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Coordinación General de Investigación de la Facultad de Salud Pública y Nutrición y la Dirección General de Sistemas e Informática de la Universidad Autónoma de Nuevo León

2021, Number 3

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Rev Salud Publica Nutr 2021; 20 (3)

SERUM IL-17, obesity, and metabolic risk in mexican young adults

Aradillas-García Celia;Monreal-Escalante Elizabeth;Vargas-Morales Juan Manuel;Alegría-Torres Jorge;Rosales-Mendoza Sergio;Terán-García Margarita; Portales-Pérez Diana P

Language: Spanish
References: 36
Page: 1-7
PDF size: 282.83 Kb.


ABSTRACT

Introduction: Obesity and several inflammatory pathways contribute to the development of metabolic diseases. Some pro-inflammatory cytokines and other signal proteins produced in fat and liver appear to propagate inflammation systemically. IL-17 is a pro-inflammatory cytokine secreted by activated T-cells. Upon binding to its receptor, IL-17 activates a cascade of signals that include MAPK, NF-kB and other pro- inflammatory cytokines. Objective: Determine if the IL-17 levels are associated with obesity and its metabolic comorbidities in young adults. Method: Cross-sectional study in the UP AMIGOS 2009 cohort. Anthropometric measurement and blood samples were collected. Fasting glucose, insulin, and serum lipid profile was measured by conventional methods. Serum IL-17 was determined by ELISA assay in 102 individuals with obesity and overweight also in 306 lean students (aged 18 to 26 years old. Results: Higher levels of IL-17 were found in the group with obesity (34.99 pg/mL) when compared to lean subjects (26.57 pg/mL). In addition, a positive correlation between serum IL-17 and body mass index and waist circumference in the group with obesity were detected. Conclusions: Increased IL-17 levels in young individuals with obesity and overweight are associated with risk factors for developing chronic metabolic diseases.


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