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Órgano Oficial de la Asociación Dental Mexicana

2016, Número 5

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Rev ADM 2016; 73 (5)


Posible papel de Porphyromonas gingivalis en el desarrollo de la artritis reumatoide

Martínez RJI, Xibillé FDX, Montiel HJL

Idioma: Español
Referencias bibliográficas: 71
Paginas: 235-240
Archivo PDF: 257.38 Kb.


RESUMEN

Varios estudios han sugerido una asociación entre la periodontitis severa, la prevalencia de la bacteria Porphyromonas gingivalis y el desarrollo de artritis reumatoide. Como fundamento de esta relación, se ha observado que esta bacteria secreta una enzima, peptidil-arginina deiminasa, que es capaz de citrulinar proteínas del hospedero y así favorecer una respuesta autoinmune. Sin embargo, debido a la heterogeneidad de diseños experimentales, selección de pacientes y valoración de los desenlaces, los resultados no han mostrado la reproducibilidad deseada. Asimismo, observaciones recientes apuntan a que la actividad enzimática podría ser generada por otras especies bacterianas, lo que hace más compleja su relación. Sin embargo, por otro lado, algunos estudios sugieren que el tratamiento periodontal puede limitar el desarrollo de la artritis reumatoide.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Yavuzyilmaz E et al. Clinical and immunological characteristics of patients with rheumatoid arthritis and periodontal disease. J Nihon Univ Sch Dent. 1992; 34 (2): 89-95.

  2. Greenwald RA, Kirkwood K. Adult periodontitis as a model for rheumatoid arthritis (with emphasis on treatment strategies). J Rheumatol. 1999; 26: 1650-1653.

  3. Mercado F et al. Is there a relationship between rheumatoid arthritis and periodontal disease? J Clin Periodontol. 2000; 27: 267-272.

  4. Mercado FB et al. Relationship between rheumatoid arthritis and periodontitis. J Periodontol. 2001; 72: 779-787.

  5. Havemose-Poulsen A et al. Periodontal and hematological characteristics associated with aggressive periodontitis, juvenile idiopathic arthritis, and rheumatoid arthritis. J Periodontol. 2006; 77: 280-288.

  6. de Pablo P, Dietrich T, McAlindon TE. Association of periodontal disease and tooth loss with rheumatoid arthritis in the US population. J Rheumatol. 2008; 35: 70-76.

  7. Pers JO et al. Anti-TNF-alpha immunotherapy is associated with increased gingival inflammation without clinical attachment loss in subjects with rheumatoid arthritis. J Periodontol. 2008; 79: 1645-1651.

  8. Pischon N et al. Association among rheumatoid arthritis, oral hygiene, and periodontitis. J Periodontol. 2008; 79: 979-986.

  9. Dissick A et al. Association of periodontitis with rheumatoid arthritis: a pilot study. J Periodontol. 2010; 81: 223-230.

  10. Mirrielees J et al. Rheumatoid arthritis and salivary biomarkers of periodontal disease. J Clin Periodontol. 2010; 37: 1068-1074.

  11. Ziebolz D et al. Clinical periodontal and microbiologic parameters in patients with rheumatoid arthritis. J Periodontol. 2011; 82: 1424-1432.

  12. Ranade SB, Doiphode S. Is there a relationship between periodontitis and rheumatoid arthritis? J Indian Soc Periodontol. 2012; 16: 22-27.

  13. Chen HH et al. Association between a history of periodontitis and the risk of rheumatoid arthritis: a nationwide, population-based, case-control study. Ann Rheum Dis. 2013; 72: 1206-1211.

  14. Ishi-Ede P et al. Periodontal condition in patients with rheumatoid arthritis. Braz Oral Res. 2008; 22: 72-77.

  15. Demmer RT et al. Periodontal disease, tooth loss and incident rheumatoid arthritis: results from the First National Health and Nutrition Examination Survey and its epidemiological follow-up study. J Clin Periodontol. 2011; 38: 998-1006.

  16. Bartold PM, Marshall RI, Haynes DR. Periodontitis and rheumatoid arthritis: a review. J Periodontol. 2005; 76 (11 Suppl): 2066-2074.

  17. Havemose-Poulsen A et al. Cytokine profiles in peripheral blood and whole blood cell cultures associated with aggressive periodontitis, juvenile idiopathic arthritis, and rheumatoid arthritis. J Periodontol. 2005; 76: 2276-2285.

  18. Bozkurt FY et al. Anti-inflammatory cytokines in gingival crevicular fluid in patients with periodontitis and rheumatoid arthritis: a preliminary report. Cytokine. 2006; 35: 180-185.

  19. Kobayashi T et al. The interleukin-1 and Fcgamma receptor gene polymorphisms in Japanese patients with rheumatoid arthritis and periodontitis. J Periodontol. 2007; 78: 2311-2318.

  20. Nilsson M, Kopp S. Gingivitis and periodontitis are related to repeated high levels of circulating tumor necrosis factor-alpha in patients with rheumatoid arthritis. J Periodontol. 2008; 79: 1689-1696.

  21. Kobayashi T et al. Serum cytokine and periodontal profiles in relation to disease activity of rheumatoid arthritis in Japanese adults. J Periodontol. 2010; 81: 650-657.

  22. Mayer Y, Balbir-Gurman A, Machtei EE. Anti-tumor necrosis factor-alpha therapy and periodontal parameters in patients with rheumatoid arthritis. J Periodontol. 2009; 80: 1414-1420.

  23. Ustun K et al. Host modulation in rheumatoid arthritis patients with TNF blockers significantly decreases biochemical parameters in periodontitis. Inflammation. 2013; 36: 1171-1177.

  24. Kobayashi T et al. Periodontal and serum protein profiles in patients with rheumatoid arthritis treated with tumor necrosis factor inhibitor adalimumab. J Periodontol. 2014; 85: 1480-1488.

  25. Gumus P et al. Gingival crevicular fluid, serum levels of receptor activator of nuclear factor-kappa B ligand, osteoprotegerin, and interleukin-17 in patients with rheumatoid arthritis and osteoporosis and with periodontal disease. J Periodontol. 2013; 84: 1627-1637.

  26. Gumus P et al. Gingival crevicular fluid and serum levels of APRIL, BAFF and TNF-alpha in rheumatoid arthritis and osteoporosis patients with periodontal disease. Arch Oral Biol. 2013; 58: 1302-1308.

  27. Hao L et al. Deficiency of cathepsin K prevents inflammation and bone erosion in rheumatoid arthritis and periodontitis and reveals its shared osteoimmune role. FEBS Lett. 2015; 589: 1331-1339.

  28. Scardina GA, Messina P. Microvascular periodontal alterations: a possible relationship between periodontitis and rheumatoid arthritis. Clin Hemorheol Microcirc. 2007; 37: 229-235.

  29. Sezer U et al. Effect of chronic periodontitis on oxidative status in patients with rheumatoid arthritis. J Periodontol. 2013; 84: 785-792.

  30. Moen K et al. Synovial inflammation in active rheumatoid arthritis and psoriatic arthritis facilitates trapping of a variety of oral bacterial DNAs. Clin Exp Rheumatol. 2006; 24: 656-663.

  31. Martinez-Martinez RE et al. Detection of periodontal bacterial DNA in serum and synovial fluid in refractory rheumatoid arthritis patients. J Clin Periodontol. 2009; 36: 1004-1010.

  32. Ogrendik M et al. Serum antibodies to oral anaerobic bacteria in patients with rheumatoid arthritis. Med Gen Med. 2005; 7: 2.

  33. Mikuls TR et al. Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis. Int Immunopharmacol. 2009; 9: 38-42.

  34. Okada M et al. Antibody responses to periodontopathic bacteria in relation to rheumatoid arthritis in Japanese adults. J Periodontol. 2011; 82: 1433-1441.

  35. de Smit M et al. Periodontitis in established rheumatoid arthritis patients: a cross-sectional clinical, microbiological and serological study. Arthritis Res Ther. 2012; 14: R222.

  36. Mikuls TR et al. Porphyromonas gingivalis and disease-related autoantibodies in individuals at increased risk of rheumatoid arthritis. Arthritis Rheum. 2012; 64: 3522-3530.

  37. Mikuls TR et al. Periodontitis and Porphyromonas gingivalis in patients with rheumatoid arthritis. Arthritis Rheumatol. 2014; 66: 1090-1100.

  38. Kharlamova N et al. Antibodies to Porphyromonas gingivalis indicate interaction between oral infection, smoking and risk genes in rheumatoid arthritis etiology. Arthritis Rheumatol. 2015; 68: 604-608.

  39. Lee JY et al. Association between anti-Porphyromonas gingivalis or anti-alpha-enolase antibody and severity of periodontitis or rheumatoid arthritis (RA) disease activity in RA. BMC Musculoskelet Disord. 2015; 16: 190.

  40. Scher JU et al. Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis. Arthritis Rheum. 2012; 64 (10): 3083-3094.

  41. Konig MF et al. Defining the role of Porphyromonas gingivalis peptidylarginine deiminase (PPAD) in rheumatoid arthritis through the study of PPAD biology. Ann Rheum Dis. 2015; 74: 2054-2061.

  42. de Smit M et al. Antibodies against Porphyromonas gingivalis in seropositive arthralgia patients do not predict development of rheumatoid arthritis. Ann Rheum Dis. 2014; 73: 1277-1279.

  43. Fisher BA et al. Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European nested case-control study. BMC Musculoskelet Disord. 2015; 16: 331.

  44. Courvoisier N et al. Prognostic factors of 10-year radiographic outcome in early rheumatoid arthritis: a prospective study. Arthritis Res Ther. 2008; 10: R106.

  45. Forslind K et al. Prediction of radiological outcome in early rheumatoid arthritis in clinical practice: role of antibodies to citrullinated peptides (anti-CCP). Ann Rheum Dis. 2004; 63: 1090-1095.

  46. Gabarrini G et al. The peptidylarginine deiminase gene is a conserved feature of Porphyromonas gingivalis. Sci Rep. 2015; 5: 13936.

  47. Fujimura S, Hirai K, Shibata Y. Dipeptidyl peptidase with strict substrate specificity of an anaerobic periodontopathogen Porphyromonas gingivalis. FEMS Microbiol Lett. 2002; 209: 127-131.

  48. Shirai H, Blundell TL, Mizuguchi K. A novel superfamily of enzymes that catalyze the modification of guanidino groups. Trends Biochem Sci. 2001; 26: 465-468.

  49. McGraw WT et al. Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminase. Infect Immun. 1999; 67: 3248-3256.

  50. Cugini C et al. Arginine deiminase inhibits Porphyromonas gingivalis surface attachment. Microbiology. 2013; 159: 275-285.

  51. Bielecka E et al. Peptidyl arginine deiminase from Porphyromonas gingivalis abolishes anaphylatoxin C5a activity. J Biol Chem. 2014; 289: 32481-32487.

  52. Santegoets KC et al. Impaired Porphyromonas gingivalis induced TNF alpha production by dendritic cells typifies patients with rheumatoid arthritis. Arthritis Rheumatol. 2016; 68: 795-804.

  53. Goulas T et al. Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase. Sci Rep. 2015; 5: 11969.

  54. Montgomery AB et al. Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis. Ann Rheum Dis. 2016; 75 (6): 1255-1261.

  55. Romero V et al. Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis. Sci Transl Med. 2013; 5 (209): 209ra150.

  56. Lundberg K et al. Periodontitis in RA-the citrullinated enolase connection. Nat Rev Rheumatol. 2010; 6: 727-730.

  57. Sandhya P et al. Does the buck stop with the bugs?: an overview of microbial dysbiosis in rheumatoid arthritis. Int J Rheum Dis. 2016; 19: 8-20.

  58. Mangat P et al. Bacterial and human peptidylarginine deiminases: targets for inhibiting the autoimmune response in rheumatoid arthritis? Arthritis Res Ther. 2010; 12: 209.

  59. Ortiz P et al. Periodontal therapy reduces the severity of active rheumatoid arthritis in patients treated with or without tumor necrosis factor inhibitors. J Periodontol. 2009; 80: 535-540.

  60. Pinho Mde N et al. Relationship between periodontitis and rheumatoid arthritis and the effect of non-surgical periodontal treatment. Braz Dent J. 2009; 20: 355-364.

  61. Biyikoglu B et al. Periodontal therapy in chronic periodontitis lowers gingival crevicular fluid interleukin-1beta and DAS28 in rheumatoid arthritis patients. Rheumatol Int. 2013; 33: 2607-2616.

  62. Erciyas K et al. Effects of periodontal therapy on disease activity and systemic inflammation in rheumatoid arthritis patients. Oral Dis. 2013; 19: 394-400.

  63. Monsarrat P et al. Effect of periodontal treatment on the clinical parameters of patients with rheumatoid arthritis: study protocol of the randomized, controlled ESPERA trial. Trials. 2013; 14: 253.

  64. Al-Katma MK et al. Control of periodontal infection reduces the severity of active rheumatoid arthritis. J Clin Rheumatol. 2007; 13: 134-137.

  65. Okada M et al. Periodontal treatment decreases levels of antibodies to Porphyromonas gingivalis and citrulline in patients with rheumatoid arthritis and periodontitis. J Periodontol. 2013; 84: e74-e84.

  66. Kurgan Ş et al. The effects of periodontal therapy on gingival crevicular fluid matrix metalloproteinase-8, interleukin-6 and prostaglandin E2 levels in patients with rheumatoid arthritis. J Periodontal Res. 2016; 51 (5): 586-595.

  67. Roman-Torres CV et al. An evaluation of non-surgical periodontal therapy in patients with rheumatoid arthritis. Open Dent J. 2015; 9: 150-153.

  68. Kaur S et al. Does periodontal treatment influence clinical and biochemical measures for rheumatoid arthritis? A systematic review and meta-analysis. Semin Arthritis Rheum. 2014; 44: 113-122.

  69. Thomas AM et al. Alcohol and tobacco consumption affects bacterial richness in oral cavity mucosa biofilms. BMC Microbiol. 2014; 14: 250.

  70. Wegner N et al. Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and alpha-enolase: implications for autoimmunity in rheumatoid arthritis. Arthritis Rheum. 2010; 62: 2662-2672.

  71. Wade WG. The oral microbiome in health and disease. Pharmacol Res. 2013; 69: 137-143.




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