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Federación Mexicana de Ginecología y Obstetricia, A.C.

2021, Number 08

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Ginecol Obstet Mex 2021; 89 (08)

Risk combination: COVID-19 and preeclampsia. Case series and literature review

Martínez-González B, Garza-Reséndez N, Contreras-Garza NY, González-Oropeza D

Language: Spanish
References: 35
Page: 622-634
PDF size: 222.17 Kb.


ABSTRACT

Objective: To present cases of pregnant women with COVID-19 and preeclampsia that showed torpid evolution and unfavorable outcomes. As well as a review of the literature to know the prevalence of both pathologies and their similarities, to be able to differentiate them and to evaluate the most appropriate management.
Material and Method: An electronic search was performed in databases, finding 120 articles, of which a total of 33 articles were included for the literature review.
Results: We report four cases of patients diagnosed with COVID-19 infection and preeclampsia who presented torpid evolutions with complications such as eclampsia, stroke, HELLP syndrome, acute kidney injury, DIC, pneumonia, maternal death and fetal death. This shows that pregnant women with these two pathologies can present severe complications where morbidity and risk of death are high.
Conclusions: The presence of preeclampsia and COVID-19 represents a diagnostic challenge due to similar clinical, laboratory and pathophysiology data. PCR testing should be considered for all women with high-risk pregnancies and those presenting with symptoms suggestive of preeclampsia to avoid delay in diagnosis.


REFERENCES

  1. Yang H, Sun G, Tang F, Peng M, Gao Y, Peng J, et al. Clinical features and outcomes of pregnant women suspected of coronavirus disease 2019. J Infect 2020; 81 (1): e40-e44. https://doi.org/10.1016/j.jinf.2020.013.003

  2. Breslin N, Baptiste C, Gyamfi-Bannerman C, Miller R, Martinez R, Bernstein K, et al. COVID-19 infection among asymptomatic and symptomatic pregnant women: Two weeks of confirmed presentations to an affiliated pair of New York City hospitals Noelle. Am J Obstet Gynecol MFM 2020. https://covid-19.conacyt.mx/jspui/handle/1000/2187

  3. Lei S, Jiang F, Su W, Chen C, Chen J, Mei W, et al. Clinical characteristics and outcomes of patients undergoing surgeries during the incubation period of COVID-19 infection. EClinicalMedicine 2020; 21: 100331. https://doi. org/10.1016/j.eclinm.2020.100331

  4. World Health Organization. Weekly Operational Update on COVID-19 May 10, 2021. World Heal Organ 2021; (Health Emergencies Programme): 1-15. https://www.who.int/ publications/m/item/weekly-operational-update-oncovid- 19---10-may-2021

  5. Verma S, Carter EB, Mysorekar IU. SARS-CoV2 and pregnancy: An invisible enemy? Am J Reprod Immunol 2020; 84 (5): 0-3. https://doi.org/10.1111/aji.13308

  6. Vlachodimitropoulou Koumoutsea E, Vivanti AJ, Shehata N, Benachi A, Le Gouez A, Desconclois C, et al. COVID-19 and acute coagulopathy in pregnancy. J Thromb Haemost 2020; 18 (7): 1648-52. https://doi.org/10.1111/jth.14856

  7. Golden TN, Simmons RA. Maternal and neonatal response to COVID-19. Am J Physiol Endocrinol Metab 2020; 319 (2): E315-9. https://doi.org/10.1152/ajpendo.00287.2020

  8. Hosier H, Farhadian SF, Morotti RA, Deshmukh U, Lu- Culligan A, Campbell KH, et al. SARS-CoV-2 infection of the placenta. J Clin Invest 2020; 130 (9): 4947-53. doi: 10.1172/JCI139569

  9. GidLöf S, Savchenko J, Brune T, Josefsson H. COVID-19 in pregnancy with comorbidities: More liberal testing strategy is needed. Acta Obstet Gynecol Scand 2020; 0-2. http:// www.ncbi.nlm.nih.gov/pubmed/32249924

  10. Hantoushzadeh S, Shamshirsaz A, Aleyasin A, Seferovic M, Kazemi S. Maternal death due to COVID-19. Am J Obstet Gynecol 2020; 2507 (1): 1-9. https://doi.org/10.1016/j. ajog.2020.04.030

  11. Dap M, Morel O. Proteinuria in Covid-19 pregnant women: Preeclampsia or severe infection? Eur J Obstet Gynecol Reprod Biol 2020; 252. https://doi.org/10.1016/j.ejogrb. 2020.07.005

  12. Ahmed I, Eltaweel N, Antoun L, Rehal A. Severe pre-eclampsia complicated by acute fatty liver disease of pregnancy, HELLP syndrome and acute kidney injury following SARSCoV- 2 infection. BMJ Case Rep 2020; 13 (8): 2-4. http:// dx.doi.org/10.1136/bcr-2020-237521

  13. Organización Panamericana de la Salud / Organización Mundial de la Salud. Alerta Epidemiológica: COVID-19 en el embarazo, 13 de agosto de 2020, Washington, DC. OPS/OMS. 2020. https://www.paho.org/es/documentos/ alerta-epidemiologica-covid-19-durante-embarazo- 13-agosto-2020

  14. Rolnik DL. Can COVID-19 in pregnancy cause pre-eclampsia? BJOG An Int J Obstet Gynaecol 2020; 127 (11): 1381. https://doi.org/10.1111/1471-0528.16369

  15. Mendoza M, Garcia-Ruiz I, Maiz N, Rodo C, Garcia-Manau P, Serrano B, et al. Pre-eclampsia-like syndrome induced by severe COVID-19: a prospective observational study. BJOG An Int J Obstet Gynaecol 2020; 127 (11): 1374-80. https:// doi.org/10.1111/1471-0528.16339

  16. Narang K, Enninga EAL, Gunaratne MDSK, Ibirogba ER, Trad ATA, Elrefaei A, et al. SARS-CoV-2 Infection and COVID-19 During Pregnancy: A Multidisciplinary Review. Mayo Clin Proc 2020; 95 (8): 1750-865. https://doi.org/10.1016/j. mayocp.2020.05.011

  17. de Souza Silva GA, da Silva SP, da Costa MAS, da Silva AR, de Vasconcelos Alves RR, Ângelo Mendes Tenório F das C, et al. SARS-CoV, MERS-CoV and SARS-CoV-2 infections in pregnancy and fetal development. J Gynecol Obstet Hum Reprod 2020; 49 (10). https://doi.org/10.1016/j. jogoh.2020.101846

  18. Hansen JN, Hine J, Strout TD. COVID-19 and preeclampsia with severe features at 34-weeks gestation. Am J Emerg Med 2021; 39: 252.e3-252.e5. https://doi.org/10.1016/j. ajem.2020.06.052

  19. Futterman I, Toaff M, Navi L, Clare CA. Covid-19 and hellp: Overlapping clinical pictures in two gravid patients. AJP Rep 2020; 10 (2): E179-82. doi: 10.1055/s-0040-1712978

  20. Singh S. Coronavirus disease-2019 in pregnancy with neurological manifestations versus pregnancy with eclampsia: Need for liberal testing to rule out the masquerades. Acta Obstet Gynecol Scand 2020; 99 (7): 950. https://doi. org/10.1111/aogs.13927

  21. Ronnje L, Länsberg JK, Vikhareva O, Hansson SR, Herbst A, Zaigham M. Complicated COVID-19 in pregnancy: A case report with severe liver and coagulation dysfunction promptly improved by delivery. BMC Pregnancy Childbirth 2020; 20 (1): 1-8. https://doi.org/10.1186/s12884-020- 03172-8

  22. Shanes ED, Mithal LB, Otero S, Azad HA, Miller ES, Goldstein JA. Placental Pathology in COVID-19. Am J Clin Pathol 2020; 154 (1): 23-32. https://doi.org/10.1093/ajcp/aqaa089

  23. Di Mascio D, Khalil A, Saccone G, Rizzo G, Buca D, Liberati M, et al. Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis. Am J Obstet Gynecol MFM 2020; 2 (2): 100107. https://doi.org/10.1016/j.ajogmf.2020.100107

  24. Antoun L, Taweel N El, Ahmed I, Patni S, Honest H. Maternal COVID-19 infection, clinical characteristics, pregnancy, and neonatal outcome: A prospective cohort study. Eur J Obstet Gynecol Reprod Biol 2020; 252 (2019): 559-62. https://doi. org/10.1016/j.ejogrb.2020.07.008

  25. Dang D, Wang L, Zhang C, Li Z, Wu H. Potential effects of SARS-CoV-2 infection during pregnancy on fetuses and newborns are worthy of attention. J Obstet Gynaecol Res 2020; 46 (10): 1951-7. https://doi.org/10.1111/jog.14406

  26. Brandt JS, Hill J, Reddy A, Schuster M, Patrick HS, Rosen T, et al. Epidemiology of coronavirus disease 2019 in pregnancy: risk factors and associations with adverse maternal and neonatal outcomes. Am J Obstet Gynecol 2021; 224 (4): 389.e1-389.e9. https://doi.org/10.1016/j. ajog.2020.09.043

  27. Garcia Rodriguez A, Marcos Contreras S, Fernandez Manovel SM, Marcos Vidal JM, Diez Buron F, Fernandez Fernandez C, et al. SARS-COV-2 infection during pregnancy, a risk factor for eclampsia or neurological manifestations of COVID-19? Case report. BMC Pregnancy Childbirth 2020; 20 (1):2-4. https://doi.org/10.1186/s12884-020-03275-2

  28. Abbas AM, Ahmed OA, Shaltout AS. COVID-19 and maternal pre-eclampsia: A synopsis. Scand J Immunol 2020; 92 (3): 0-2. https://doi.org/10.1111/sji.12918

  29. Bloise E, Zhang J, Nakpu J, Hamada H, Dunk CE, Li S, et al. Expression of severe acute respiratory syndrome coronavirus 2 cell entry genes, angiotensin-converting enzyme 2 and transmembrane protease serine 2, in the placenta across gestation and at the maternal-fetal interface in pregnancies complicated by preterm. Am J Obstet Gynecol 2021; 224 (3): 298.e1-298.e8. https://doi.org/10.1016/j. ajog.2020.08.055

  30. Coronado-Arroyo JC, Concepción-Zavaleta MJ, Zavaleta- Gutiérrez FE, Concepción-Urteaga LA. Is COVID-19 a risk factor for severe preeclampsia? Hospital experience in a developing country. Eur J Obstet Gynecol Reprod Biol 2021; 256: 502-3. doi: 10.1016/j.ejogrb.2020.09.020

  31. Amorim MM, Takemoto MLS, Katz L. Re: Pre-eclampsialike syndrome induced by severe coronavirus disease 2019: a prospective observational study. BJOG An Int J Obstet Gynaecol 2020; 127 (12): 1577. https://doi. org/10.1111/1471-0528.16402

  32. Todros T, Masturzo B, De Francia S. COVID-19 infection: ACE2, pregnancy and preeclampsia. Eur J Obstet Gynecol Reprod Biol 2020; 253: 330. https://doi.org/10.1016/j. ejogrb.2020.08.007

  33. Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet 2020; 395 (10229): 1033- 4. http://dx.doi.org/10.1016/S0140-6736(20)30628-0

  34. Liu R, Ma Q, Han H, Su H, Liu F, Wu K, et al. The value of urine biochemical parameters in the prediction of the severity of coronavirus disease 2019. Clin Chem Lab Med 2020; 58 (7): 1121-4. doi: 10.1515/cclm-2020-0220

  35. Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic Manifestations of Hospitalized Patients with Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol 2020; 77 (6): 683-90. doi:10.1001/jamaneurol.2020.1127.




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