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Colegio de Medicina Interna de México.

2021, Número 1

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Med Int Mex 2021; 37 (1)


Mirtazapina en trastorno depresivo mayor: revisión crítica de la evidencia científica

Ramírez-Bermúdez J, Aldrete-Velasco J, Enríquez-Ramos MS, Camacho-Silva B

Idioma: Español
Referencias bibliográficas: 64
Paginas: 62-77
Archivo PDF: 438.19 Kb.


RESUMEN

El trastorno depresivo mayor es una afección caracterizada por un patrón clínico en el que los síntomas emocionales cardinales (el ánimo depresivo y la anhedonia) se acompañan de alteraciones cognitivas y somáticas que producen un marcado deterioro funcional, así como un malestar subjetivo clínicamente significativo. En este artículo, se revisa la neurobiología de este trastorno y de los efectos terapéuticos de mirtazapina, un antidepresivo que actúa simultáneamente en los sistemas noradrenérgico y serotoninérgico. Por su mecanismo de acción, la mirtazapina potencia la liberación de estos neurotransmisores en el sistema nervioso central. En la actualidad, los metanálisis muestran que mirtazapina es uno de los tratamientos más eficaces en pacientes con trastorno depresivo mayor. Además, se ha estudiado la eficacia y la seguridad de mirtazapina en poblaciones especiales, incluyendo personas de la tercera edad y pacientes con comorbilidades.


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