Ávila TA, Bassols ÁC, Elizalde GJJ

Idioma: Español
Referencias bibliográficas: 35
Paginas: 204-208
Archivo PDF: 249.11 Kb.

RESUMEN

El análisis histopatológico constituye el estudio rey de todos las pruebas diagnósticas en medicina. Sin embargo, las características particulares de la pandemia por COVID-19 han impuesto serias restricciones a estos análisis, por lo que la información específica al respecto es limitada. En el presente trabajo, se hace una reflexión sobre estos aspectos y se presentan algunos de los hallazgos más sobresalientes reportados en la literatura, que no se limitan al daño alveolar difuso, sino que abarcan algunas otras entidades complejas, las cuales deben analizarse con cuidado por tener importantes implicaciones terapéuticas, tanto en la estrategia de asistencia mecánica ventilatoria como en la farmacológica.

REFERENCIAS (EN ESTE ARTÍCULO)

1. Bogaert D, Dockrell DH. 100 years of influenza research seen through the lens of COVID-19. Mucosal Immunol. 2020;13:561-562. doi: org/10.1038/s41385-020-0291-9.

2. Pomara C, Volti G, Cappello F. COVID-19 deaths: are we sure it is pneumonia? Please, autopsy, autopsy, autopsy! J Clin Med. 2020;9(5):1259. doi: 10.3390/jcm9051259.

3. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. doi: 10. 1016/S0140-6736(20)30183-5.

4. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-1069. doi: 10.1001/jama.2020.1585.

5. Schaller T, Hirschbühl K, Burkhardt K, Braun G, Trepel M, Claus R, et al. Post mortem examination of patients with COVID-19. JAMA. 2020;323(24):2518-2520. In https: jamanetwork.com/by a Mexico accese by JAMA/05/23/2020.

6. Varga Z, Flammer, Steiger A, Haberecker M, Andermatt R, et al. Endothelial cell infection and endothelitis in COVID-19. Lancet. 2020;295:1417-1418. https://doi.org/10.1016/ S0140-6736(20)30917-X.

7. Hanley B, Lucas S, Youd E, Swift B, Osborn M. Autopsy in suspected COVID-19 cases. J Clin Pathol. 2020;73:239-242. doi: 10.1136/jclinpath-2020-206522239.

8. Fraire AE, Libraty D, Dizon F, Olveda RM, Woda BA. Severe acute respiratory syndrome. In: Cagle PT, Allen TC. Color atlas and text of pulmonary pathology. 2a. ed. Philadelphia: Lippincott, Williams & Wilkins; 2008, pp. 417-418.

9. Wan Y, Shang J, Graham R, Baric RS, Li F. Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus. J Virol. 2020;94(7):e00127-20. doi: 10.1128/JVI.00127-20.

10. Yan T, Xioa R, Lin G. Angiotensin-converting enzyme 2 in severe acute respiratory syndrome coronavirus and SARS-CoV-2: a double-edged sword? The FASEB Journal. 2020;34:6017-6026.

11. Elizalde GJJ. COVID-19 physiopathology. Med Crit. 2020; 33(3):

12. Roy SF, Cecchini MJ. Implementing a structured digital-based online pathology curriculum for trainees at the time of COVID-19. J Clin Pathol. 2020;73-444. doi: 10.1136/jclinpath-2020-206682.

13. Barton M, Duval E, Stroberg E, Ghosh S, Mukhopadhyay S. COVID-19 Autopsies, Oklahoma, USA. In Am J Clin Pathol. 2020;153(6):725-733. doi: 10.1093/AJCP/AQAA062.

14. Copin MC, Parmentier E, Duburcq T, Poissy J, Mathieu D, Lille COVID-19 ICU and anatomopathology group. Time to consider histologic pattern of lung injury to treat critically ill patients with COVID-19 infection. Int Care Med. 2020. doi: orh/10-1007/s00134-020-06057-8.

15. Gattinoni L, Chuimello D, Caironi O, Busana M, Romitti F, Brazzi L, et al. COVID-19 pneumonia: different respiratory treatment for different phenotypes? Int Care Med. 2020;46:1099-1102. doi: org/10.1007/s00134-020-06033-2.

16. Tian S, Hu W, NiuL, Xu H, Xiao SY. Pulmonary pathology of early-phase 2019 novel Coronavirus (COVID-19) pneumonia in two patients with lung cancer. J of Thoracic Oncology. 2020;15(5):700-704.

17. Xu Z, Wang Y, Zhang J, Huang L, Zhang C, Liu S, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020;8:420-422. doi: org/10.1016/S2213-2600(20)30076-X.

18. Li H, Liu L, Zhang D, Xu J, Dai H, Tang N, et al. SARS-CoV2 and viral sepsis: observations and hypotheses. The Lancet. 2020;395:1517. doi: org/10.1016/ S0140-6736(20)30920-X.

19. Lacy J, Brooks E, Akers J, Armstrong D, Decker L, et al. COVID-19; post-mortem diagnostic and Biosafety considerations. Am J Forensic Med Pathol. 2020. doi: 10.1097/PAF.0000000000000567.

20. Chen L, Li X, Chen M, Feng Y, Xiong Ch. The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2. Cardiovasc Res. 2020;116(6):1097-1100. doi: 10.1093/cvr/cvaa078.

21. Fox SE, Akmatbekov A, Harbert JL, Li G, Brrown JQ, Vander Heide RS. Pulmonary and cardiac pathology in COVID-19: The first autopsy series from New Orleans. MedRxiv. doi: org/10.1101/2020.04.06.20050575.

22. Ackermann M, Verleden S, Kuehnel M, Haverich A, Welte T, Laenger F, et al. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in COVID-19. N Engl J Med. 2020;383:120-218. doi: 10.1056/NEJMoa2015432.

23. Madjid M, Safavi-Naeini P, Solomon SD, Vardeny O. Potential effects of coronaviruses on the cardiovascular system a review. JAMA Cardiol. 2020. doi: 10.1001/jamacardio.2020.1286.

24. Wichmann D, Sperhake JP, Lütgehetmann M, Steurer S, Edler C, Heinemann A, et al. Autopsy findings and venous thromboembolism in patients with COVID-19: a prospective cohort study. Ann Int Med. 2020; doi: 10.7326/M20-2003.

25. Tomashefski JF Jr, Davies P, Boggis C, Greene R, Zapol WM, Reid LM, et al. The pulmonary vascular lesions of the ARDS. Am J Pathol. 1983;112:112-126.

26. McGonagle D, O’Donnell J, Sharif K, Emery P, Bridgewood Ch. Why the immune mechanisms of Pulmonary Intravascular Coagulopathy in COVID-19 pneumonia are distinct from macrophage activation syndrome with disseminated intravascular coagulation. The Lancet. 2020;2(7):E437-E445. Disponible en: www.reserchgate.net/publication/doi: 10.13140/RG.2.2.19782.83521

27. Buja M, Wolf D, Zhao B, Akkanti B, McDonald M, Lelenwa L, et al. Emerging spectrum of cardiopulmonary pathology of the coronavirus disease 2019 (COVID-19): report of three autopsies from Houston, Texas and review of autopsy findings from other united states cities. Cardiovasc Pathol. 2020;48:107233. doi: org/10.1016/j.carpath.2020.107233.

28. Carsana L, Sonzoguia A, Nasr A, Rossi RS, Zerbi P, et al. Pulmonary post-mortem findings in the large series of COVID 19 cases form North Italy: a two-centre descriptive study. medRvix. 2020. doi: org/10.1101/2020.04.19.20054262.

29. Merad M, Martin J. Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages. Nat Rev Immunol. 2020;20:355-362. doi: org/10.1038/s41577-020-0331-4.

30. Barbarareschi M, Facchetti F, Fraggetta F, et al. What are the priorities of pathologists’ activities during COVID-19 emergency? Pathologica Epub. 2020;112(2). https://doi.org/10.32074/1591-951X-15-20.

31. Parraguirre MS, De Anda MGJ, Mantilla A, Uribe NO. Guías de manejo en el laboratorio de Anatomía Patológica de cadáveres y material biológico de pacientes con diagnóstico o sospecha de COVID-19. Patología Rev Latinoam. 2020;58:1-9. doi: org/10.24245/patrl.v58id.4253.

32. Rao CH. Medical certification of cause of death for COVID-19. In www.who.int/bulletin/volumes/98/5/20-257600.

33. COVID-19 dashboard by the Center for system science and engineering (CSSE) at John Hopkins University (JHU) /25/05/2020.

34. Fauci A, Lane HC, Redfield R. On progress made during the past four decades of the HIV/AIDS pandemic and ongoing efforts to end this threat. Supplement to the N Eng J Med 2020; 383:1-4

35. The Cell Editorial Team. COVID-19: navigating uncertainties together. Cell. 2020;181(2):209-210. doi: org/10.1016/j.cell.2020.03.04.