Campuzano-Maya G

Idioma: Español
Referencias bibliográficas: 23
Paginas: 509-512
Archivo PDF: 151.72 Kb.

FRAGMENTO

La Organización Mundial de la Salud (OMS) y la Sociedad Internacional de Trombosis y Hemostasia (SITH), en 1995, definieron la trombofilia como una tendencia anormal a desarrollar trombosis, que se caracteriza por manifestaciones como a edad de inicio temprana, episodios recurrentes, antecedentes familiares notables, localizaciones poco habituales, migratorias o generalizadas y una gravedad desproporcionada respecto a todo estímulo identificado; también hace referencia a los estados de hipercoagulabilidad que son el resultado final de enfermedades, trastornos o alteraciones que potencian la propensión del individuo a que se le formen coágulos de sangre en los sistemas venoso, arterial o de la microcirculación. Las trombofilias hereditarias son estados relativamente raros pero en la medida en que se identifiquen oportunamente permiten hacer manejo preventivo primario.

REFERENCIAS (EN ESTE ARTÍCULO)

1. Lane DA, Mannucci PM, Bauer KA, Bertina RM, Bochkov NP, Boulyjenkov V, et al. Inherited thrombophilia: Part 1. Thromb Haemost 1996;76:651-662.

2. Lane DA, Mannucci PM, Bauer KA, Bertina RM, Bochkov NP, Boulyjenkov V, et al. Inherited thrombophilia: Part 2. Thromb Haemost 1996;76:824-834.

3. Egeberg O. Inherited Antithrombin Deficiency Causing Thrombophilia. Thromb Diath Haemorrh 1965;13:516-530.

4. Griffin JH, Evatt B, Zimmerman TS, Kleiss AJ, Wideman C. Deficiency of protein C in congenital thrombotic disease. J Clin Invest 1981;68:1370- 1373.

5. Holiday PL, Mammen E, Gilroy J. Sticky platelet syndrome and cerebral infarction in young adults. Presented at the Ninth International Joint Conference on Stroke and Cerebral Circulation; 1983 (abstract). Phoenix, Arizona. . Circulation (suppl) 1983

6. Comp PC. The activation and effects of protein C, an antithrombotic protein, in vivo. Surv Synth Pathol Res 1984;3:31-37.

7. Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994;369:64-67.

8. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3’-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996;88:3698-3703.

9. Baglin T, Gray E, Greaves M, Hunt BJ, Keeling D, Machin S, et al. Clinical guidelines for testing for heritable thrombophilia. Br J Haematol 2010;149:209-220.

10. Moll S. Who should be tested for thrombophilia? Genet Med 2011;13:19-20.

11. Lippi G. Thrombophilia testing. Useful or hype? Clin Chem Lab Med 2014;52:467-469.

12. Graham N, Rashiq H, Hunt BJ. Testing for thrombophilia: clinical update. Br J Gen Pract 2014;64:e120-122.

13. Cohoon KP, Heit JA. Inherited and secondary thrombophilia. Circulation 2014;129:254-257.

14. Graffigna G, Leone D, Vegni E. “Am I carrier?” The patient’s lived experience of thrombophilia genetic screening and its outcome. Health Psychol Behav Med 2014;2:696-712.

15. Yang JY, Chan AK. Pediatric thrombophilia. Pediatr Clin North Am 2013;60:1443-1462.

16. Nicolaides A, Hull RD, Fareed J, Cardiovascular Disease E, Research T, European Venous F, et al. Thrombophilia. Clin Appl Thromb Hemost 2013;19:177-187.

17. Ruíz-Argüelles GJ, Ruíz-Delgado GJ. How we study and treat patients with suspected thrombophilia. Medicina Universitaria 2014;16:143-145.

18. Piazza G. Thrombophilia testing, recurrent thrombosis, and women’s health. Circulation 2014;130:283-287.

19. Piazza G. Cardiology patient page. Thrombophilia and hypercoagulability. Circulation 2014;130:e9-10.

20. Hornsby LB, Armstrong EM, Bellone JM, Treadway S, Phillippe HM. Thrombophilia Screening. J Pharm Pract 2014;27:253-259.

21. Franchini M. The utility of thrombophilia testing. Clin Chem Lab Med 2014;52:495-497.

22. Favaloro EJ. The futility of thrombophilia testing. Clin Chem Lab Med 2014;52:499-503.

23. Weingarz L, Schwonberg J, Schindewolf M, Hecking C, Wolf Z, Erbe M, et al. Prevalence of thrombophilia according to age at the first manifestation of venous thromboembolism: results from the MAISTHRO registry. Br J Haematol 2013;163:655-665.