2019, Número 3
<< Anterior Siguiente >>
salud publica mex 2019; 61 (3)
Tabaquismo y cáncer de pulmón
Zinser-Sierra JW
Idioma: Español
Referencias bibliográficas: 34
Paginas: 303-307
Archivo PDF: 268.55 Kb.
RESUMEN
El tabaquismo es la principal causa de cáncer de pulmón. Participa
en la etiología y, dependiendo de la intensidad y duración,
influye en el tipo histológico, el estadio de la enfermedad y
el efecto del tratamiento, por lo que nunca es tarde para
dejar de fumar. La toxicidad del humo del tabaco es tan alta
que no existe ninguna modalidad segura de tabaquismo. Los
filtros, las diferentes variedades de cigarros light, los puros,
pipas de agua, etc. son prohibitivamente dañinas. Inclusive los
diferentes dispositivos electrónicos para la administración de
nicotina, además de promocionar la adicción, tienen efectos
respiratorios y cardiovasculares a corto plazo y, aunque aún
es pronto para conocer sus consecuencias a largo plazo, se
han identificado efectos en la proliferación celular y progresión
tumoral. Por lo anterior, las campañas para el control
del tabaquismo deben considerar estos productos como su
principal amenaza.
REFERENCIAS (EN ESTE ARTÍCULO)
Morabia A. Quality, originality, and significance of the 1939 “Tobacco consumption and lung carcinoma” article by Mueller, including translation of a section of the paper. Prev Med. 2012;55(3):171-7. https://doi. org/10.1016/j.ypmed.2012.05.008
Doll R, Hill B. Smoking and carcinoma of the lung. BMJ. 1950;2:739-48. https://doi.org/10.1136/bmj.2.4682.739
Wynder EL, Graham EA. Tobacco smoking as a possible etiologic factor in bronchogenic carcinoma. A study of six hundred and eightyfour proved cases. JAMA. 1950;143(4):329-36. https://doi.org/10.1001/ jama.1950.02910390001001
Bergen AW, Caporaso N. Cigarette smoking. JNCI. 1999;91(16):1365-75. https://doi.org/10.1093/jnci/91.16.1365
Fisher RA. Dangers of Cigarette-smoking. Br Med J. 1957;2:43. https:// doi.org/10.1136/bmj.2.5035.43
Editorial board. Cancer of the lung. Editorial. N Engl J Med. 1953;249(11):465-6. https://doi.org/10.1056/NEJM195309102491110
Hecht SS. Tobacco smoke carcinogens and lung cancer. JNCI. 1999;91(14):1194-210. https://doi.org/10.1093/jnci/91.14.1194
Wiencke JK, Thurston SE, Kelsey KT, Varkonyi A, Wain JC, Mark EJ, Christiani DC. Early age at smoking initiation and tobacco carcinogen DNA damage in the lung. JNCI. 1999;91(7):614-9. https://doi.org/10.1093/ jnci/91.7.614
Tammemägi MC, Katki HA, Hocking WG, Church TR, Caporaso N, Kvale PA, et al. Selection criteria for lung-cancer screening. N Engl J Med. 2013;368:728-36. https://doi.org/10.1056/NEJMoa1211776
Thorgeirsson TE, Geller F, Sulem P, Rafnar T, Wiste A, Magnusson KP, et al. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature. 2008;452:638-41. https://doi.org/10.1038/ nature06846
Kenfield SA, Wei EK, Stampfer MJ, Rosner BA, Colditz GA. Comparison of aspects of smoking among the four histological subtypes of lung cancer. Tob Control. 2008;17:198-204. https://doi.org/10.1136/tc.2007.022582
Hoffmann D, Djordjevic MV, Hoffmann I. The changing cigarette. Prev Med. 1997;26:427-34. https://doi.org/10.1006/pmed.1997.0183
Swanton C, Govindan R. Clinical implications of genomic discoveries in lung cancer. N Engl J Med. 2016;374:1864-73. https://doi.org/10.1056/ NEJMra1504688
Harris JE, Thurn MJ, Mondul AM, Calle EE. Cigarette tar yields in relation to mortality from lung cancer in the cancer prevention study II prospective cohort, 1982-8. BMJ. 2004;328:72. https://doi.org/10.1136/ bmj.37936.585382.44
Tindle HA, Shiffman S, Hartman AM, Bost JE. Switching to ‘‘lighter’’ cigarettes and quitting smoking. Tob Control. 2009;18:485-90. https://doi. org/10.1136/tc.2008.029314
Kobrinsky NL, Klug MG, Hokanson PJ, Sjolander DE, Burd L. Impact of smoking on cancer stage at diagnosis. J Clin Oncol. 2003;21(5):907-13 https://doi.org/10.1200/JCO.2003.05.110
Videtic GM, Stitt LW, Dar AR, Kocha WI, Tomiak AT, Truong PT, et al. Continued cigarette smoking by patients receiving concurrent chemoradiotherapy for limited stage small cell lung cancer is associated with decreased survival. J Clin Oncol. 2003;21(8):1544-9. https://doi.org/10.1200/ JCO.2003.10.089
Iribarren C, Tekawa IS, Sidney S, Friedman GD. Effect of cigar smoking on the risk of cardiovascular disease, chronic obstructive pulmonary disease and cancer in men. N Engl J Med. 1999;340:1773-80. https://doi. org/10.1056/NEJM199906103402301
Shihadeh A, Azar S, Antonios C, Haddad A. Towards a topographical model of narghile water-pipe café smoking: a pilot study in a high socioeconomic status neighborhood of Beirut, Lebanon. Pharmacol Biochem Behav. 2004;79(1):75-82. https://doi.org/10.1016/j.pbb.2004.06.005
St Helen G, Benowitz NL, Dains KM, Havel C, Peng M, Jacob P 3 rd. Nicotine and carcinogen exposure after water pipe smoking in hookah bars. Cancer Epidemiol Biomarkers Prev. 2014;23:1055-66. https://doi. org/10.1158/1055-9965.EPI-13-0939
Wang MP, Ho SY, Leung LT, Lam TH. Electronic cigarette use and respiratory symptoms in chinese adolescents in Hong Kong. JAMA Pediatr. 2016;170(1):89-91. https://doi.org/10.1001/jamapediatrics.2015.3024
Martin E, Clapp PW, Rebuli ME, Pawlak EA, Glista-Baker E, Benowitz NL, et al. E-cigarette use results in suppression of immune and inflammatory- response genes in nasal epithelial cells similar to cigarette smoke. Am J Physiol Lung Cell and Mol Physiol. 2016;311(1):L135-44. https://doi. org/10.1152/ajplung.00170.2016
Benowitz NL, Fraiman JB. Cardiovascular effects of electronic cigarettes. Nature Rev Cardiol. 2017;14(8):447-56. https://doi.org/10.1038/ nrcardio.2017.36
Behar RZ, Wang Y, Talbot P. Comparing the cytotoxicity of electronic cigarette fluids, aerosols and solvents. Tob Control. 2018;27:325-33. https://doi.org/10.1136/tobaccocontrol-2016-053472
Kosmider L, Sobczak A, Prokopowicz A, Kurek J, Zaciera M, Knysak J, et al. Cherry-flavoured electronic cigarettes expose users to the inhalation irritant benzaldehyde. Thorax. 2016;71(4):376-7. https://doi.org/10.1136/ thoraxjnl-2015-207895
Cameron JM, Howell DN, White JR, Andrenyak DM, Layton ME, Roll JM. Variable and potentially fatal amounts of nicotine in e-cigarette nicotine solutions. Tob Control. 2014;23:77-8. https://doi.org/10.1136/ tobaccocontrol-2012-050604
Moheimani RS, Bhetraratana M, Yin F, Peters KM, Gornbein J, Araujo JA, Middlekauff HR. Increased cardial sympathetic activity and oxidative stress in habitual electronic cigarette users. JAMA Cardiol. 2017;2(3):278-84. https://doi.org/10.1001/jamacardio.2016.5303
Schaal C, Chellappan SP. Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers. Mol Cancer Res. 2014;12(1):14-23. https://doi.org/10.1158/1541-7786.MCR-13-0541
Davies CD, Ismail A. Nicotine has deleterious effects on wound healing through increased vasoconstriction. BMJ. 2016;353:i2709. https://doi. org/10.1136/bmj.i2709
Beard E, West R, Michie S, Brown J. Association between electronic cigarette use and changes in quit attempts, success of quit attempts, use of smoking cessation pharmacotherapy and use of stop smoking services in England: time series analysis of population trends. BMJ. 2016;354:i4645 https://doi.org/10.1136/bmj.i4645
Mayor S. E-cigarettes may be reversing fall in teenage smoking, study finds. BMJ. 2016;354:i3838. https://doi.org/10.1136/bmj.i3838
Kandel ER, Kandel DB. A molecular basis for nicotine as a gateway drug. N Engl J Med. 2014;371:2038-9. https://doi.org/10.1056/NEJMc1411785
Audrain-McGovern J, Stone MD, Barrington-Trimis J, Unger JB, Leventhal AM. Adolescent e-cigarette, hookah and conventional cigarette use and subsequent marijuana use. Pediatrics. 2018;142(3)e20173616. https:// doi.org/10.1542/peds.2017-3616
Organización Mundial de la Salud. Convenio Marco de la OMS para el Control del Tabaco. Ginebra: OMS, 2003. Disponible en: https://www.who. int/tobacco/framework/WHO_fctc_spanish.pdf