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2016, Número 2

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RCAN 2016; 26 (2)


Sobre el comportamiento de biomarcadores de la arteriosclerosis en la hipertensión arterial

García SN, León ÁJL

Idioma: Español
Referencias bibliográficas: 85
Paginas: 252-274
Archivo PDF: 470.51 Kb.


RESUMEN

Justificación: La enfermedad cardiovascular (ECV) es una de las primeras causas globales de mortalidad. La formación de placas ateroscleróticas que ocluyen progresivamente la luz arterial subyace en la génesis de la ECV. La hipertensión arterial (HTA) es uno de los principales factores de riesgo de desarrollo de ECV. Se han descrito novedosos biomarcadores de aterosclerosis para detectar aquellos sujetos no identificados necesariamente mediante los usados tradicionalmente. Objetivo: Evaluar el comportamiento de biomarcadores novedosos de aterosclerosis en la HTA no complicada y sin afectación de órganos diana. Diseño de estudio: Analítico, transversal. Serie de estudio: Cien pacientes hipertensos (Hombres: 56.0%; Edades ≥ 60 años: 22.0%; Estadio I de progresión: 78.0%; Evolución ‹ 5 años: 49.0%) sin afectación de órganos diana que acudieron consecutivamente a la Consulta especializada del Servicio de Medicina Interna, Hospital “Hermanos Ameijeiras” (La Habana, Cuba). Material y método: Se examinaron las asociaciones entre el grosor de la íntima de la carótida media (GIM), la presencia de albuminuria, y las concentraciones séricas de hemoglobina glicosilada (HbA1c), troponina T (TnT), péptido natrurético (BNP), proteína C reactiva de alta sensibilidad (hsPCR), fibrinógeno y Cistatina C (Cyst). Resultados: Un GIM aumentado se asoció con Creatinina sérica elevada y filtrado glomerular disminuido. La albuminuria fue prevalente entre los hipertensos. Conclusiones: La Creatinina sérica puede señalar al hipertenso con ateroesclerosis de la vasculatura renal.


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