánchez MA

Language: Spanish
References: 60
Page: 76-83
PDF size: 333.64 Kb.


ABSTRACT

The intestinal microbiota is defined as the collection of microbes (bacteria, fungi, archaea, and viruses) that inhabit the human intestine. The gastrointestinal tract shelters approximately 1014 microbes. The gastrointestinal microbiota is essential for the maturation of the immune system, composed of both adaptive and innate immune responses. Changes in microbial composition and function are called dysbiosis; dysbiosis has been observed in the pathogenesis of metabolic disorders, cancer, and non-intestinal and dermatological autoimmune diseases such as atopic dermatitis, psoriasis, and alopecia areata. Atopic dermatitis (AD) is a chronic, autoimmune disease that affects 15% of the children, there is a possible interaction between microbes and atopic dermatitis according to the hygiene hypothesis. Intestinal dysbiosis affects the cutaneous immune response in a way that children are predisposed to a number of immune conditions, capable of triggering immune activation and the release of cytokines involved in the subsequent development of clinical signs of AD. It is still debated whether an altered gut barrier facilitates a broader spectrum of hypersensitization disorders, such as AD, however, understanding the gut microbiota in immune-mediated dermatoses could suggest additional treatments in addition to conventional therapies.


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