Espinola‑Zavaleta N, Enríquez‑Rodríguez LE, Miranda‑Chávez I, Masso‑Bueso JS, Carvajal‑Juárez I, Alexanderson‑Rosas E,  Meave‑González A

Idioma: Ingles.
Referencias bibliográficas: 49
Paginas: 26-30
Archivo PDF: 218.84 Kb.

RESUMEN

Introducción: El síndrome metabólico (SM) es un factor de riesgo para el desarrollo de enfermedad cardiovascular. Objetivo: Comparar la función endotelial y el grosor íntima-media en niños con SM y niños sanos, para determinar la existencia de mecanismos de aterosclerosis temprana. Material y métodos: Estudio transversal que incluyó dos grupos: 15 niños con SM y 15 sanos. Se determinó: presión sistólica de la arteria pulmonar (PSAP), vasodilatación mediada por flujo (VMF) y grosor íntima-media (GIMc). Resultados: La VMF en niños con SM fue inferior a la de los sanos (8.7±1.6% vs 12.9±1.2%, p‹0.0001). En el 73% de niños con SM y en el 13% de sanos la VMF fue menor al 10%. El GIMc fue mayor en SM (0.06±0.002 vs 0.034±0.005, p‹0.001). En SM la PSAP fue mayor (37.8±14.4 vs 23.2±5.31, p‹0.002). Existió correlación negativa entre la VMF y el GIMc (r:-0.562). Conclusiones: Los niños con SM tuvieron una VMF disminuida, incremento en el GIMc y PSAP, lo cual podría relacionarse con aterosclerosis temprana.

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