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Instituto Nacional de Salud Pública

2020, Número 3

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salud publica mex 2020; 62 (3)


Exposición a arsénico en mujeres del norte de México

Gamboa-Loira B, Cebrián ME, López-Carrillo L

Idioma: Ingles.
Referencias bibliográficas: 34
Paginas: 262-269
Archivo PDF: 307.46 Kb.


RESUMEN

Objetivo. Describir las variaciones interindividuales del metabolismo y las características sociodemográficas asociadas con el arsénico urinario, así como estimar su contaminación en el agua. Material y métodos. Se entrevistó a 1 028 mujeres del norte de México; por cromatografía de líquidos se midieron los metabolitos urinarios de arsénico y, a partir de ellos, se estimó la concentración en agua. Resultados. Las mujeres tuvieron 20-88 años. El arsénico urinario varió de p10=3.41 a p90=56.93 µg/L; 74% de las mujeres tuvieron niveles ›6.4 µg/L. El arsénico en agua varió de p10=3.04 a p90=202.12 µg/L; 65% de las mujeres tenían concentraciones ›10 µg/L, y 41%, ›25 µg/L. Se observaron amplias variaciones en el metabolismo del arsénico. El arsénico urinario se asoció negativamente con la edad y escolaridad, y positivamente con el estado de residencia. Conclusión. La exposición a arsénico es un problema ambiental en México. Las variaciones individuales en su metabolismo son un desafío para diseñar programas de prevención y control.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Bundschuh J, Litter MI, Parvez F, Román-Ross G, Nicolli HB, Jean JS, et al. One century of arsenic exposure in Latin America: A review of history and occurrence from 14 countries. Sci Total Environ. 2012;429:2-35. https://doi.org/10.1016/j.scitotenv.2011.06.024

  2. Mukherjee A, Sengupta MK, Hossain MA, Ahamed S, Das B, Nayak B, et al. Arsenic contamination in groundwater: a global perspective with emphasis on the Asian scenario. J Health Popul Nutr. 2006:24(2):142-63. https://doi.org/10.3329/jhpn.v24i2.727

  3. World Health Organization. Exposure to Arsenic: A Major Public Health Concern [Internet]. Geneva: 2010 [cited 2018 Jun 25]. Available from: http://www.who.int/ipcs/features/arsenic.pdf?ua=1

  4. Hays SM, Aylward LL, Gagné M, Nong A, Krishnan K. Biomonitoring Equivalents for inorganic arsenic. Regul Toxicol Pharmacol. 2010;58(1):1-9. https://doi.org/10.1016/j.yrtph.2010.06.002

  5. Smedley PL, Kinniburgh DG. A review of the source, behaviour and distribution of arsenic in natural waters. Appl Geochemistry. 2002;17:517- 68. https://doi.org/10.1016/S0883-2927(02)00018-5

  6. Secretaría de Salud. Norma Oficial Mexicana NOM-127- SSA1-1994-2000 Salud ambiental, Agua para uso y consumo humano. Límites permisibles de calidad y tratamientos a que debe someterse el agua para su potabilización (Modificación del año 2000). México: Secretaría de Salud, 2000 [cited 2018 Jun 25]. Available from: http://www.salud.gob.mx/ unidades/cdi/nom/m127ssa14.html

  7. Agency for Toxic Substances and Disease Registry. Toxicological profile for arsenic. Atlanta: Department of Health and Human Services, Public Health Service, 2007 [cited 2018 Jun 25]. Available from: https://www. atsdr.cdc.gov/toxprofiles/tp2.pdf

  8. Shen H, Niu Q, Xu M, Rui D, Xu S, Feng G, et al. Factors affecting arsenic methylation in arsenic-exposed humans: A systematic review and meta-analysis. Int J Environ Res Public Health. 2016;13(2):205. https://doi. org/10.3390/ijerph13020205

  9. Tseng C-H. Arsenic Methylation, Urinary Arsenic Metabolites and Human Diseases: Current Perspective. J Environ Sci Heal Part C. 2007;25(1):1-22. https://doi.org/10.1080/10590500701201695

  10. Kuo C-C, Moon KA, Wang S-L, Silbergeld E, Navas-Acien A. The Association of Arsenic Metabolism with Cancer, Cardiovascular Disease, and Diabetes: A Systematic Review of the Epidemiological Evidence. Environ Health Perspect. 2017;125(8):087001. https://doi.org/10.1289/EHP577

  11. Tseng CH. A review on environmental factors regulating arsenic methylation in humans. Toxicology and Applied Pharmacology. 2009;235(3):338-50. https://doi.org/10.1016/j.taap.2008.12.016

  12. Hernández A, Marcos R. Genetic variations associated with interindividual sensitivity in the response to arsenic exposure. Pharmacogenomics. 2008;9(8):1113-32. https://doi.org/10.2217/14622416.9.8.1113

  13. López-Carrillo L, Gamboa-Loira B, Becerra W, Hernández-Alcaraz C, Hernández-Ramírez RU, Gandolfi AJ, et al. Dietary micronutrient intake and its relationship with arsenic metabolism in Mexican women. Environ Res. 2016;151:445-50. https://doi.org/10.1016/j.envres.2016.08.015

  14. Quiller G, Mérida-Ortega Á, Rothenberg SJ, Cebrián ME, Gandolfi AJ, Franco-Marina F, et al. Dietary flavonoids improve urinary arsenic elimination among Mexican women. Nutr Res. 2018;55:65-71. https://doi. org/10.1016/j.nutres.2018.04.012

  15. Gamboa-Loira B, Hernández-Alcaraz C, Gandolfi AJ, Cebrián ME, Burguete-García A, García-Martínez A, et al. Arsenic methylation capacity in relation to nutrient intake and genetic polymorphisms in one-carbon metabolism. Environ Res. 2018;164:18-23. https://doi.org/10.1016/j. envres.2018.01.050

  16. López-Carrillo L, Hernández-Ramírez RU, Gandolfi AJ, Ornelas- Aguirre JM, Torres-Sánchez L, Cebrian ME. Arsenic methylation capacity is associated with breast cancer in northern Mexico. Toxicol Appl Pharmacol. 2014;280:53-9. https://doi.org/10.1016/j.taap.2014.07.013

  17. Gilbert-Diamond D, Cottingham KL, Gruber JF, Punshon T, Sayarath V, Gandolfi AJ, et al. Rice consumption contributes to arsenic exposure in US women. Proc Natl Acad Sci U S A. 2011;108(51):20656-60. https://doi. org/10.1073/pnas.1109127108

  18. Barr DB, Landsittel D, Nishioka M, Thomas K, Curwin B, Raymer J, et al. A survey of laboratory and statistical issues related to farmworker exposure studies. Environ Health Perspect. 2006;114(6):961-8. https://doi. org/10.1289/ehp.8528

  19. Calderon RL, Hudgens E, Le XC, Schreinemachers D, Thomas DJ. Excretion of arsenic in urine as a function of exposure to arsenic in drinking water. Environ Health Perspect. 1999;107(8):663-7. https://doi. org/10.1289/ehp.99107663

  20. Calderon RL, Hudgens EE, Carty C, He B, Le XC, Rogers J, et al. Biological and behavioral factors modify biomarkers of arsenic exposure in a U.S. population. Environ Res. 2013;126:134-44. https://doi.org/10.1016/j. envres.2013.04.004

  21. Roswall N, Hvidtfeldt U, Harrington J, Levine K, Sørensen M, Tjønneland A, et al. Predictors of Urinary Arsenic Levels among Postmenopausal Danish Women. Int J Environ Res Public Health. 2018;15(7):1340. https:// doi.org/10.3390/ijerph15071340

  22. Drewnowski A, Rehm CD, Constant F. Water and beverage consumption among adults in the United States: cross-sectional study using data from NHANES 2005-2010. BMC Public Health. 2013;13:1068. https://doi. org/10.1186/1471-2458-13-1068

  23. Martinez H. Ingesta de líquidos por adultos mexicanos; un estudio transversal. Nutr Hosp. 2014;29(5):1179-87. https://doi.org/10.3305/ nh.2014.29.5.7447

  24. Cutler DM, Lleras-Muney A, Vogl T. Socioeconomic Status and Health: Dimensions and Mechanisms. NBER Working Paper Series. Cambridge, MA: The National Bureau of Economic Research. 2008. Report No: 14333.

  25. Argos M, Parvez F, Chen Y, Hussain AZMI, Momotaj H, Howe GR, et al. Socioeconomic status and risk for arsenic-related skin lesions in Bangladesh. Am J Public Health. 2007;97(5):825-31. https://doi.org/10.2105/ AJPH.2005.078816

  26. Rosado JL, Ronquillo D, Kordas K, Rojas O, Alatorre J, Lopez P, et al. Arsenic exposure and cognitive performance in Mexican Schoolchildren. Environ Health Perspect. 2007;115(9):1371-5. https://doi.org/10.1289/ ehp.9961

  27. Barr DB, Wilder LC, Caudill SP, Gonzalez AJ, Needham LL, Pirkle JL. Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements. Environ Health Perspect. 2005;113(2):192-200. https://doi.org/10.1289/ehp.7337

  28. Basu A, Mitra S, Chung J, Guha-Mazumder DN, Ghosh N, Kalman D, et al. Creatinine, diet, micronutrients, and arsenic methylation in West Bengal, India. Environ Health Perspect. 2011;119(9):1308-13. https://doi. org/10.1289/ehp.1003393

  29. Nermell B, Lindberg A-L, Rahman M, Berglund M, Persson LA, El Arifeen S, et al. Urinary arsenic concentration adjustment factors and malnutrition. Environ Res. 2008;106(2):212-8. https://doi.org/10.1016/j. envres.2007.08.005

  30. Bulka CM, Mabila SL, Lash JP, Turyk ME, Argos M. Arsenic and Obesity: A Comparison of Urine Dilution Adjustment Methods. Environ Health Perspect. 2017;125(8):087020. https://doi.org/10.1289/EHP1202

  31. Mendoza-Cano O, Sánchez-Piña RA, Barrón-Quintana J, Cuevas-Arellano HB, Escalante-Minakata P, Solano-Barajas R. Riesgos potenciales de salud por consumo de agua con arsénico en Colima, México. Salud Publica Mex. 2017;59(1):34-40. https://doi.org/10.21149/8413

  32. Fisher AT, López-Carrillo L, Gamboa-Loira B, Cebrián ME. Standards for arsenic in drinking water: Implications for policy in Mexico. J Public Health Policy. 2017;38(4):395-406. https://doi.org/10.1057/s41271-017- 0087-7

  33. Camacho LM, Gutiérrez M, Alarcón-Herrera MT, Villalba MDL, Deng S. Occurrence and treatment of arsenic in groundwater and soil in northern Mexico and southwestern USA. Chemosphere. 2011;83(3):211-25. https:// doi.org/10.1016/j.chemosphere.2010.12.067

  34. Swiss Federal Institute of Aquatic Science and Technology (Eawag). Groundwater Assessment Platform [Internet]. 2015 [cited June 25 2018]. Available from: https://www.gapmaps.org/Home/Public




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