Hargens AR, Petersen LG

Idioma: Ingles.
Referencias bibliográficas: 15
Paginas: 1-10
Archivo PDF: 520.69 Kb.

RESUMEN

In order to develop effective countermeasures to maintain the health and well-being of crew members during prolonged spaceflight, such as a mission to Mars, an integrated physiologic view is necessary. Future spacecraft to deep space will be constrained by limited volume, food, water, shelter and other resources. Thus, it’s important to understand the highest risks and to direct research into these areas. This review paper examines important risks during a 2-3 year mission to Mars with a view to provide devices and methods to integrate across many physiologic systems in an attempt to reproduce activities of daily living on Earth. Because effective hardware for artificial gravity by centrifugation may be decades away, we propose use of lower body negative pressure (LBNP) as means to simulate multiple beneficial effects of gravitational stress including blood and fluid shifts towards the feet and mechanical loading of the body. LBNP-devices are reconfigurable as wearable suits to reduce mass or combined with exercise devices to increase efficacy of exercise in weightlessness.

REFERENCIAS (EN ESTE ARTÍCULO)

1. A Midterm Assessment of Implementation of the Decadal Survey on Life and Physical Sciences Research at NASA. Washington, DC: The National Academies Press. 2018. doi.org/10.17226/24966

2. Caiozzo VJ, Rose-Gottron C, Baldwin KM, Cooper D, Adams G, Hicks J, et al. Hemodynamics and metabolic responses to hypergravity on a human-powered centrifuge. Aviat Space Environ Med. 2004;75:101-8.

3. Petersen LG, Damgaard M, Petersen JCG, Norsk P. Mechanisms of increase in cardiac output during acute weightlessness in humans. J Appl Physiol. 2011;111:407-11.

4. Pavy-Le Traon A, Heer M, Narici MV, Rittweger J, Vernikos J. From space to Earth: advances in human physiology from 20 years of bed rest studies (1986–2006). Eur J Appl Physiol. 2007;101:143–94.

5. Gabrielsen A, Johansen LB, Norsk P. Central cardiovascular pressures during graded water immersion in humans. J Appl Physiol. 1993;75:581-5.

6. Cekanaviciute E, Rosi S, Costes SV. Central Nervous System Responses to Simulated Galactic Cosmic Rays. Int J Mol Sci. 2018;19(11):E3669.doi: 10.3390/ijms19113669. Review. PubMed PMID: 30463349; PubMed Central PMCID: PMC6275046

7. Hargens AR, Richardson S. Cardiovascular adaptations, fluid shifts, and countermeasures related to space flight. Respiratory Physiology & Neurobiology. 2009;(169 Supplement): S30-S33.

8. Mader TH, Gibson CR, Pass AF, Kramer LA, Lee AG, Fogarty J, et al. Optic disc edema, globe flattening, choroidal folds, and hyperopic shifts observed in astronauts after long-duration space flight. Ophthalmology. 2011;118:2058–69.

9. Patel N, Pass A, Mason S, Gibson CR, Otto C. Optical Coherence Tomography Analysis of the Optic Nerve Head and Surrounding Structures in Long-Duration International Space Station Astronauts. JAMA Ophthalmol. 2018;136:193-200.

10. Lee AG, Mader TH, Gibson RC, Brunstetter TJ, TraverW. Space flight-associated neuro-ocular syndrome. JAMA Ophthalmol. 2017;135:992–94.

11. Stenger MB, Tarver WJ. Evidence Report: Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS). Human Research Program, Human Health Countermeasures Element, JSC; NASA; 2017.

12. Roberts DR, Albrecht MH, Collins HR, Asemani D, Chatterjee AR, Spampinato MV, et al. Effects of Spaceflight on Astronaut Brain Structure as indicated on MRI. N Engl J Med. 2017;377:1746-53.

13. Roberts DR, Petersen LG. The study of hydrocephalus associated with long-term spaceflight (HALS) provides new insights into CSF flow dynamics. JAMA Neurol; 2019.

14. Petersen LG, Lawley JS, Lilja-Cyron A, Petersen JCG, Howden EJ, Sarma S, et al. Lower Body Negative Pressure to Safely Reduce Intracranial Pressure. J Phys. 2018;597:237-48.

15. Watenpaugh DE, Ballard RE, Breit GA, Hargens AR. Self-generated lower body negative pressure exercise. Aviat Space Environ Med. 1999;70(5):522-6.