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2013, Número 3

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Rev Educ Bioquimica 2013; 32 (3)


La ruta de señalización de la cinasa de proteínas tipo a dependiente del AMPc en Saccharomyces cerevisiae

Pérez-Landero S, Nieto-Sotelo J

Idioma: Español
Referencias bibliográficas: 35
Paginas: 95-105
Archivo PDF: 334.33 Kb.


RESUMEN

La fosforilación reversible de las proteínas regula una infinidad de procesos celulares. La cinasa de proteínas dependiente del AMP cíclico (PKA) está presente en todos los eucariontes (protozoarios, animales, algas y hongos) a excepción de las plantas terrestres y su estudio ha revelado mecanismos importantes para la señalización celular. Aquí se describen los componentes de la cascada de señalización de la PKA en Saccharomyces cerevisiae, la compartamentalización de las subunidades regulatorias, así como los mecanismos de regulación de la respuesta al estrés, la estimulación del crecimiento filamentoso y la retro-regulación de la actividad de la PKA. El análisis genético de los componentes de la vía PKA en S. cerevisiae ha arrojado información muy detallada acerca de su evolución, de sus relaciones estructura-función y de su operación mediante el desarrollo de modelos matemáticos y computacionales.


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