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Anales de Otorrinolaringología Mexicana

2021, Number 2

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Otorrinolaringología 2021; 66 (2)

Efficacy and safety in the use of platelet rich plasma as an adjuvant in cartilage graft timpanoplasty vs cartilage graft-only tympanoplasty

Reyes-Mercado EE, Rico-Maldonado MÁ, Mojica-Arce SA, Hernández-González MA

Language: Spanish
References: 18
Page: 110-118
PDF size: 251.87 Kb.


ABSTRACT

Objective: To determine the efficacy and safety of platelet rich plasma (PRP) as an adjuvant for tympanoplasty for perforations of the tympanic membrane with butterfly cartilage graft vs tympanoplasty with cartilage graft only.
Materials and Methods: A randomized, controlled, clinical trial, including patients with tympanic membrane perforation, divided into two groups. Group 1 underwent endomeatal tympanoplasty with butterfly cartilage graft without PRP and group 2 underwent same tympanoplasty technique and PRP was added. The size of the tympanic perforation was assessed preoperatively, and the follow up included persistence for 8 weeks postoperatively in both groups.
Results: The index of healing of the tympanic membrane was higher with the tympanoplasty that used the PRP compared to the control group, with statistical significance (p = 0.026) at the end of the follow-up (8 weeks). The patients in the experimental group had an evolution period (chronicity) of 18-24 months since their diagnosis, with significant statistical difference (p = 0.039).
Conclusions: The healing of the tympanic membrane is superior with the use of PRP as adjuvant in endomeatal tympanoplasty with butterfly cartilage graft despite the time of chronicity; during the follow-up, no patient in the study presented with adverse effects derived from the procedure or to the application of PRP.


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