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2018, Número 1

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Dermatología Cosmética, Médica y Quirúrgica 2018; 16 (1)


Opciones terapéuticas y preventivas no invasivas para el cáncer de piel no melanoma en pacientes pediátricos con xeroderma pigmentoso

Cheirif-Wolosky O, Palacios-López C

Idioma: Español
Referencias bibliográficas: 47
Paginas: 83-91
Archivo PDF: 163.32 Kb.


RESUMEN

El xeroderma pigmentoso es una enfermedad autosómica recesiva que se caracteriza porque presenta hipersensibilidad cutánea a los rayos ultravioleta (uv) con un riesgo elevado de presentar carcinoma basocelular, carcinoma espinocelular y melanoma desde la infancia. Existen múltiples opciones terapéuticas no invasivas para tratar a estos pacientes. Entre las opciones se encuentran los tratamientos tópicos, algunos de los cuales se han probado en pacientes con xeroderma pigmentoso. Algunas opciones son el imiquimod, el 5-fluorouracilo y el mebutato de ingenol. Para la quimioprevención se utilizan los retinoides sistémicos, y también son parte del tratamiento preventivo los protectores tópicos y sistémicos. Existen otros tratamientos innovadores como la fotoliasa y la endonucleasa t4n5. A continuación revisamos detalladamente cada uno de éstos.


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