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Órgano Oficial del Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz

2019, Número 2

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Salud Mental 2019; 42 (2)


Cognitive and spectral coherence of EEG alterations in resting state in children with chronic TBI

Galicia-Alvarado M, Alducin-Castillo J, Ramírez-Flores MJ, Sánchez Quezada AL, Yáñez-Suárez O, Flores-Ávalos B

Idioma: Ingles.
Referencias bibliográficas: 84
Paginas: 91-100
Archivo PDF: 672.58 Kb.


RESUMEN

Introducción. El TCE se asocia con alteraciones en la conectividad cortico-subcortical. Sin embargo, se ha prestado poca atención a las características clínicas y de conectividad funcional en pacientes pediátricos con TCE crónico. Objetivo. Evaluar el desempeño cognitivo y la coherencia espectral de un grupo de niños con TCE en fase no aguda. Método. Estudio transversal de 15 niños con TCE y 17 niños controles. Se empleó la Evaluación Neuropsicológica Infantil (ENI) y se registró la actividad en reposo del EEG con ojos cerrados. Fuera de línea, se eligieron épocas de 2 s del trazo de cada participante y se estimó la coherencia espectral en un rango de 1.6 a 30 Hz. Se comparó el rendimiento cognitivo entre los grupos con la prueba T/U-Mann de Whitney y MANOVA para los valores de coherencia. Resultados. El grupo con TCE mostró un menor rendimiento (p ≤ 0.05) en habilidades metalingüísticas, visuoespaciales, atención, memoria, flexibilidad no verbal, planeación y organización. Se encontraron diferencias (p ≤ 0.000) en la coherencia espectral tanto inter como intrahemisférica entre los grupos. Particularmente, en F1-F3 (95%IC: 0.543 - 0.557) en todo el rango de frecuencias y F3-C3 (95%IC: 0.503 - 0.515) en delta, theta, alfa2 y beta. Discusión y conclusión. Los resultados sugieren que distintas redes en estado de reposo muestran alteraciones de hipo e hiperconectividad funcional aun después de varios años de un TCE. Es probable que una sutil diferencia en el grado de conectividad sea determinante en la génesis o el desarrollo exitoso de procesos atencionales, mnésicos, ejecutivos y visoespaciales.


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