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2020, Número 1

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Rev Latin Infect Pediatr 2020; 33 (1)


Medicamentos versátiles: buscando balas mágicas

Rosales-Hernández LA, Rivas-Larrauri FE, Yamazaki-Nakashimada MA

Idioma: Español
Referencias bibliográficas: 92
Paginas: 32-43
Archivo PDF: 355.74 Kb.


RESUMEN

La autoinmunidad y la inmunodeficiencia eran consideradas previamente condiciones mutuamente excluyentes, sin embargo, con el avance en el entendimiento de los mecanismos reguladores y del análisis genético se ha encontrado que la relación es más estrecha de lo previsto. Un paciente puede presentar manifestaciones infecciosas y autoinmunes simultáneamente. Así, existen medicamentos polifacéticos (llamados «balas mágicas» por Paul Ehrlich) que han demostrado propiedades inmunomoduladoras y antimicrobianas que pueden ser de utilidad. En este artículo se revisan los mecanismos antiinfecciosos de fármacos utilizados rutinariamente como inmunosupresores; además de las propiedades inmunomoduladoras de antibióticos, antiparasitarios, reguladores de las vías metabólicas e inhibidores de la angiogénesis que pudiesen tener implicaciones clínicas.


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