Villanueva P, Díaz P, Guido M, Rangel A, Sotelo R, García-Carrancá A

Language: Spanish
References: 24
Page: 94-102
PDF size: 218.33 Kb.

ABSTRACT

Almost 70 types of Human Papilloma virus (HPV) are associated with lesions of the anogenital tract. High-risk HPV types (such as HPV16, 18, 30, 31, and 33) are frequently found associated with anal squamous intraepithelial lesions. It has been shown that HIV-positive men who have sex with men are in higher risk of developing precancerous anal lesions. This increased risk is related to HPV infection and to the immunosupression associated with HIV.
The present work is a cross-sectional study with 31 HIVpositive men who have sex with men (MSM) to determine the prevalence of HPV in the anal canal. HPV DNA was detected using the Hybrid Capture II assay. Anal infection of HPV was detected in 74.2% of the subjects. Infection with multiple types (positive to both assays: low and high-oncogenic risk types) was found in 58%. This study emphasizes the need for HPV screening in HIVpositive MSM due to their high risk for HPV anal infection and HPV-associated anal disease.

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