Romero GMB, Cruz OH, Luise HM, Krueger GRF, Gathof B, Durán PMA, Rojo J

Idioma: Español
Referencias bibliográficas: 24
Paginas: 124-129
Archivo PDF: 126.80 Kb.

RESUMEN

El linfoma de Hodgkin constituye un grupo heterogéneo de enfermedades que difieren en el curso clínico, aspecto morfológico, inmunofenotipo, y por su relación con los virus herpes humanos 4 y 6. En el presente trabajo investigamos la frecuencia y localización de ambos virus en el linfoma de Hodgkin en 84 pacientes y comparamos los resultados con otros trabajos efectuados en otras instituciones de salud de la Ciudad de México. El virus de Epstein-Barr (VEB) se encontró presente en 54 casos (64.2%), en células de Hodgkin y de Reed-Sternberg y ocasionalmente en linfocitos e histiocitos. El HHV-6 estuvo presente en 14 casos (16.6%) en linfocitos e histiocitos y ocasionalmente en células de Hodgkin y de Reed-Sternberg. Ambos virus estuvieron presentes en 10 casos (11.9%), en seis de linfoma de Hodgkin celularidad mixta y en cuatro de linfoma de Hodgkin esclerosis nodular. Además se efectuaron marcadores de proliferación celular como el Ki 67 (Mib 1) y de apoptosis p53; el primero se observó en células de Hodgkin y de Reed-Sternberg en 78 casos (92.8%) y el segundo en 71 casos (84.5%), en histiocitos y linfocitos y ocasionalmente en células neoplásicas.

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