Pizarro AG, Garnier FJC, Orozco GR

Language: Spanish
References: 16
Page: 5-8
PDF size: 196.70 Kb.

ABSTRACT

Encephalitis is an inflammation of the brain parenchyma associated with neurological dysfunction. It usually presents as acute or subacute, with altered mental status greater than 24 hours, fever, seizures, headache, and/or focal neurologic deficits.
Herpes simplex virus type 1 is the most common non-epidemic cause of infectious encephalitis, and Japanese encephalitis is the most common cause of infectious encephalitis worldwide. The cornerstone for diagnosis is based on performing a lumbar puncture in which lymphocytic pleocytosis is observed and a PCR should be requested urgently.
Treatment is based on support measures ensuring oxygenation, airway protection, circulatory support, treatment of pyrexia and it is recommended to start empirically with intravenous acyclovir.

REFERENCES

1. Venkatesan A, Michael BD, Probasco JC, Geocadin RG, Solomon T. Acute encephalitis in immunocompetent adults. The Lancet. febrero de 2019;393(10172):702-16.

2. Bradshaw MJ, Venkatesan A. Herpes Simplex Virus-1 Encephalitis in Adults: Pathophysiology, Diagnosis, and Management. Neurotherapeutics. julio de 2016;13(3):493-508

3. Bertrand A, Leclercq D, Martinez-Almoyna L, Girard N, Stahl J-P, De-Broucker T. MR imaging of adult acute infectious encephalitis. Médecine Mal Infect. mayo de 2017;47(3):195-205.

4. Beaman MH. Community‐acquired acute meningitis and encephalitis: a narrative review. Med J Aust. noviembre de 2018;209(10):449-54.

5. Gnann JW, Whitley RJ. Herpes Simplex Encephalitis: an Update. Curr Infect Dis Rep. marzo de 2017;19(3):13.

6. Kumar R. Understanding and managing acute encephalitis. F1000Research. 29 de enero de 2020;9:60.

7. Tyler KL. Acute Viral Encephalitis. Ropper AH, editor. N Engl J Med. 9 de agosto de 2018;379(6):557-66.

8. Rabinstein AA. Herpes Virus Encephalitis in Adults. Neurol Clin. noviembre de 2017;35(4):695-705.

9. Venkatesan A, Murphy OC. Viral Encephalitis. Neurol Clin. noviembre de 2018;36(4):705-24.

10. Klein RS. Herpes simplex virus type 1 encephalitis. :21.

11. Halperin JJ. Diagnosis and management of acute encephalitis. En: Handbook of Clinical Neurology [Internet]. Elsevier; 2017 [citado 22 de mayo de 2021]. p. 337-47. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/B9780444636003000180

12. Bookstaver PB, Mohorn PL, Shah A, Tesh LD, Quidley AM, Kothari R, et al. Management of Viral Central Nervous System Infections: A Primer for Clinicians. J Cent Nerv Syst Dis. 1 de enero de 2017;9:117957351770334.

13. Gluckman SJ. Viral encephalitis in adults. :22.

14. Ellul M, Solomon T. Acute encephalitis – diagnosis and management. Clin Med. abril de 2018;18(2):155-9.

15. Stahl JP, Mailles A. Herpes simplex virus encephalitis update: Curr Opin Infect Dis. junio de 2019;32(3):239-43.

16. León Alvarado LJ, Franco Olivo NS, Sánchez Acebo JA, Borja Viteri MA. Manejo de la encefalitis y la meningitis. RECIAMUC. 30 de enero de 2021;5(1):368-81.