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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2005, Número 4

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Rev Biomed 2005; 16 (4)


Activación de receptores dopaminérgicos por L-DOPA. De la acción terapéutica a las discinesias.

Florán-Garduño B, Rangel-Barajas C

Idioma: Español
Referencias bibliográficas: 65
Paginas: 273-280
Archivo PDF: 160.17 Kb.


RESUMEN

La L-DOPA continúa siendo el tratamiento de elección en la enfermedad de Parkinson. En el presente trabajo se presentan y discuten las bases que explican el principal mecanismo farmacológico y que permiten entender su éxito terapéutico: el reemplazo de dopamina. Asimismo, se cuestiona el porqué de la generación de sintomatología colateral durante el tratamiento por reemplazo, principalmente la discinesia, y se citan las propuestas que con base en hallazgos experimentales recientes contribuirían a entenderla. Mecanismos adicionales que incluyen la activación directa de receptores dopaminérgicos y la existencia de un sistema de neurotransmisión DOPAérgico pudieran contribuir al efecto y formar parte de la explicación. Creemos que un mejor entendimiento de la acción de la L-DOPA en la enfermedad de Parkinson contribuirá al desarrollo de nuevas expectativas farmacológicas para su tratamiento.


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