2019, Número 2
El bajo peso al nacer como una lesión ateroesclerótica temprana
Fundora ÁV, Zayas SEM
Idioma: Español
Referencias bibliográficas: 163
Paginas: 426-449
Archivo PDF: 542.17 Kb.
RESUMEN
El bajo peso al nacer (BPN) constituye un problema global de salud que suele presentarse
entre el 10 – 15% de los nacimientos vivos, y que impacta particularmente a los países de
bajos y medianos ingresos. El BPN puede afectar la supervivencia del niño y su posterior
crecimiento y desarrollo, en especial el neurodesarrollo. El BPN es tenido hoy también como
una señal temprana de ateroesclerosis ante reportes crecientes de que los niños con bajo peso
suelen exhibir mayores tasas de las distintas manifestaciones de la Gran Crisis
Ateroesclerótica (GCA) en la adultez, entre ellas la coronarioesclerosis y la enfermedad
cerebrovascular. Asimismo, los niños con BPN podrían tener un riesgo mayor de exceso de
peso y obesidad global y abdominal en edades posteriores. Igualmente, los niños nacidos con
bajo peso podrían mostrar una mayor prevalencia de hipertensión arterial (HTA) y Diabetes
mellitus tipo 2 (DMT2): eventos éstos agravantes de la ateroesclerosis. El seguimiento a
largo plazo de los niños nacidos con bajo peso implicaría la identificación temprana y
oportuna de alteraciones bioquímicas anticipatorias del Síndrome metabólico (SM) tales
como estados alterados de la utilización periférica de los carbohidratos, dislipidemias e
hiperuricemia. El seguimiento a largo plazo de estos niños también implicaría la detección de
azotemia y albuminuria como indicadores de daño renal. El reconocimiento del BPN como
una señal temprana de la ateroesclerosis haría posible entonces la intervención farmacológica
y dietética adecuada, y con ello, la disminución del riesgo de eventos arteriooclusivos agudos
en la adultez, todo lo cual coadyuvaría a una expectativa de vida más prolongada y una
calidad de vida superior.
Fundora Álvarez V, Zayas Somoza EM. El bajo peso al nacer
como una lesión ateroesclerótica temprana. RCAN Rev Cubana Aliment Nutr
2019;29(2):426-449. RNPS: 2221. ISSN: 1561-2929.
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