medigraphic.com
Federación Mexicana de Ginecología y Obstetricia, A.C.

2017, Número 08

<< Anterior Siguiente >>

Ginecol Obstet Mex 2017; 85 (08)


Repercusiones del índice de masa corporal masculina en los resultados de ICSI

Cancino-Villarreal P, González-Ortega C, Calull-Bagó A, Zúñiga-Sánchez P, Gutiérrez-Gutiérrez AM

Idioma: Español
Referencias bibliográficas: 45
Paginas: 531-540
Archivo PDF: 235.99 Kb.


RESUMEN

Objetivo: primario, determinar la influencia de la obesidad paterna en la tasa de embarazo, implantación, aborto y de recién nacido en casa en pacientes que reciben tratamientos de fertilización in vitro con ICSI. El objetivo secundario: determinar el efecto del índice de masa corporal del padre en la calidad seminal y embrionaria y en la tasa de fertilización.
Materiales y Métodos:: estudio retrospectivo, comparativo y observacional al que se incluyeron ciclos ICSI con transferencia embrionaria. Los ciclos se dividieron en 3 grupos según el IMC paterno: peso normal (18.5-24.99 kg/m2), sobrepeso (25-29.99 kg/m2) y obesidad (≥ 30 kg/m2).
Resultados: se estudiaron 365 ciclos consecutivos en fresco en los que se encontró un incremento significativo en la tasa de aborto en pacientes con obesidad comparados con el grupo sano (39.0 vs 12.9, p = 0.02), y una significativa disminución en la tasa de recién nacido en casa (38.6 vs 23.6; p = 0.04), además de menor tasa de embriones de excelente calidad, sin afectar la tasa de fertilización con ICSI.
Conclusiones: los resultados demuestran que aun cuando las tasas de embarazo e implantación son elevadas en pacientes con sobrepeso y obesidad con técnicas de alta complejidad o ICSI, el desarrollo embrionario, la tasa de aborto y tasa de recién nacido en casa se ven afectados por el incremento del IMC paterno.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Barrera A, Rodríguez A, Molina MA. Escenario actual de la obesidad en México. Rev Med Inst Mex Seguro Soc 2013;51:292-299.

  2. Calle EE, Rodríguez C, Walker-Thurmond K. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003;348:1625-1638.

  3. Hedley AA, Ogden CL, Johnson CL, et al. Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002. JAMA 2004;291:2847-2850.

  4. Meigs JB, Wilson PW, Fox CS, et al. Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. J Clin Endocrinol Metab 2006;91:2906-2912.

  5. Must A, Spadano J, Coakley EH, Field AE, Colditz G, Dietz WH. The disease burden associated with overweight and obesity. JAMA 1999;282:1523-1529.

  6. Bellver J. Obesity and poor reproductive outcome: female and male body weight matter. Fertil Steril 2013;99:1558- 1559.

  7. Bakos HW, Henshaw RC, Mitchell M, et al. Paternal body mass index is associated with decreased blastocyst development and reduced live birth rates following assisted reproductive technology. Fertil Steril 2011;95:1700-1704.

  8. Keltz J, Zapantis A, Jindal SK, et al. Overweight men: clinical pregnancy after ART is decreased in IVF but not in ICSI cycles. J Assist Reprod Genet 2010;27:39-544.

  9. Pasquali R, Pelusi C, Genghini S, et al. Obesity and reproductive disorders in women. Hum Reprod Update 2003;9:359-372.

  10. Hammoud AO, Wilde N, Gibson M, et al. Male obesity and alteration in sperm parameters. Fertil Steril 2008;90:2222- 2225.

  11. Hakonsen LB, Thulstrup AM, Aggerholm A, Olsen J, Bonde JP, et al. Does weight loss improve semen quality and reproductive hormons? Results from a cohort of severely obese men. Reprod Health 2011;8:24-31.

  12. Carlsen E, Givercman A, Keiding N, Skakkebak NE. Evidence of decreasing quality of semen during past 50 years. BMJ 1992;305:609-613.

  13. Anifandis G, Dafopoulus K, Messini CI, Polyzos N, Messinis IE. The BMI of men and not sperm parameters impact on embryo quality and the IVF outcome. Andrology 2013;1:85-89.

  14. Swan SH, Elkin EP, Fenster L. The question of declining sperm density revisited: an analysis of 101 studies published 1934-1996. Environ Health Perspect 2000;108:961- 966.

  15. Begg SJ, Vos T, Barker B, Stanley L, Lopez AD. Burden of disease and injury in Australia in the newmillennium: measuring health loss from diseases, injuries and risk factors. Med J Aust 2008;188:36-40.

  16. Guney AI, Javadova D, Kirac D, Ulucan K, Koc G, et al. Detection of Y chromosome microdeletions and ADN mitochondrial mutations in male infertility patients. Genet Mol Res 2012;11:1039-1048.

  17. Nguyen RH, Wilcox AJ, Skjaerven R, et al. Men’s body mass index and infertility. Hum Reprod 2007; 22:2488-2493.

  18. Ramlau-Hansen CH, Thulstrup AM, Nohr EA, et al. Subfecundity in overweight and obese couples. Hum Reprod 2007; 22:1634-1637.

  19. Hajshafiha M, Ghareaghaji R, Salemi S, Sadegh – Asadi N, Sadeghi-Bazargani H. Association of body mass index with some fertility markers among male parterns of infertile couples. Int J Gen Med 2013; 7:447-451.

  20. Hammoud AO, Gibson M, Peterson CM, et al. Impact of male obesity on infertility: a critical review of the current literature. Fertil Steril 2008; 90:897-904.

  21. Sallmen M, Sandler DP, Hoppin JA et al. Reduced Fertility among overweight and obese men. Epidemiology 2006; 17:520-523.

  22. MacDonald AA, Herbison GP, Showell M, Farquhar CM. The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysis. Hum Reprod Update 2010; 16:293-311.

  23. Teerds KJ, de Rooij DG, Keijer J. Functional relationship between obesity and male reproduction: from humans to animal models. Hum Reprod Update 2011;17: 667-683.

  24. Kort HI, Massay JB, Elsner CW, Mitchell-Leef D, Shapiro CB, et al. Impact of body mass index values on sperm quantity and quality. J Androl 2006; 27:450-452.

  25. Chavarro JE, Toth TL, Wright DL, Meeker JD, Hauser R. Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic. Fertil Steril 2010; 93:2222-2231.

  26. Colaci Daniela S, Afeiche M, Gaskins AJ, Wright DL, et al. Men's body mass index in relation to embryo quality and clinical outcomes in couples undergoing in vitro fertilization. Fertil Steril 2012; 98:1193-1199.

  27. Palermo GD, Neri QV, Rosenwaks Z. To ICSI or not to ICSI. Semin Reprod Med 2015;33:92-102.

  28. González OC, Cancino VP, Anaya T FJ, Pérez PE, Gutiérrez G AM. Impacto de la eclosión asistida con láser (técnica en cuartos) en pacientes con pobre pronóstico reproductivo. Ginecol Obstet Mex 2015; 83:670-679.

  29. Gutiérrez AM, González OC, Cancino VP, Tovar CG, Garza MA, Pérez-Peña E. Micromanipulación de gametos. En: Delgado UJ, Fernández del Castillo C. Ginecología y Reproducción Humana. Temas selectos. Colegio Mexicano de Especialistas en Ginecología y Obstetricia 2006;46:381-393.

  30. Braga DP, Halpern G, Figueria RC, Setti AS, Iaconelli A, et al. Food intake and social habits in male patients and its relationship to intracytoplasmatic sperm injection outcomes. Fertil Steril 2012;97:53-59.

  31. Petersen GL, Schmidt L, Pinborg A, Kamper-Jorgensen M. The influence of female and male body mass index on live births after assisted reproductive technology treatment: a nationwide register-based cohort study. Fertil Steril 2013;99:1654-1662.

  32. Kupka MS, Gnoth C, Buehler K, Dahncke W, Kruessel JS. Impact of female and male obesity on IVF/ICSI: results of 700, 000 ART – cycles in Germany. Gynecol. Endocrinol 2011;27:144-149.

  33. Moragianni VA, Jones SML, Ryley DA, The effect of body mass index on the outcomes of first assisted reproductive technology cycles. Fertil Steril 2012;98:102-108.

  34. Hinz S, Rais-Bahrami S, Kempkensteffen C, Weiske WH, Miller K, Magheli A. Effect of obesity on hormone levels, antisperm antibodies, and fertility after vasectomy reversal. Urology 2010; 76:851-856.

  35. Hwang K, Walters RC, Lipshultz LI. Contemporary concepts in the evaluation and management of male infertility. Nat Rev Urol 2011; 8:86-94.

  36. Twigg J, Fulton N, Gomez E, Irvine DS, Aitken RJ. Analysis of the impact of intracellular reactive oxygen species generation on the structural and functional integrity of human spermatozoa: lipid peroxidation, DNA fragmentation and effectiveness of antioxidants. Hum Reprod 1998; 13:1429-1436.

  37. Kumar K, Deka D, Singh A, Mitra DK, Vanitha BR, Dada R. Predictive value of DNA integrity analysis in idiopathic recurrent pregnancy loss following spontaneous conception. J Assist Reprod Genet 2012; 9801-9803.

  38. Bakos HW, Thompson JG, Feil D, Lane M. Sperm DNA damage is associated with assisted reproductive technology pregnancy. Int J Androl 2008; 31:518-526.

  39. Gallagher JE, Vine MF, Schramm MM, Lewtas J, George MH, Hulka BS et al. 32P-postlabeling analysis of DNA adducts in human sperm cells from smokers and nonsmokers. Cancer Epidemiol Biomarkers Prev 1993;2:581-585.

  40. Brahem S, Mehdi M, Landolsi H, Mougou S, Elghezal H, Saad A. Semen parameters and sperm DNA fragmentation as causes of recurrent pregnancy loss. Urology 2011;78:792-796.

  41. Thomson LK, Zieschang JA, Clark AM. Oxidative deoxyribonucleic acid damage in sperm has a negative impact on clinical pregnancy rate in intrauterine insemination but not intracytoplasmic sperm injection cycles. Fertil Steril 2011;96:843-847.

  42. Thomsen L, Humaidan P, Bungum L, Bungum M. The impact of male overweight on semen quality and outcome of assisted reproduction. Asian Journal of Andrology 2014; 16:749-754.

  43. Aitken RJ, Jones KT, Robertson SA. Reactive oxygen species and sperm function–in sickness and in health. J Androl 2012;33:1096-1106.

  44. 44. Lewis SE, Boyle PM, McKinney KA, Young IS, Thompson W. Total antioxidant capacity of seminal plasma is different in fertile and in fertile men. Fertil Steril 1995;64:868-870.

  45. Lewis SE. Should sperm DNA fragmentation testing be included in the male infertility work up? RBM online 2015;31:134-137.




2020     |     www.medigraphic.com