Paradoa PML, Andreu MHI, Pérez MOG

Language: Spanish
References: 26
Page: 46-50
PDF size: 271.59 Kb.

ABSTRACT

Common variable immunodeficiency (CVID) is the most common clinical primary immunodeficiency. It is characterized by defects in differentiation of B cells to plasma cells and memory B cells. The most important cellular alteration in CVID patients is severe B-cell deficiency. However, an alteration in the frequency and function of T cells has also been demonstrated in patients with CVID. Patients may also experience a wide variety of clinical complications, all of which are included in recent classifications of CVID into clinical phenotypes with different prognoses. A male patient aged 20, mestizo, with a history of bronchopneumonia, hepatosplenomegaly, chronic respiratory tract diseases and hypogammaglobulinemia, was diagnosed at 9 years old with CVID, in our service of Immunology, in the Pediatric Hospital “Juan Manuel Márquez”, Havana, Cuba. Other causes of this clinical picture were ruled out. The immunological tests showed: severe hypogammaglobulinemia with extremely low IgG, IgA and IgM levels as well as a decrease in CD3+CD4+ and CD19+ lymphocytes, with an increase in CD3+CD8+ lymphocytes. It was found an investment of the CD4+/CD8+ index. The blast transformation with Phytohemagglutinin, Concavalin A and mitogen powed were greatly diminished. The evaluation of the complement system showed normal results. The diagnosis of common variable immunodeficiency was made. After 10 years of evolutions has been evidence that treatment with intravenous immunoglobulin and transference factor produced in Cuba, produce reconstitution of normal values of IgG, elevation of CD4+ T-cell percentages, and improvement of T-cell proliferation.

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