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2003, Number 2

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Bioquimia 2003; 28 (2)

Study of reactivity to Toxoplasma gondii in pregnant women from Havana City and Pinar del Río Provinces, Cuba

Sánchez-Gutiérrez A, Martín-Hernández I, García-Izquierdo SM

Language: Spanish
References: 37
Page: 3-8
PDF size: 185.68 Kb.


ABSTRACT

Congenital toxoplasmosis may develop due to a maternal primary infection during pregnancy, which could cause serious sequelae to the newborn. Since toxoplasmosis in adults is usually asymptomatic, the only way to find pregnancies at risk of acute toxoplasmosis is to perform a serological screening of pregnant women. A prevalence study of anti- Toxoplasma gondii IgG antibodies in 1 210 Cuban pregnant women from Havana City and Pinar del Río, was carried out in order to determine the reactivity percents in each province, whether these percents vary depending on the geographical area studied, and if there is an increment in the reactivity to this parasite as the age increases. For this study the UMELISA Toxoplasma® assay was used and 61.82 % of reactivity to Toxoplasma gondii was found. 36.86% of the pregnant women from Havana City and 33.49% Pinar del Río presented antibody concentrations upper than 125 U/mL Besides, reactivity to Toxoplasma gondii in this population does not increase with age and the reactivity levels to anti-Toxoplasma gondii IgG antibodies in Pinar del Río (71%) were superior than in Havana City (52.35 %).


REFERENCES

  1. Kasper LH. Toxoplasma infection and toxoplasmosis. In:Harrinson’s Principles of Internal Medice.14 th ed. Singapure:McGraw-Hill. Inc Book Company; 1994.p. 903-908.

  2. Bobic B, Jevremovic I, Marinkovic J, Sibalic D, Djurkovic-Djakovic O. Risk factors for Toxoplasma infection in areproductive age female population in the area of Belgrade,Yugoslavia. Eur J Epidemiol 1998; 14 (6): 605-610.

  3. Nicolle C, Manceaux R. Coccidia Microsporidia y Pneumo-cystis. En: Parasitología Clínica. Clifton, CR y EC Wayne:Eds. Barcelona Salvat; 1986.p. 165-191.

  4. Botero D, Restrepo M. Toxoplasmosis. En: Parasitosis Hu-mana. 2da ed. Colombia: Corporación para Investigacio-nes Biológicas; 1992.p. 231-248.

  5. Benenson A. Toxoplasmosis congénita. En: El control delas enfermedades transmisibles en el hombre. 15 th ed.USA: Informe Oficial de la Asociación Estadounidense dela Salud Pública. Organización Panamericana de la Salud;1992.p. 520-523.

  6. Jenum PA, Kapperud G, Stray-Pedersen B, Melby KK,Eskild A, Eng J. Prevalence of Toxoplasma gondii specificimmunoglobulin G antibodies among pregnant women inNorway. Epidemiol Infect 1998; 120: 87-92.

  7. Dubey JP. Isolation of Toxoplasma gondii from naturallyinfected beef cow. J Parasitol 1992; 78 (1): 151-153.

  8. Dorny P. Prevalence of Toxoplasma gondii antibodies ingoats in Sri Lanka. Ann Trop Med Parasitol 1992; 86 (1):83-85.

  9. Lebech M, Larsen SO, Petersen E. Prevalence, incidenceand geographical distribution of Toxoplasma gondiiantibodies in pregnant women in Denmark. Scand J Dis1993; 25: 751-753.

  10. Baril L, Ancelle T, Goulet V, Thulliez P, Tirard-Fleury V,Carme B. Risk factors for toxoplasma infection inpegnancy: A case control study in France. Scand J InfectDis 1999; 31(3): 305-309.

  11. Pelloux H, Fricker-Hidalgo H, Brochier G, Goullier-FleuretA, Ambroise-Thomas P. Intravenous immunoglobulintherapy: Confounding effects on serological screeningfor toxoplasmosis during pregnancy. J Clin Microbiol 1999;37 (10): 3423-3424.

  12. Markell EK, Voge M, John DT. Otros protozoos de lasangre y los tejidos. En: Parasitología médica. 6a ed. Ma-drid: Interamericana; 1990.p. 104-151.

  13. Robert-Gangneux F, Commere V, Tourte-Schaefer C,Dupouy-Camet J. Performance of a Western blot assay tocompare mother and newborn anti-Toxoplasma antibodiesfor the early neonatal diagnosis of congenital toxo-plasmosis. Eur J Clin Microbiol Infect Dis 1999; 18 (9):648-654.

  14. Evengard B, Lilja G, Capraru T, Malm G, Kussofsky E,Oman H, et al. A retrospective study of seroconversionagainst Toxoplasma gondii during 3,000 pregnancies inStockholm. Scand J Infect Dis 1999; 31 (2): 127-129.

  15. Acha PN, Szyfres B. Toxoplasmosis. En: Zoonosis y enfer-medades transmisibles comunes al hombre y los animales.2da ed. Washington DC: Organización Panamericana dela Salud; 1989.p. 646-658.

  16. Jenum PA, Stray-Pedersen B, Melby KK, Kapperud G,Whitelaw A, Eskild A, et al. Incidence of Toxoplasmagondii infection in 35 940 pregnant women in Norwayand pregnancy outcome for infected women. J ClinMicrobiol 1998; 36(10): 2900-2906.

  17. Dunn D, Wallon M, Peyron F, Petersen E, Peckhman C,Gilbert R. Mother to child transmission of toxoplasmosis:risk estimates for clinical counselling. Lancet 1999; 353(9167): 1829-1833.

  18. Remington JS, Desmonts G. Toxoplasmosis. En: Infectiousdiseases of the fetus and newborn infants. 2nd ed.Philadelphia: J.S. Remington and J.O. Klein, eds. W.B.Saunders Company; 1990.p. 89-105.

  19. Allain JP, Palmer CR, Pearson G. Epidemiological studyof latent and recent infection by Toxoplasma gondii inpregnant women from a regional population in the U.K. JInfect 1998; 36: 189-196.

  20. Gire C, Nicaise C, Minodier P, Palix C, Boubli L, Garnier JM.Congenital toxoplasmosis with brain lesions despite antenataltreatment. Presse Medicale 1999; 28 (13): 686-688.

  21. Acosta C, Pérez X, García R. Presencia de anticuerpos IgGanti-Toxoplasma gondii en embarazadas residentes en Ciu-dad de la Habana. Rev Biomed 2001; 12: 250-254.

  22. Blanco R, Malberty A, López R. Estudio de la presencia deanticuerpos contra Toxoplasma gondii en sueros de ma-dres y recién nacidos en el momento del parto. Congreso50. Aniversario del Instituto de Medicina Tropical PedroKourí 1988; Resumen T-319: 137.

  23. González T, Bacallao J, García C, Molina JR. Prevalenciade anticuerpos anti-Toxoplasma gondii en una poblaciónde mujeres embarazadas en Cuba. Gac Méd Méx 1990;131 (5-6): 499-503.

  24. López R, Pérez X, Guerra E, Herrera R, Acosta C. Toxoplas-mosis entre mujeres embarazadas en Ciudad de laHabana. Rev Biomed 1993; 13 (4): 173-178.

  25. Jenum PA, Stray-Pedersen B. Development of specificimmunoglobulins G, M and A following primaryToxoplasma gondii infection in pregnant women. J ClinMicrobiol 1998; 36(10): 2907-2913.

  26. Thulliez Ph, Hohlfeld P, Dalfos F, Costa JM, Forestier F,Sole Y, et al. Nouvelle approche du diagnostic prénatal dela toxoplasmose congénitale. Journal de Pédiatrie et dePuériculture 1993; 6: 341-346.

  27. Kasper LH. Toxoplasma infection. In: Harrinson’sPrinciples of Internal Medicine-14th ed. CD-ROM 1998.

  28. Bahia-Oliveira LMG, Jones IL, Azevedo-Silva J, Alves CCF,Oréfice F, Addiss DG. Highly endemic, waterbornetoxoplasmosis in north Rio de Janeiro state, Brazil. EmergInfect Dis [serial online] 2003 Jan [date cited]; 8.

  29. Sigarroa A. Biometría y Diseño Experimental. 1ra ed. Cuba:Ed. Pueblo y Educación; 1985

  30. Sigarroa A. Manual de Clases Prácticas de Biometría yDiseño Experimental. 1ra ed. Cuba: Ed. Pueblo y Educa-ción; 1987.

  31. Fernández JL. Screening Technology Development-TheCuban Experience. 8th International Symposium onNeonatal Screening and Inaural Meeting of the Interna-tional Society for Neonatal Sreening. Sidney, Australia:Abstracts Book; 1991.

  32. Chatterton JM. Pregnancy. In: Human Toxoplasmosis. eds.Oxford Medical Publications; 1992.p.144-183.

  33. Ho-Yen D, Chatterton JW. Congenital toxoplasmosis whyand how to screen. Rev Med Microbiol 1990; 1: 229-235.

  34. Logar J, Novak-Antolic Z, Zore A, Cerar V, Likar M.Incidence of the congenital toxoplasmosis in the Republicof Slovenia. Scand J Infect Dis 1992; 24: 105-108.

  35. Remington JS, McLeod R, Desmonts G. Toxoplasmosis.In: Infectious diseases of the fetus and newborn infants.2nd ed. USA: J.S. Remington and J.O. Klein, eds. W.B.Saunders Company; 1995.p. 140-267.

  36. Martínez R, Machín R, Suárez M, Fachado A. Aspectosseroepidemiológicos de la toxoplasmosis en dos munici-pios de la provincia de Ciego de Avila. Rev Cub Med Trop1989; 41 (2): 214-225.

  37. López R, Pérez X, Collazo JE, Acosta C. Anticuerpos anti-Toxoplasma gondii en niños cubanos. Rev Biomed 1993;13(4): 183-6.38.Frenkel JK. Congenital toxoplasmosis. Preventionpallation. Am J Obst Gyn 1981; 141: 359.




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