Sánchez-Valle V, Méndez-Sánchez N

Idioma: Español
Referencias bibliográficas: 37
Paginas: 161-168
Archivo PDF: 154.13 Kb.

RESUMEN

La generación de especies reactivas de oxígeno y otros radicales libres son un proceso normal durante el metabolismo celular, el cual está compensado por un complejo sistema antioxidante. Sin embargo, la exposición a contaminantes, medio ambiente, estilo de vida y situaciones patológicas, pueden generar exceso y acumulación de radicales, resultando en el establecimiento de estrés oxidativo. El estrés oxidativo se ha relacionado con el envejecimiento y enfermedades crónicas, promoviendo un alto índice de mortalidad en los últimos años. Los antioxidantes son compuestos que impiden los procesos de oxidación y, por lo tanto, retrasan o previenen el estrés oxidativo. En este artículo se examina de forma general el proceso de estrés oxidativo y las vías por las que refiere a múltiples enfermedades crónicas. También se analizará el papel de los antioxidantes en el control de la oxidación, revisando la evidencia bibliográfica de su participación en la prevención de enfermedades.

REFERENCIAS (EN ESTE ARTÍCULO)

1. Poljsak B. Strategies for reducing or preventing the generation of oxidative stress. Oxid Med Cell Longev 2011; 2011: 194586.

2. Halliwell B. Biochemistry of oxidative stress. Biochemical Society Transactions 2007; 35: 1147-50.

3. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007; 39: 44-84.

4. Dröge W. Free radicals in the physiological control of cell function. Physiol Rev 2002; 82: 47-95.

5. Halliwell B. Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life. Plant Physiology 2006; 41: 312-22.

6. Halliwell B, Gutteridge JMC. Antioxidans of human extracellular fluids. Arch Biochem Biophys 1990; 280: 1-8.

7. Valko M, Morris H, Cronin MTD. Metals, toxicity and oxidative stress. Curr Med Chem 2005; 12: 1161-208.

8. Maron BA, Michel T. Subcellular localization of oxidants and redox modulation of endothelial nitric oxide synthase. Circulation J 2012; 76: 2497-512.

9. Anderson BO, Brown JM, Harken A. Mechanisms of neutrophilmediated tissue injury. J Surg Res 1991; 51: 170-9.

10. Fusco D, Colloca G, Lo Monaco MR, Cesari M. Effects of antioxidant supplementation on the aging process. Clin Interv Aging 2007; 2: 377-87.

11. Bonnefoy M, Drai J, Kostka T. Antioxidants to slow aging, facts and perspectives. Presse Med 2002; 31: 1174-84.

12. Lachance PA, Nakat Z, Jeong WS. Antioxidants: an integrative approach. Nutrition 2001; 17: 835-8.

13. Stadtman ER, Olivere CN. Metal-catalyzed oxidation of protein. Physiological Consequences. J Biol Chem 1991; 266: 2005-8.

14. Soong NW, Hinton DR, Cortopassi G, Arnheim N. Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. Nat Genet 1994; 2: 318-23.

15. Gandhi S, Abramov AY. Mechanism of Oxidative Stress in Neurodegeneration. Oxid Med Cell Longev 2012; 2012: 428010.

16. Martin HL, Teismann P. Glutathione - A review on its role and significance in Parkinson’s disease. FASEB Journal 2009; 10: 3263-72.

17. Aksoy H, Dean G, Elian M, Deng HX, Deng G, Juneja T, Storey E, et al. A4T mutation in the SOD1 gene causing familial amyotrophic lateral sclerosis. Neuroepidemiology 2003; 4: 235-8.

18. Gavrieli Y, Sherman Y, Ben-Sasson SA. ldentification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J Cell Biol 1992; 119: 493-501.

19. Sánchez-Valle V, Valverde M, Carrizale L, Mejía J, Zepeta N, Rojas E. A metal mixture induces transformation upon antioxidant depletion in a hepatic cell line. Ann Hepatol 2013; 12: 315-2.

20. Jimenez-Del-Rio M, Velez-Pardo C. The Bad, the Good, and the Ugly about Oxidative Stress. Oxid Med Cell Longev 2012; 2012: 163913.

21. De Marchi E, Baldassari F, Bononi A, Wieckowski MR, Pinton P. Oxidative stress in cardiovascular diseases and obesity: role of p66Shc and protein kinase C. Oxid Med Cell Longev 2013; 2013: 564961.

22. Yasumari K, Maeda K, Nakamura M, Yoshikawa J. Oxidative Stress in leukocytes is a posible link between blood pressure, blood glucose and C-reactive protein. Hypertension 2002; 39: 777-80.

23. Orie NN, Sidec W, Tepel M. Reactive oxygen species in essential hypertension and non-insulin-dependent diabetes mellitus. Am J Hypertens 1999; 12: 1169-74.

24. Blankenberg S, Rupprecht HJ, Bickel C, Torzewski M, Hafner G, Tiret L, Smieja M, et al. Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease. Engl J Med 2003; 49: 1605-13.

25. Serviddio G, Pereda J, Pallardó FV, Carretero J, Borras C, Cutrin J, Vendemiale G, et al. Ursodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress. Hepatology 2004; 39: 711-20.

26. Marí M, Colell A, Morales A, von Montfort C, Garcia-Ruiz C, Fernández-Checa JC. Redox Control of Liver Function in Health and Disease. Antioxidants redox signaling 2010; 12: 1295- 331.

27. Choi KM, Gibbons SJ, Nguyen TV, Stoltz GJ, Lurken MS, Ordog T, Szurszewski JH, et al. Heme oxygenase-1 protects interstitial cells of Cajal from oxidative stress and reverses diabetic gastroparesis. Gastroenterology 2008; 135: 2055-64.

28. Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction? Diabetes 2003; 52: 1-8.

29. Bravi MC, Pietrangeli P, Laurenti O, Basili S, Cassone-Faldetta M, Ferri C, De-Mattia G. Polyol pathway activation and glutathione redox status in non-insulin-dependent diabetic patients. Metabolism 1997; 46: 1194-8.

30. Pitocco D, Zaccardi F, Di Stasio E, Romitelli F, Santini SA, Zuppi C, Ghirlanda G. Oxidative Stress, Nitric Oxide, and Diabetes. The review of diabetic studies 2010; 7: 15-25.

31. Halliwell B. Free radicals and antioxidants: updating a personal view. Nutr Rev 2012; 70: 257-65.

32. Willcox JK, Ash SL, Catignani GL. Antioxidants and prevention of chronic disease. Crit Rev Food Sci Nutr 2004; 44: 275-95.

33. Guo F, Monsefi N, Moritz A, Beiras-Fernandez A. Selenium and cardiovascular surgery: an overview. Curr Drug Saf 2012; 7: 321-7.

34. Michaud DS, Feskanich D, Rimm EB, Colditz GA, Speizer FE, Willett WC, Giovannucci E. Intake of specific carotenoids and risk of lung cancer in 2 prospectives US cohorts. Am J Clin Nutr 2000; 72: 990-7.

35. Nagao N, Nakayama T, Etoh T, Saiki I, Miwa N. Tumor invasion is inhibited by phosphorylated ascorbate via enrichment of intracelular vitamin C and decreasing of oxidative stress. J Cancer Res Clin Oncol 2000; 126: 511-8.

36. Ha HL, Shin HJ, Feitelson MA, Yu DY. Oxidative stress and antioxidants in hepatic pathogenesis. World J Gastroenterol 2010; 16: 6035-43.

37. Lahoz C, Peña R, Mostaza JM. ¿Se debe recomendar antioxidantes para la prevención cardiovascular? Rev Clin Esp 2000; 200: 212-7.