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2019, Número 1

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Revista Habanera de Ciencias Médicas 2019; 18 (1)


La inflamación desde una perspectiva inmunológica: desafío a la Medicina en el siglo XXl

González-Costa M, Padrón GAA

Idioma: Español
Referencias bibliográficas: 45
Paginas: 30-44
Archivo PDF: 732.99 Kb.


RESUMEN

Introducción: La inflamación es una respuesta homeostática del organismo. Es uno de los principales motivos de consulta en Cuba y el mundo. Existe una percepción errónea de que es una entidad aislada y siempre patológica. Es un proceso dinámico, complejo, sistémico y multifactorial. Por eso constituye un reto el dilucidar los elementos, cambios tisulares que causa y cómo proceder en la clínica ante un cuadro inflamatorio.
Objetivo: Describir la inflamación, su clasificación, elementos involucrados y cambios sistémicos desde una perspectiva inmunológica.
Material y Métodos: Se realizó una revisión sobre el tema empleando la bibliografía actualizada y luego se consultaron artículos de libre acceso en las bases de datos Pubmed y Scielo en el período de enero de 2013 a diciembre. Desarrollo: La inflamación puede clasificarse según el daño, tiempo o los efectores involucrados. Las principales moléculas son las citocinas como TNF-α, IFN-γ, IL-1β, IL-10, IL-6, TGF-β. Participan células como los neutrófilos, mastocitos, macrófagos, linfocitos T y las del endotelio vascular. Durante el proceso inflamatorio se modifican las funciones de casi todos los sistemas de órganos. En ciertos tipos de inflamación, es la respuesta adaptativa quien origina y perpetúa el proceso inflamatorio.
Conclusiones: En la actualidad se desconocen los acontecimientos que desencadenan inflamación crónica y cómo ocurre el daño tisular. El mayor desafío consiste en dilucidar las causas y mecanismos inmunológicos que conllevan a las manifestaciones inflamatorias sistémicas que se manifiestan como enfermedades neurológicas, cardiovasculares y autoinmunes, entre otras.


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