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2017, Número 3

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Rev Med Inst Mex Seguro Soc 2017; 55 (3)


¿Qué tan segura es la hormona de crecimiento humana recombinante?

Calzada-León R

Idioma: Español
Referencias bibliográficas: 112
Paginas: 341-352
Archivo PDF: 354.71 Kb.


RESUMEN

Se revisan diferentes aspectos relacionados con la seguridad del uso de la hormona de crecimiento humana recombinante en niños, tales como su tipificación como un medicamento biosintético, las fases que es necesario realizar en nuestro país para verificar su seguridad (obtención, purificación, etapa preclínica, estudios clínicos experimentales y finalmente estudios clínicos observacionales) y se expone la evidencia que existe en relación con la asociación de hipertensión intracraneana, eventos musculares, escoliosis, deslizamiento de la cabeza femoral, apnea obstructiva del sueño, pancreatitis, alteraciones en cortisol, modificaciones de las hormonas tiroideas, enfermedad cardiovascular, riesgo metabólico, mortalidad y cáncer, eventos adversos no relacionados con su uso, y finalmente dosificación y seguridad.


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