2019, Número 3
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Arch Neurocien 2019; 24 (3)
Circuitos corticales, su conectividad funcional y procesos cognitivos en el trastorno comórbido; obsesivo compulsivo y depresivo mayor
Minotta-Valencia L, Minotta-Valencia C
Idioma: Ingles.
Referencias bibliográficas: 63
Paginas: 44-52
Archivo PDF: 323.84 Kb.
RESUMEN
Introducción: El presente trabajo lleva a cabo una revisión de la literatura a través de la
cual se exploran la rumiación y los pensamientos negativos repetitivos como mecanismos
de mantenimiento de la sintomatología en el paciente con trastorno obsesivo compulsivo
(TOC) y/o trastorno depresivo mayor (TDM). Se toma como muestra, estudios que datan
entre 2010 y 2018 que miden patrones de activación corticales relacionados a procesos
de control cognitivo, y procesamiento autorreferencial, codificación en memoria, mientras
se realizan tareas, incluyendo entre sus métodos, la resonancia magnética funcional,
niveles de oxigenación en sangre y comparativos en cuanto a participantes; sujetos con
diagnóstico de depresión vs control, comparativos en cuanto a aplicación de tratamiento
medicamentoso o comportamental. Se llega a la conclusión de que la fenomenología
observable de ambos trastornos cuando se presentan juntos, integran patrones de
conectividad armónicos con unas mismas funciones transdiagnóticas de base, compatibles
con potenciales que transcurren en paralelo hiperactivando conjuntamente ciertas zonas
cerebrales, cuyo modo alterado de funcionamiento se devela como el sustrato de base
sobre el cual, es posible explicar alteraciones de procesos de control inhibitorio como
funciones ejecutivas, memoria operativa y desregulación de la arquitectura del sueño.
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