2015, Número 1
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Arch Neurocien 2015; 20 (1)
Efectos nocivos del consumo prolongado de alcohol sobre el sistema nervioso central
Cristóvão-Calado JM, Broche-Pérez Y, Rodríguez-Méndez L
Idioma: Español
Referencias bibliográficas: 53
Paginas: 79-85
Archivo PDF: 87.86 Kb.
RESUMEN
El alcohol constituye una droga de elevado consumo a escala global. En el caso particular de los seres humanos,
existen numerosas consecuencias asociadas a su consumo excesivo que varían de acuerdo al sexo, peso corporal,
velocidad de su ingestión, tamaño de dosis, entre otros factores. En la actualidad no existen dudas sobre el impacto
negativo que tiene el alcohol sobre el sistema nervioso central (SNC) existiendo varias hipótesis sobre la acción
específica de esta sustancia sobre el funcionamiento cerebral.
Objetivo: se realizó una revisión del estado actual de
la literatura científica en relación a los efectos del alcohol sobre el SNC y consecuencias neuropsicológicas asociadas
a su consumo.
Resultados: existen varios modelos que intentan explicar los mecanismos de acción del alcohol sobre
el cerebro destacándose los modelos basados en las características individuales de alcohólicos y modelos basados
en la vulnerabilidad de los sistemas cerebrales. Dentro de las áreas que resultan más afectadas por esta sustancia
se encuentran las estructuras prefrontales y el cerebelo.
Conclusiones: existe evidencia empírica sólida que demuestra
los efectos estructurales y funcionales nocivos que provoca el alcohol sobre el sistema nervioso central,
fundamentalmente a causa de su consumo sistemático.
REFERENCIAS (EN ESTE ARTÍCULO)
Zahr NM, KL Kaufman, CG Harper, Clinical and pathological features of alcohol-related brain damage. Nat Rev Neurol 2011;7:284-94.
WHO, Neuroscience of psychoactive substance use and dependence2005, Washington, D.C: World Health Organization.
Brust JCM. Ethanol and Cognition: Indirect Effects, Neurotoxicity and Neuroprotection: a Review Int. J Environ Res Public Health 2010;7:1540-57.
Oscar-Berman, MK Marinkovic. Alcoholism and the Brain: An Overview Alcohol Research & Health 2003;27(2):125-33.
Oscar-Berman M, Marinkovic K. Alcohol: ef fects on neurobehavioral functions and the brain. Neuropsycholy Review 2007;17:239-57.
luhar RB. Brain volumes and neuropsychological performance are related to current smoking and alcoholism histor y. Neuropsychiatric disease and treatment 2013;9:1767-84.
Schulte T. Corpus callosal microstructural integrity influences interhemispheric processing: adiffusion tensor imaging study. Cerebral Cortex 2005;15(9):1384-92.
Sullivan EV. Longitudinal changes in cognition, gait, and balance in abstinent and relapsed alcoholic men: Relationships to changes in brain structure. Neuropsychology 2000;14(2):178-88.
Laakso MP. A volumetric MRI study of the hippocampus in type1 and 2 alcoholism. Behavioral Brain Research 2000;109(2):177-86.
Nolen-Hoeksema S, L. Hilt. Possible contributors to the gender differences in alcohol use and problems. J General Psychology 2006;133(4):357-74.
Wuethrich B. Does alcohol damage female brains more? Science 2001; 291(5511): 2077-79.
Yonker JE. Sex differences in spatial visualization and episodic memory as a function of alcohol consumption. Alcohol and Alcoholism 2005; 40(3):201-7.
Kalant H. Pharmacological interactions of aging and alcohol. Alcohol Problems and Aging 1998(33):99-116.
Lishman WA. Alcohol and the brain. British J Psychiatry 1990; 156: 635-44.
Oscar-Berman M, HE Schendan. Asymmetries of brain function in alcoholism: Relationship to aging, in Neurobehavior of Language and Cognition: Studies of Normal Aging and Brain Damage, L.T. Connor and L.K. Obler, Editors. 2000, Kluwer Academic Publishers: New York. 213-40.
Moselhy HF, G Georgiou, A Kahn. Frontal lobe changes in alcoholism: A review of the literature. Alcohol and Alcoholism 2001; 36: 357-68.
Adams KM, Gilman S, Johnson-Greene D, Significance of family histor y status in relation to neuropsychological test performance and cerebral glucose metabolism studied with positron emission tomography in older alcoholic patients. Alcoholism Clini Exp Research 1998. 22(1):105-10.
Kornreich C, P Philippot, ML Foisy. Impaired emotional facial expression recognition is associated with interpersonal problems in alcoholism. Alcohol and Alcoholism 2002; 37:394- 400.
Monnot M. Neurological basis of deficits in affective prosody comprehension among alcoholics and fetal alcohol-exposed adults. J Neuropsych Clin Neuroscien 2002;14:321-8.
Ratti MT. Chronic alcoholism and the frontal lobe: Which executive functions are impaired? Ac Neurol Scandinavica 2002; 105(4):276-81.
Oscar-Berman M. Comparisons of Korsakoff and non-Korsakoff alcoholics on neuropsychological tests of prefrontal brain functioning. Alcoholism. Clin Exp Resear 2004;28(4):667-75.
Pfefferbaum A. Frontal lobe volume loss obser ved with magnetic resonance imaging in older chronic alcoholics. Alcoholism. Clin Exper Resear 1997;21(3):521-9.
Gansler DA. Hypoperfusion of inferior frontal brain regions in abstinent alcoholics: a pilot SPECT study. J Studies on Alcohol 2000;61(1):32-7.
Dirksen CL. Patterns of prefrontal dysfunction in alcoholics with or without Korsakof f’s syndrome, patients with Parkinson’s disease,and patients with rupture and repair of the anterior communicating artery. Neuropsych Dis Treat 2006; 23(3):327-39.
Harper CG, I Matsumoto. Ethanol and brain damage. Current Opinion in Pharmacology 2005;5:73-8.
Harper CG. The neuropathology of alcohol-specific brain damage, or does alcohol damage the brain? J Neuropathol Experimen Neurol 1998; 57(2):101–10.
Lichter DG, JL Cummings. Frontal-sub cortical circuits in psychiatric and neurological disorders 2001, New York: The Guilford Press.
Lezak MD. Neuropsychological assessment 3ed 1995, New York: Oxford University Press.
Tirapu-Ustárroz J, JM Muñoz-Céspedes, C. Pelegrín-Valero, Funciones ejecutivas: necesidad de una integración conceptual. Rev Neurol 2002;34(7):673-85.
dos-Santos M. Desempeño neuropsicológico y características sociodemográficas en pacientes alcohólicos en tratamiento. Adicciones 2014;26(3):221-9.
Mota N. Binge drinking trajectory and neuropsychological functioning among university students: a longitudinal study. Drug and Alcohol Dependence 2013;133:108-14.
Clark US. Alcoholism and judgments of affective stimuli. Neuropsychol 2007;21(3):346-62.
Monnot M, et al. Neurological basis of deficits in affective prosody comprehension among alcoholics and fetal alcoholexposed adults. J Neuropsych Clin Neurosc 2002;14(3):321-8.
Stevens MC, RF Kaplan, VM Hesselbrock. Executive-cognitive functioning in the development of antisocial personality disorder. Addictive Behaviors 2003;28(2):285-300.
Hesselbrock VM, MN Hesselbrock, JR Stabenau. Alcoholism in men patients subtyped by family history and antisocial personality. J Studies on Alcohol 1985;46(1):59-64.
Regier DA. Comorbidity of mental disorders with alcohol and other drug abuse. Results from the epidemiologic catchment area (ECA) study. J Am Med Assoc 1990;264(19):2511-8.
Amaral DG. The amygdala: Is it an essential component of the neural network for social cognition? Neuropsychologia 2003; 41(4):517-22.
LeDoux JE. The emotional brain, fear, and the amygdala. Cell and Molecular Neurobiology 2003;23(4-5):727-38.
Rolls ET. Precis of the brain and emotion. Behavioral and Brain Sciences 2000;23:177-234.
Richardson MP, BA Strange, RJ Dolan. Encoding of emotional memories depends on amygdala and hippocampus and their interactions. Nat Neurosc 2004;7(3):278-85.
LaBar KS, R. Cabeza. Cognitive neuroscience of emotional memory. Nat Reviews: Neurosc 2006;7(1):54-64.
Herrera DG. Selective impairment of hippocampal neurogenesis by chronical coholism: Protective ef fects of an antioxidant. Proceed National Acad Sc 2003;100(3):7919-24.
Harding AJ. Chronic alcohol consumption does not cause hippocampal neuron loss in humans. Hippocampus 1997;70(10):78-87.
Nagel BJ. Hippocampal volume among adolescents with alcohol use disorders without psychiatric comorbidity. Psychiatry Research. Neuroimaging 2005;193(3):181-90.
White AM, DB Matthews, PJ Best. Ethanol, memory, and hippocampal function: a review of recent findings. Hippocampus 2000;10:88-93.
Oscar-Berman M. Impairments of brain and behavior.The neurologicale ffects of alcohol. Alcohol Health and Research World, 1997. 21(1):65-75.
Schmahmann JD. The role of the cerebellum in affect and psychosis. J Neuroling 2000;13:189-214.
Pentney RJ. The total numbers of cerebellar granule neurons in young and aged Fischer 344 and Wistar-Kyotorats do not changeas a result of lengthy ethanol treatment. Cerebellum 2002;1(1):79-89.
Cardoso CO. The impact of frontal and cerebellar lesions on decision making: evidence from the Iowa Gambling Task. Frontiers in Neuroscience 2014;8(61).
Stoodley CJ, JD Schmahmann. Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies. Neuroimage 2009;44: 489-501.
Schmahmann JD, EE Smith, FS Eichler. Cerebral white matter: neuroanatomy, clinical neurology,and neurobehavioral correlates. Ann NY Acad Sci 2008;1142:266-309.
Grimaldi G, M. Manto, Topography of cerebellar deûcits in humans. Cerebellum 2012;11:336-51.
Chanraud S. Brain morphometry and cognitive performance in detoxified alcohol-dependents with preserved psychosocial functioning. Neuropsychopharmacology 2007;32(2):429-38.