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Federación Mexicana de Ginecología y Obstetricia, A.C.

2016, Número 03

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Ginecol Obstet Mex 2016; 84 (03)


Concentraciones séricas maternas de 25-hidroxivitamina D en el primer trimestre y resultados adversos gestacionales

Álvarez-Silvares E, Vilouta-Romero M, Borrajo-Hernández E, Morales-Serrano ML, Alves-Pérez MT

Idioma: Español
Referencias bibliográficas: 48
Paginas: 150-163
Archivo PDF: 365.09 Kb.


RESUMEN

Antecedentes: la deficiencia de vitamina D (25(OH)D) se relaciona con diversas afecciones de la gestación y del recién nacido. La fisiopatología de esta relación aún no se conoce del todo.
Objetivo: establecer si las concentraciones séricas de vitamina D determinadas al inicio de la gestación se relacionan con: diabetes gestacional, cuadros hipertensivos del embarazo, prematuridad y alteraciones del crecimiento fetal.
Material y Método: estudio de cohortes, prospectivo, efectuado en gestantes de bajo riesgo obstétrico, seleccionadas al azar en Ourense, España (latitud 42º 20´N). Se determinó la concentración de la 25-hidroxivitamina D entre las semanas 8 y 14. Se estudió la relación entre los valores de la 25-hidroxivitamina D y la diabetes gestacional, preeclampsia, prematuridad, retraso del crecimiento intrauterino y fetos pequeños para la edad gestacional. El análisis estadístico se efectuó con los programas SPSS 15.0 y Epidat 3.1.
Resultados: se estudiaron 370 pacientes, de ellas 96.8% tuvieron hipovitaminosis; de éstas, 34.6% con deficiencias severas. Al ajustar las variables maternas y estacionales no se encontró asociación entre las concentraciones de vitamina D al inicio de la gestación y los resultados adversos estudiados.
Conclusión: no se encontró asociación significativa entre el déficit de vitamina D determinado al inicio de la gestación y los padecimientos seleccionados.


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