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2019, Número 1

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Rev Hosp Jua Mex 2019; 86 (1)


Frecuencia de los polimorfismos E23K (KCNJ11) y R1273R (ABCC8) en pacientes con diabetes mellitus tipo 2: asociación del control glucémico en pacientes tratados con hipoglucemiantes orales

Rodríguez-Rivera NS, Cuautle-Rodríguez P, Ortiz-López MG, Granados-Silvestre MÁ, Menjívar-Iraheta M, Molina-Guarneros J

Idioma: Español
Referencias bibliográficas: 52
Paginas: 17-25
Archivo PDF: 242.94 Kb.


RESUMEN

La diabetes mellitus tipo 2 es una enfermedad muy heterogénea, con una tasa de respuesta a los diferentes fármacos muy diversa; cerca del 75% de los pacientes en tratamiento no están controlados de acuerdo con datos de ENSANUT 2006, 2012 y MC 2016. Se han descrito polimorfismos asociados con riesgo de padecer esta enfermedad en varias poblaciones que podrían estar también relacionados con variaciones en la respuesta farmacológica de los pacientes. Las sulfonilureas están entre los fármacos más utilizados para el control de la diabetes; los polimorfismos en los genes que codifican para el canal blanco de estos fármacos KCNJ11 y ABCC8 podrían estar relacionados con estas variaciones. En México, existe poca información acerca de la frecuencia de estos polimorfismos en la población en general y diabéticos. Se genotipificaron 80 pacientes diabéticos en tratamiento con hipoglucemiantes orales para los polimorfismos E23K (KCNJ11) y R1273R (ABCC8) mediante PCR-RFLP. Las frecuencias genotípicas y alélicas obtenidas fueron comparadas con las reportadas para las principales poblaciones mundiales y con las de diabéticos encontrando que son diferentes a la mayoría de las poblaciones descritas. No se detectó asociación en nuestros datos entre E23K y R1273R con el control glucémico de los pacientes.


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