2021, Number 2
<< Back Next >>
Acta Med 2021; 19 (2)
Acute kidney injury in patients with COVID-19 in the Intensive Care Unit of the Hospital Ángeles Pedregal
Martínez MI, Ochoa SH, Enríquez BA, Teniza FE, Vargas GK, Padilla PFJ, Díaz GEJ, Esponda PJG
Language: Spanish
References: 26
Page: 229-235
PDF size: 173.45 Kb.
ABSTRACT
In December 2019 in China, the presence of SARS-CoV-2 was reported, which the WHO called COVID-19, its main manifestation is respiratory. It has been reported that up to 25% of patients with SARS-CoV-2 develop acute kidney injury and their mortality is 91.7%.
Objective: Describe the characteristics of patients infected by COVID-19 and who developed kidney damage.
Material and methods: Patients admitted to the Intensive Care Unit at
Hospital Ángeles Pedregal, who had a positive test for SARS-CoV-2, were studied. Renal function values were followed according to the laboratory values of our unit.
Results: Our study consists of 22 cases, of which 10 (45%) did not present acute kidney injury, 12 (55%) with acute kidney injury, with the following distribution: four (18%) AKI I, five (23%) AKI II and three (14%) AKI III.
Conclusions: The incidence of AKI was higher than that reported in the literature, with 55% of the cases, requiring hemodialysis in 33% of the cases. Mortality was 15.1% according to SAPS-3, which was notably lower than that reported in the literature.
REFERENCES
Zhu N, Zhang D, Wang W, Li X, Yang B, Song J et al. A Novel Coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020; 382 (8): 727-733.
Lu R, Zhao X, Li J, Niu P, Yang B, Wu H et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020; 395 (10224): 565-574.
https://covid19.cdmx.gob.mx/comunicacion/nota/reporte-21-de-julio
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395 (10223): 497-506.
Chu KH, Tsang WK, Tang CS, Lam MF, Lai FM, To KF et al. Acute renal impairment in coronavirus-associated severe acute respiratory syndrome. Kidney Int. 2005; 67 (2): 698-705.
Shimabukuro-Vornhagen A, Godel P, Subklewe M, Stemmler HJ, Schlober HA, Schlaak M et al. Cytokine release syndrome. J Immunother Cancer. 2018; 6 (1): 56.
Tisoncik JR, Korth MJ, Simmons CP, Farrar J, Martin TR, Katze MG. Into the eye of the cytokine storm. Microbiol Mol Biol Rev. 2012; 76 (1): 16-32.
Kellum JA, Lameire N; KDIGO AKI Guideline Work Group. Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1). Crit Care. 2013; 17 (1): 204.
Cheng Y, Luo R, Wang K, Zhang M, Wang Z, Dong L et al. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int. 2020; 97 (5): 829-838.
Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with covid-19 in the New York City area. JAMA. 2020; 323 (20): 2052-2059.
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020; 395 (10229): 1054-1062. Erratum in: Lancet. 2020; 395 (10229):1038.
Husain-Syed F, Ricci Z, Brodie D, Vincent JL, Ranieri VM, Slutsky AS et al. Extracorporeal organ support (ECOS) in critical illness and acute kidney injury: from native to artificial organ crosstalk. Intensive Care Med. 2018; 44 (9): 1447-1459.
Ronco C, Bellomo R, Kellum JA. Acute kidney injury. Lancet. 2019; 394 (10212): 1949-1964.
Brower RG, Matthay MA, Morris A, Schoenfeld D, Thompson BT, Wheeler A. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000; 342 (18): 1301-1308.
Annat G, Viale JP, Bui Xuan B, Hadj Aissa O, Benzoni D, Vincent M et al. Effect of PEEP ventilation on renal function, plasma renin, aldosterone, neurophysins and urinary ADH, and prostaglandins. Anesthesiology. 1983; 58 (2): 136-141.
Andres-Hernando A, Dursun B, Altmann C, Ahuja C, He Z, Bhargava R et al. Cytokine production increases and cytokine clearance decreases in mice with bilateral nephrectomy. Nephrol Dial Transplant. 2012; 27 (12): 4339-4347.
Upadhyaya VD, Shariff MZ, Mathew RO, Hossain MA, Asif A, Vachharajani TJ. Management of acute kidney injury in the setting of acute respiratory distress syndrome: review focusing on ventilation and fluid management strategies. J Clin Med Res. 2020; 12 (1): 1-5.
McNicholas BA, Rezoagli E, Pham T, Madotto F, Guiard E, Fanelli V et al. Impact of early acute kidney injury on management and outcome in patients with acute respiratory distress syndrome: a secondary analysis of a multicenter observational study. Crit Care Med. 2019; 47 (9): 1216-1225.
Matthay MA, Aldrich JM, Gotts JE. Treatment for severe acute respiratory distress syndrome from COVID-19. Lancet Respir Med. 2020; 8 (5): 433-434.
Abu Alfeilat M, Slotkil I, Shavit L. Single emergency room measurement of neutrophil/lymphocyte ratio for early detection of acute kidney injury (AKI). Intern Emerg Med. 2018; 13 (5): 717-725.
Guthrie GJ, Charles KA, Roxburgh CS, Horgan PG, McMillan DC, Clarke SJ. The systemic inflammation-based neutrophil-lymphocyte ratio: experience in patients with cancer. Crit Rev Oncol Hematol. 2013; 88 (1): 218-230.
Bazick HS, Chang D, Mahadevappa K, Gibbons FK, Christopher KB. Red cell distribution width and all-cause mortality in critically ill patients. Crit Care Med. 2011; 39 (8): 1913-1921.
Hunziker S, Celi LA, Lee J, Howell MD. Red cell distribution width improves the simplified acute physiology score for risk prediction in unselected critically ill patients. Crit Care. 2012; 16 (3): R89.
Leekha S, Standiford HC. Empiric antimicrobial therapy for Gram-negative sepsis: back to the future. Crit Care Med. 2011; 39 (8): 1995-1996.
Balta S, Demirkol S, Akgul EO. Red blood cell distribution width is predictive of mortality in trauma patients. J Trauma Acute Care Surg. 2013; 75 (2): 345-346.
Ju XF, Wang F, Wang L, Wu X, Jiang TT, You DL et al. Dynamic change of red cell distribution width levels in prediction of hospital mortality in Chinese elderly patients with septic shock. Chin Med J (Engl). 2017; 130 (10): 1189-1195.