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Antes Revista del Instituto Nacional de Enfermedades Respiratorias

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2018, Número 4

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Neumol Cir Torax 2018; 77 (4)


Determinantes de patogenicidad en el virus de influenza pandémico en México: Factores virales asociados con la severidad

Mejía-Nepomuceno F, Martínez-Maldonado F, Pérez-Padilla R, Vázquez-Pérez JA

Idioma: Español
Referencias bibliográficas: 45
Paginas: 297-304
Archivo PDF: 354.80 Kb.


RESUMEN

El virus de influenza causa por lo común infecciones estacionales y ocasionalmente pandemias, provocando un aumento en la morbimortalidad de las enfermedades respiratorias en los humanos. El virus de influenza tiene la habilidad de adaptarse a varios hospederos, circulando de manera normal y constante en aves acuáticas, aves de corral, cerdos, caballos y humanos. La interacción de diferentes subtipos virales en estos hospederos puede generar nuevas variantes. Aunado a esto se presentan de forma natural mutaciones puntuales en todos los genes del virus, que pueden conferir ventajas en la replicación viral, adaptación, así como en la evasión del sistema inmunológico, emergiendo variantes virales con la probabilidad de ser más patogénicos. Caracterizar los determinantes de patogenicidad permite monitorear y detectar de manera temprana aquellas posibles cepas que puedan generar una amenaza en la población humana, contribuyendo con esto en la identificación molecular de los posibles cambios en el genoma del virus de influenza, correlacionándola con la virulencia y la patogenicidad del virus.


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