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2019, Número 5

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Gac Med Mex 2019; 155 (5)


Microbiota bacteriana intestinal en pacientes mexicanos con inmunodeficiencia común variable

Franco-Esquivias AP, García-De la Peña C, Torres-Lozano C, Vaca-Paniagua F, Díaz-Velásquez C, Ortega-Cisneros M, Quintero-Ramos A

Idioma: Español
Referencias bibliográficas: 38
Paginas: 481-486
Archivo PDF: 306.54 Kb.


RESUMEN

Introducción: La inmunodeficiencia común variable (IDCV) es la principal inmunodeficiencia primaria sintomática y cursa con alteraciones inmunes complejas. La microbiota intestinal interactúa estrechamente con el sistema inmune y la disbiosis intestinal está relacionada con múltiples patologías. Objetivo: Describir por primera vez la composición de la microbiota intestinal en pacientes mexicanos con inmunodeficiencia común variable. Método: Se recolectaron muestras fecales de cinco pacientes con inmunodeficiencia común variable y se llevó a cabo secuenciación masiva de la región V3-V4 del gen 16S rRNA mediante tecnología Illumina. Resultados: Se observó abundancia bacteriana relativa a todos los niveles taxonómicos. Firmicutes, Actinobacteria y Verrucomicrobia fueron los filos predominantes. La clase Clostridia y el orden Clostridiales fueron los principales en su respectivo taxón; predominó la familia Ruminococcaceae. Se reportaron 166 géneros, el más abundante fue Faecalibacterium. Se identificaron cinco especies, pero solo Bifidobacterium longum estuvo presente en todos los pacientes. Conclusiones: A diferencia de la microbiota intestinal de sujetos sanos en quienes predominan Firmicutes y Bacteroidetes, en los pacientes con inmunodeficiencia común variable considerados en este estudio fueron abundantes Firmicutes, Actinobacterias y Verrucomicrobia. La baja abundancia de bacteroidetes y alta de firmicutes podrían significar disbiosis intestinal.


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