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2018, Número 1

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Med Crit 2018; 32 (1)


Alteraciones de la hemostasia en el enfermo con quemaduras

Carrillo ER, Tamez CA, Garnica EMA, Sánchez PH, Carrillo CDM, Carrillo CCA

Idioma: Español
Referencias bibliográficas: 46
Paginas: 41-47
Archivo PDF: 159.52 Kb.


RESUMEN

Las quemaduras graves se asocian a coagulopatía, que semeja a la que se presenta en trauma y sepsis. Se caracteriza por un desbalance procoagulante-anticoagulante e hiperactividad del sistema fibrinolítico. Es secundaria a hemodilución, hipotermia, inflamación, hipoperfusión tisular y lesión endotelial. La presencia de coagulopatía es un factor de riesgo en el incremento de morbimortalidad. A pesar de estar bien reconocida, no hay guías específicas para su abordaje y tratamiento, pero se han propuesto diferentes medidas y esquemas terapéuticos guiados por objetivos, semejantes a los recomendados para la coagulopatía en trauma.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Izaguirre RA. Centenario de la doctrina de la coagulación sanguínea. Arch Cardiol Mex. 2005;75(3):118-129.

  2. Osorioz JH, Quenan YE, Borja GW. Evolución y cambios en el sistema de la coagulación sanguínea. Una reflexión. Rev Univ Salud. 2013;15(2):225-237.

  3. Góngora-Biachi RA. La sangre en la historia de la humanidad. Rev Biomed. 2005;16:281-288

  4. Alvarado AI. Fisiología de la coagulación: nuevos conceptos aplicados al cuidado perioperatorio. Univ Med. 2013;54(3):338-352.

  5. Jobling L, Eyre L. Hemostasis, blood platelets and coagulation. Anaesth Intens Care Med. 2013;14(2):51-53.

  6. Austin S. Hemostasis. Med. 2009;37(3):133-136.

  7. Gómez BR, Guerra AT, Dita SL, Fernández AJ, Cabrera ZM. Teoría celular de la coagulación: de las cascadas a las membranas celulares. MediSur. 2011;9(2):65-74.

  8. Páramo JA, Panizo E, Pegenaute C, Lecumberri VR. Coagulación 2009: una visión moderna de la hemostasia. Rev Med Univ Navarra. 2009;53(1):19-23.

  9. Carrillo ER, González SJ. Inflamación-endotelio-coagulación en sepsis. Conceptos actuales. Cir Ciruj. 2002;70(6):433-441.

  10. Park MS, Salinas J, Wade CE, Wang J, Martini W, Pusateri AE, et al. Combining early coagulation and inflammatory status improves prediction of mortality in burned and nonburned trauma patients. J Trauma. 2008;64(2 Supl.):188-194.

  11. Frink M, Pape HC, van Griensven M, Krettek C, Chaudry IH, Hildebrand F. Influence of sex and age on MODS and cytokines after multiple injuries. Shock. 2007;27(2):151-156.

  12. Mace JE, Park MS, Mora AG, Chung KK, Martini W, White CE, et al. Differential expression of the immunoinflammatory response in trauma patients: burn vs non-burn. Burns. 2012;38(4):599-606.

  13. Jeschke MG, Mlcak RP, Finnerty CC, Norbury WB, Gauglitz GG, Kulp GA, et al. Burn size determines the inflammatory and hypermetabolic response. Crit Care. 2007;11(4):R90.

  14. Schaden E, Hoerburger D, Hacker S, Kraincuk P, Baron DM, Kozek-Langenecker S. Fibrinogen function after severe burn injury. Burns. 2012;38(1):77-82.

  15. García-Avello A, Lorente JA, César-Pérez J, García-Frade LJ, Alvarado R, Arévalo JM, et al. Degree of hypercoagulability and hyperfibrinolysis is related to organ failure and prognosis after burn trauma. Thromb Res. 1998;89(2):59-64.

  16. Niedermayr M, Schramm W, Kamolz L, Andel D, Römer W, Hoerauf K, et al. Antithrombin deficiency and its relationship to severe burns. Burns. 2007;33(2):173-178.

  17. Glas GJ, Levi M, Schultz MJ. Coagulopathy and its management in patients with severe burns. J Thromb Haemost. 2016;14(5):865-874.

  18. Barret JP, Gomez PA. Disseminated intravascular coagulation: a rare entity in burn injury. Burns. 2005;31(3):354-357.

  19. Lavrentieva A, Kontakiotis T, Bitzani M, Papaioannou-Gaki G, Parlapani A, Thomareis O, et al. Early coagulation disorders after severe burn injury: impact in mortality. Intensive Care Med. 2008;34(4):700-706.

  20. Kowal-Vern A, Gamelli RL, Walenga JM, Hoppensteadt D, Sharp-Pucci M, Schumacher HR. The effect of burn wound size on hemostasis: a correlation of the hemostatic changes to the clinical state. J Trauma. 1992;33(1):50-57.

  21. Brohi K, Singh J, Heron M, Coats T. Acute traumatic coagulopathy. J Trauma. 2003;54(6):1127-1130.

  22. Brohi K, Cohen MJ, Davenport RA. Acute coagulopathy of trauma: mechanism, identificaction and effect. Curr Opin Crit Care. 2007;13(6):680-685.

  23. King DR, Namias N, Andrews DM. Coagulation abnormalities following thermal injury. Blood Coagul Fibrinolysis. 2010;21(7):666-669.

  24. Hoffman MM, Monroe DM 3rd. A cell-based model of hemostasis. Tromb Haemost. 2001;85(6):958-965.

  25. Carrillo ER, Villaseñor OP. Coagulopatía del paciente quirúrgico. El nuevo modelo celular de la coagulación y su aplicación en anestesiología. Rev Mex Anest. 2004;27(4):219-230.

  26. Maegele M, Lefering R, Yucel N, Tjardes T, Rixen D, Paffrath T, et al. Early coagulopathy in multiple injury: analysis from the German Trauma Registry on 8724 patients. Injury. 2007;38(3):298-304.

  27. Brohi K. Diagnosis and management of coagulopathy after major trauma. BJS. 2009;96(9):963-964.

  28. Swallow RA, Agarwala RA, Dawkins KD, Curzen NP. Thromboelastography: potencial bedside tool to assess the effects of antiplatelet therapy? Platelets. 2006;17(6):385-392.

  29. George JN, Raskob GE, Shah SR, Rizvi MA, Hamilton SA, Osborne S, et al. Drug-induced thrombocytopenia: systematic review of published case reports. Ann Intern Med. 1998;129(11):886-890.

  30. Kessler CM, Khokhar N, Liu M. A systematic approach to the bleeding patient: correlation of clinical symptoms and signs with laboratory testing. Consultative hemostasis and thrombosis. 2007:17-33.

  31. Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF. Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway? Ann Surg. 2007;245(5):812-818.

  32. Mitra B, Wasiak J, Cameron PA, O’Reilly G, Dobson H, Cleland H. Early coagulopathy of major burns. Injury. 2013;44(1):400-403.

  33. Lu RP, Ni A, Lin FC, Ortiz-Pujols SM, Adams SD, Monroe DM 3rd, et al. Major burns injury is not associated with acute traumatic coagulopathy. J Trauma Acute Care Surg. 2013;74(6):1474-1479.

  34. Van Haren RM, Thorson CM, Valle EJ, Busko AM, Guarch GA, Andrews DM, et al. Hypercoagulability after burn injury. J Trauma Acute Care Surg. 2013;75(1):37-43.

  35. Müller MC, Meijers JC, Vroom MB, Juffermans NP. Utility of thromboelastography and/or thromboelastometry in adults with sepsis: a systematic review. Crit Care. 2014;18(1):R30.

  36. Hunt H, Stanworth S, Curry N, Woolley T, Cooper C, Ukoumunne O, et al. Thromboelastography (TEG) and rotational thromboelastometry (ROTEM) for trauma-induced coagulopathy in adult trauma patients with bleeding. Cochrane Database Syst Rev. 2015;(2):CD010438.

  37. Da Luz LT1, Nascimento B, Rizoli S. Thrombelastography (TEG): practical considerations on its clinical use in trauma resuscitation. Scand J Trauma Resusc Emerg Med. 2013;21:29.

  38. Ostrowski SR, Sørensen AM, Larsen CF, Johansson PI. Thrombelastography and biomarker profiles in acute coagulopathy of trauma: a prospective study. Scand J Trauma Resusc Emerg Med. 2011;19:64.

  39. Saffle JI. The phenomenon of “fluid creep” in acute burn resuscitation. J Burn Care Res. 2007;28(3):382-395.

  40. Sherren PB, Hussey J, Martin R, Kundishora T, Parker M, Emerson B. Lethal triad in severe burns. Burns. 2014;40(8):1492-1496.

  41. Kutcher ME, Howard BM, Sperry JL, Hubbard AE, Decker AL, Cuschieri J, et al. Evolving beyond the vicious triad: differential mediation of traumatic coagulopathy by injury, shock, and resuscitation. J Trauma Acute Care Surg. 2015;78(3):516-523.

  42. Watts DD, Trask A, Soeken K, Perdue P, Dols S, Kaufmann C. Hypothermic coagulopathy in trauma: effect of varying levels of hypothermia on enzyme speed, platelet function, and fibrinolytic activity. J Trauma. 1998;44(5):846-854.

  43. Singer AJ, Taira BR, Thode HC Jr, McCormack JE, Shapiro M, Aydin A, et al. The association between hipotermia, prehospital cooling, and mortality in burn victims. Acad Emerg Med. 2010;17(4):456-459.

  44. Dirkmann D, Hanke AA, Görlinger K, Peters J. Hypotermia and acidosis synergistically impair coagulation in human whole blood. Anesth Analg. 2008;106(6):1627-1632.

  45. Luna GK, Maier RV, Pavlin EG, Anardi D, Copass MK, Oreskovich MR. Incidence and effect of hypothermia in seriously injured patients. J Trauma. 1987;27(9):1014-1018.

  46. Rossaint R, Bouillon B, Cerny V, Coats TJ, Duranteau J, Fernández-Mondéjar E, et al. The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition. Crit Care. 2016;20:100.




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