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Colegio de Medicina Interna de México.

2019, Número 2

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Med Int Mex 2019; 35 (2)


Vasculitis leucocitoclástica (vasculitis por hipersensibilidad)

Hernández-López A, Panigua-Tapia MU, Cortés-Rojo C, Rodríguez-Orozco AR

Idioma: Español
Referencias bibliográficas: 108
Paginas: 251-267
Archivo PDF: 284.90 Kb.


RESUMEN

La vasculitis leucocitoclástica es un trastorno autoinmunitario que afecta pequeños vasos y provoca inflamación, destrucción y necrosis de los mismos; con frecuencia es subdiagnosticada. La causa es multifactorial, la fisiopatología es compleja y los inmunomoduladores son los medicamentos más importantes en su tratamiento. Este artículo tiene por objetivo revisar el estado actual del conocimiento en vasculitis leucocitocástica con insistencia en el diagnóstico y tratamiento. Se revisaron artículos publicados en el periodo comprendido entre 1990 y 2017. Los navegadores fueron Google Crome y Firefox y el motor de búsqueda fue Scholar google. Las bases de datos consultadas fueron: MEDLINE, RIMA Astra-Zeneca y las guías de práctica clínica del sistema de salud mexicano (CENETEC). Se revisaron 108 publicaciones relevantes para el tema, priorizando las pertenecientes a revistas indizadas en MEDLINE y Science Citation Index-JCR. Se requieren estudios para integrar subgrupos clínicos y de tratamiento e investigar los mecanismos de daño tisular en cada subgrupo. La inmunomodulación juega un papel central en el tratamiento.


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