2016, Número 1
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Rev Acta Médica 2016; 17 (1)
La desnutrición y la inflamación—'candela al jarro': La inflamación como una respuesta fisiológica adaptiva o autodestrucción?
Jensen GL
Idioma: Ingles.
Referencias bibliográficas: 65
Paginas:
Archivo PDF: 185.42 Kb.
RESUMEN
Se presenta un resumen de mi Conferencia de Rhoads 2014 que explora nuestro
progreso en la comprensión de la compleja interacción de la desnutrición y la
inflamación. Se proporciona una perspectiva histórica que pone de relieve las
contribuciones de algunos de los principales pioneros en el campo de la evaluación
nutricional. Los avances en la agricultura, la educación, la salud pública, la asistencia
sanitaria, y los niveles de vida han afectado a la configuración tradicional de la
desnutrición. Las condiciones crónicas de la enfermedad, cirugía y lesiones que están
asociadas con la atención sanitaria moderna son cada vez más la configuración
prevalentes de la desnutrición. Una consecuencia ha sido la creciente evaluación de las
contribuciones de la inflamación a la desnutrición en esta situación clínica. Este
reconocimiento ha impulsado una nueva mirada a cómo definimos y pensamos en los
síndromes de mala nutrición. Está incluido un componente inflamatorio en las
definiciones propuestas en el informe de consenso de la reciente Academia de
Nutrición y Dietética y la Sociedad Americana de Nutrición Parenteral y Enteral que
también describe las características recomendadas para la identificación y
documentación de la desnutrición. Actualmente se está trabajando para evaluar la
viabilidad y la validez de este enfoque. Los recientes avances en la investigación ponen
de manifiesto el profundo impacto de la erosión mediada por la inflamación de la masa
muscular en los resultados clínicos. La investigación para identificar mejores
marcadores biológicos de la inflamación y la desnutrición debe ser una de las
principales prioridades. Los nuevos enfoques "ómicos" son una vía especialmente
prometedora de investigación de los biomarcadores. La inflamación puede ser una
buena cosa; vamos a tratar de que lo siga siendo.
(JPEN J Parenter Enteral
Nutr. 2015;39:56-62)
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