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Medicina & Laboratorio

2017, Número 07-08

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Medicina & Laboratorio 2017; 23 (07-08)


Utilidad clínica de la medición de la hormona antimülleriana en niños

Lasprilla-Tovar JD, Henao-Ochoa C, Alfaro-Velásquez JM, Campuzano-Maya G

Idioma: Español
Referencias bibliográficas: 103
Paginas: 311-330
Archivo PDF: 634.08 Kb.


RESUMEN

la hormona antimülleriana, inicialmente denominada sustancia inhibitoria mülleriana, es una glicoproteína homodimérica de 12,5 kDa, que pertenece a la familia del factor de crecimiento transformante beta (TGF-β) y desempeña un papel crucial en la diferenciación sexual masculina al favorecer la regresión de los conductos de Müller. Dado que su producción en el varón es principalmente por las células de Sertoli inmaduras, en las últimas décadas ha crecido su utilidad más allá de la evaluación de la función ovárica y tratamientos de fertilidad en las mujeres, lo que ha permitido evaluar en el varón la función testicular y los estados de hipogonadismo, trastornos de la diferenciación sexual, pubertad patológica, criptorquidia, entre otras condiciones clínicas revisadas en este manuscrito. Además, esta revisión describe el rol fisiológico de la hormona antimülleriana en los testículos prepuberales y las pruebas de laboratorio disponibles para su medición.


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