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2006, Número 1

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Rev Inst Nal Enf Resp Mex 2006; 19 (1)


Implicaciones de los polimorfismos de un solo nucleótido en Mycobacterium tuberculosis y humanos en el manejo clínico de la tuberculosis

Castillejos LMJ, Pérez PR, Quiñones FF, García Sancho FMC

Idioma: Español
Referencias bibliográficas: 46
Paginas: 38-46
Archivo PDF: 74.84 Kb.


RESUMEN

Se analizan estudios de los polimorfismos genéticos de Mycobacterium tuberculosis asociados a resistencia y transmisión, así como los polimorfismos genéticos en humanos con asociación a gravedad y formas clínicas de la enfermedad y toxicidad hepática al tratamiento antituberculosis, y su utilidad en el estudio de los pacientes con tuberculosis multifarmacorresistente. Los nuevos métodos que ofrece la medicina genómica para la investigación en tuberculosis permiten sugerir nuevos criterios de aplicación inmediata en el manejo clínico de los pacientes con tuberculosis, en la evaluación de la eficacia de la terapéutica y en la prevención de eventos adversos para el paciente. Por ello, es importante evaluar el costo-beneficio de estas herramientas para fortalecer los centros de atención a pacientes con tuberculosis en países en desarrollo donde existen elevadas tasas de la enfermedad.


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