Ochoa-Anaya G, Aguirre-Ibarra CP, Franco-Cabrera M

Idioma: Español
Referencias bibliográficas: 50
Paginas: 220-225
Archivo PDF: 219.41 Kb.

RESUMEN

La lidocaína fue descrita como anestésico local. Es bien sabido que, como tal, actúa a través del bloqueo de canales de sodio de la membrana celular de neuronas periféricas sensitivas, impidiendo el movimiento de iones de sodio y potasio a través de los receptores del nervio y por lo tanto, la conducción nerviosa. Ésta es la propiedad más conocida; sin embargo, en los últimos años se han encontrado muchas nuevas propiedades más allá de las características clásicas descritas como anestésico local. El objetivo de este artículo fue realizar una revisión bibliográfica sobre todas las propiedades descritas para la lidocaína, y así poder presentar una recolección de todas en un solo lugar.

REFERENCIAS (EN ESTE ARTÍCULO)

1. Hernández-Bernal E. Lidocaína intravenosa como anestésico de base en neurocirugía. Rev Mex Anestesiol. 2011;34:133-137.

2. Michiardi M. Lidocaína. Su uso como antiarrítmico. Rev Arg Anest. 1995;53:41-49.

3. Hollmann MW, Durieux ME. Local anesthetics and the inflammatory response: a new therapeutic indication? Anesthesiology. 2000;93:858-875.

4. Van der Wal S, Steggers M, van Berkum B, Kox M, van der Laak J, van der Hoeven J, Vissers K, Scheffer J. Lidocaine increases the anti-inflammatory cytokine IL-10 following mechanical ventilation in healthy mice. Acta Anaesthesiol Scand. 2015;59:47-55.

5. Lauretti GR. Mechanisms of analgesia of intravenous lidocaine. Rev Bras Anestesiol. 2008;58:283-285.

6. McNulty MM, Edgerton GB, Shah RD, Hanck DA, Fozzard HA, Lipkind GM. Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels. J Physiol. 2007;581:741-755.

7. Hemmings HC Jr. Neuroprotection by Na+ channel blockade. J Neurosurg Anesthesiol. 2004;1:100-101.

8. De Klaver MJ, Weingart SG, Obrig T, Rich FG. Local anesthetic induced protection against lipopolisaccharide-induced injury in endothelial cells: the role of mitocondrial adenosine triophosphate-sensitive potassium channels. Anesth Analg. 2006;102:1108-1113.

9. Cooke ED, Bowcock SA, Lloyd MJ, Pilcher MF. Intravenous lidocaine in prevention of deep venous thrombosis after elective hip surgery. Lancet. 1997;2:797-799.

10. Wang HL, Xing YQ, Xu YX, Rong F, Lei WF, Zhang WH. The protective effect of lidocaine on septic rats via the inhibition of high mobility group box 1 expression and NF-κB activation. Mediators Inflamm 2013;2013:570370.

11. Tavares MF, Campos RM, Alvene AJ, Calvano LA. Systemic lidocaine for perioperative analgesia: a literature review. J Anest & Inten Care Med. 2015;1:555551. doi: 10.19080/JAICM.2015.01.555551

12. Lalenoh D, Bisri T, Yusuf I. Brain protection effect of lidocaine measured by interleukin-6 and phospholipase A2 concentration in epidural haematoma with moderate head injury patient. J Anesth Clin Res. 2014;5:1-8.

13. Gallos G, Jones DR, Nasr S, Emala CW, Lee HT. Local anesthetics reduce mortality and protect against renal and hepatic dysfunction in murine septic peritonitis. Anesthesiology. 2004;101:902-911.

14. Liu J, Zhang H, Qi Z, Zheng X. Lidocaine protects against renal and hepatic dysfunction in septic rats via downregulation of Toll-like receptor 4. Mol Med Rep. 2014;9:118-124.

15. Terwaki AS, Sharma S, Durieux ME, Thammishetti S, Brenin D, Tiouririne M. Perioperative lidocaine infusion reduces the incidence of post-mastectomy chronic pain a double-blind, placebo controlled randomized trial. Pain Physician. 2015;18:139-146.

16. Rimbäck G, Cassuto J, Wallin G, Westlander G. Inhibition of peritonitis by amide local anesthetics. Anesthesiology. 1988;69:881-886.

17. Cassuto J, Nellgard P, Stage L, Jonsson A. Amide local anesthetics reduce albumin extravasation in burn injuries. Anesthesiology. 1990;72:302-307.

18. Sinclair R, Eriksson AS, Gretzer C, Cassuto J, Thomsen P. Inhibitory effects of amide local anaesthetics on stimulus-induced human leukocyte metabolic activation, LTB4 release and IL-1 secretion in vitro. Acta Anaesthesiol Scand. 1993;37:159-165.

19. Perez R, Balboa MA, Balsinde J. Group IVA Phospholipase A2 derived lysophosphatidylcholine as a direct eat me signals for macrophages. Eicosanoid Research Division, Institute of Molecular Biology and genetics, Spanish Research Council and University of Valladolid school of Medicine. 47005 Valladolid, Spain. 13th Euroconference on Apoptosis. 2005;15:79.

20. Fischer LG, Conrad B, Krumm B, Hollmann MW, Durieux ME. Time-dependent attenuation by lidocaine of respiratory burst in human neutrophils primed with lysophosphatic acid. Anesth Analg. 2000;90:S405.

21. Jeon YT, Na H, Ryu H, Chung Y. Modulation of dendritic cell activation and subsequent th1 cell polarization by lidocaine. PLoS ONE. 2015;10(10):e0139845. doi: 10.1371/journal.pone.0139845.

22. Yardeni IZ, Beilin B, Maybrud E, Levinson Y, Bessler H. The effect of perioperative intravenous lidocaine on postoperative pain and immune function. Anesth Analg. 2009;109:1464-1469.

23. Mc Carthy GC, Megalla SA, Habib AS. Impact of intravenous lidocaine infusion on postoperative analgesia and recovery from surgery: a systematic review of controlled trials. Drugs. 2010;70:1149-1163.

24. Kaba A, Laurent SR, Detroz BJ, Sessler DI, Durieux ME, Lamy ML, et al. Intravenous lidocaine infusion facilitates acute rehabilitation after laparoscopic colectomy. Anesthesiology. 2007;106:11-18.

25. Thomasy SM, Pypendop BH, Ilkiw JE, Stanley SD. Pharmacokinetics of lidocaine and its active metabolite, monoethylglycinexylidide, after intravenous administration of lidocaine to awake and isoflurane-anesthetized cats. Am J Vet Res. 2005;66:1162-1166.

26. Kawamata M, Sugino S, Narimatsu E, Yamauchi M, Kiya T, Furuse S, et al. Effects of systemic administration of lidocaine and QX-314 on hyperexcitability of spinal dorsal horn neurons after incision in the rat. Pain. 2006;122:68-80.

27. Abelson KS, Hoglund AU. Intravenously administered lidocaine in therapeutic doses increases the intraspinal release of acetylcholine in rats. Neurosci Lett. 2002;317:93-96.

28. Biella G, Sotgiu ML. Central effects of systemic lidocaine mediated by glycine spinal receptors: an iontophoretic study in the rat spinal cord. Brain Res. 1993;603:201-206.

29. Nagy I, Woolf CJ. Lignocaine selectivity reduces C fibreevoked neuronal activity in rat spinal cord in vitro by decreasing N-methyl-D-aspartate and neurokinin receptor-mediated postsynaptic depolarizations; implications for the development of novel centrally acting analgesics. Pain. 1996;64:59-70.

30. Coda B, Bausch S, Haas M, Chavkin C. The hypothesis that antagonism of fentanyl analgesia by 2-chloroprocaine is mediated by direct action on opioid receptors. Reg Anesth. 1997;22:43-52.

31. Cohen SP, Mao J. Is the analgesic effect of systemic lidocaine mediated through opioid receptors? Acta Anaesthesiol Scand. 2003;47:910-911.

32. Southworth JL, McKuSick VA, Peirce EC, Rawson FL. Ventricular fibrillation precipitated by cardiac catheterization. Complete recovery of a patient after fortyfive minutes. J Am Med Assoc. 1950;143:717-720.

33. Josephson ME, Caracta AR, Lau SH, Gallager JJ, Damato AN. Effects of lidocaine on refractory periods in a man. Am Heart J. 1972;84:778-786.

34. Lee R, Nitta T, Schmid RA, Schuessler RB, Harris KM, Gay WAJ. Retrograde infusion of lidocaine or L-arginine before reperfusion reduces myocardial infarct size. Ann Thorac Surg 1998;65:1353-1359.

35. Sakuragi T, Ishino H, Dan K. Bactericidal activity of clinically used local anesthetics on Staphylococcus aureus. Reg Anesth. 1996;21:239-242.

36. Weinstein MP, Maderazo E, Tilton R, Maggini G, Quintiliani R. Further observations on the antimicrobial effects of local anesthetic agents. Curr Ther Res Clin Exp. 1975;17:369-374.

37. Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, Che J, et al. HMG-1 as a late mediator of endotoxin lethality in mice. Science. 1999;285:248-251.

38. Yang H, Ochani M, Li J, Qiang X, Tanovic M, Harris HE, et al. Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc Natl Acad Sci USA. 2004;101:296-301.

39. Nishina K, Mikawa K, Takao Y, Shiga M, Naekawa N, Obara H. Intravenous lidocaine attenuates acute lung injury induced by hydrochloric acid aspiration in rabbits. Anesthesiology. 1998;88:1300-1309.

40. Schmidt W, Schmidt H, Bauer H, Gebhard MM, Martin E. Influence of lidocaine on endotoxin-induced leukocyte-endothelial cell adhesion and macromolecular leakage in vivo. Anesthesiology. 1997;87:617-624.

41. Mikawa K, Nishina K, Tamada M, Takao Y, Maekawa N, Obara H. Aminoguanidine attenuates endotoxin-induced acute lung injury in rabbits. Crit Care Med. 1998;26:905-911.

42. Takao Y, Mikawa K, Nishina K, Maekawa N, Obara H. Lidocaine attenuates hyperoxic lung injury in rabbits. Acta Anaesthesiol Scand. 1996;40:318-325.

43. de Klaver MJ, Buckingham MG, Rich GF. Lidocaine attenuates cytokine-induced cell injury in endothelial and vascular smooth muscle cells. Anesth Analg. 2003;97:465-470.

44. Adamzik M, Groeben H, Farahani R, Lehmann N, Peters J. Intravenous lidocaine after tracheal intubation mitigates bronchoconstriction in patients with asthma. Anesth Analg. 2007;104:168-172.

45. Garutti I, Rancan L, Simon C, Cusati G, Sanchez PG, Moraga F, et al. Intravenous lidocaine decreases tumor necrosis factor alpha expression both locally and systemically in pigs undergoing lung resection surgery. Anesth Analg. 2014;119:815-828.

46. Chen K, Wei P, Zheng Q, Zhou J, Li J. Neuroprotective effects of intravenous lidocaine on early postoperative cognitive dysfunction in elderly patients following spine surgery. Med Sci Monit. 2015;21:1402-1407.

47. Sabroe I, Dower S, Whyte M. The role of toll-like receptors in the regulation of neutrophil migration, activation, and apoptosis. Clin Infect Dis. 2005;41:S421-426.

48. Nishida J, McCuskey RS, McDonnell D, Fox ES. Protective role of NO in hepatic microcirculatory dysfunction during endotoxemia. Am J Physiol. 1994;267:G1135-1141.

49. Alam M, Ricci D, Havey J, Rademaker A, Witherspoon J. Safety of peak serum lidocaine concentration after Mohs micrographic surgery: a prospective cohort study. J Am Acad Dermatol. 2010;63:87-92.

50. Tierney K, Murano T, Natal B. Lidocaine induced cardiac arrest in the emergency department: effectiveness of lipid therapy. J Emerg Med. 2016;50:47-50.