2015, Número 3
<< Anterior Siguiente >>
Rev Cubana Farm 2015; 49 (3)
Componentes químicos, actividad y usos terapéuticos, de Scutia buxifolia Reissek
Calil BJ, Palermo MM
Idioma: Ingles.
Referencias bibliográficas: 57
Paginas: 557-568
Archivo PDF: 129.30 Kb.
RESUMEN
Scutia buxifolia se utiliza en el tratamiento de una serie de enfermedades que
incluye infecciones bacterianas y fúngicas, hipertensión, enfermedad de Alzheimer y cáncer.
S. buxifolia contiene compuestos biológicamente activos tales como
flavonoides, taninos, esteroides, lípidos, terpenos y alcaloides. A partir del extracto
y las fracciones de la planta surgen una gama de actividades biológicas, que
incluyen antioxidante, inhibidor de la acetilcolinesterasa, antiviral y antibiótico.
Se realizaron algunos estudios sobre el potencial tóxico, sin embargo los resultados
no son concluyentes, lo que sugiere que una sola administración del extracto es
segura, mientras que el uso prolongado tiene efectos perjudiciales para el
organismo. Las bases de datos revisadas fueron
SciELO, PubMed, ScienceDirect y
Portal de Capes, teniendo en cuenta los estudios entre 1964 y 2014 y mediante la
búsqueda de términos como
Scutia buxifolia, Rhamnaceae family, Scutia buxifolia
constituents, Scutia buxifolia uses and OECD.
REFERENCIAS (EN ESTE ARTÍCULO)
Alvim NAT, Ferreira MA, Cabral IE, Almeida Filho AJ. O uso de plantas medicinais como recurso terapêutico: das influências da formação profissional às implicações éticas e legais de sua aplicabilidade como extensão da prática de cuidar realizada pela enfermeira. Rev Latino-Am Enfermagem. 2006;14(3):316-323.
Mengue SS, Mentz LA, Schenkel EP. Uso de plantas medicinais na gravidez. Rev Bras Farmacogn. 2001;11(1):21-35.
Wasicky R, Wasicky M, Joachimovits R. Erstuntersuchungen na Coronilha-Scutia buxifolia Reissek. Planta Med. 1964; 12:13-25.
Sobral M, Jarenkow JA, Brack P, Irgang B, Larocca J, Rodrigues RS. Flora Arbórea e Arborescente do Rio Grande do Sul, Brasil. São Carlos: Novo Ambiente; 2006.
Boligon AA, Magoga BR, Feltrin AC, Janovik V, Athayde ML. Potencial antioxidante in vitro, conteúdo de fenóis e flavonóides nos ramos de Scutia buxifolia Reissek. Saúde. 2009;35(1):34-38.
Boligon AA, De Brum TF, Frolhich JK, Froeder ALF, Athayde ML. HPLC/DAD Profile and determination of total phenolics, flavonoids, tannins and alkaloids contents of Scutia buxifolia Reissek Stem Bark. Research Journal of Phytochemistry. 2012;6(3):84-91.
Boligon AA, Feltrin AC, Machado MM, Janovik V, Athayde ML. HPLC Analysis and phytoconstituents isolated from ethyl acetate fraction of Scutia buxifolia Reiss. Leaves. Latin American Journal of Pharmacy. 2009;28(1):121-124.
Bohm H, Boeing H, Hempel J, Raab B, Kroke A. Flavonols, flavones and anthocyanins as native antioxidants of food and their possible role in the prevention of chronic diseases. Zeitschrift fur Ernahrungswissenschaft. 1998;37:147-163.
Sakanashi Y, Oyama K, Matsui H, Oyama TB, Oyama TM, Nishimura Y et al. Possible use of quercetin, an antioxidant, for protection of cells suffering from overload of intracellular Ca2+: a model experiment. Life Sci. 2008;83(5-6):164-9.
Abdalla DSP, Sena KCM. Lipid peroxidation biomarkers in atherosclerosis. Rev Nutr. 2008;21(6):749-756.
Balazs L, Leon M. Evidence of an oxidative challenge in the Alzheimer's brain. Neurochem Res. 1994;19(9):1131-7.
Metodiewa D, Kochman A, Karolczak S. Evidence for antiradical and antioxidant properties of four biologically active N,N-diethylaminoethyl ethers of flavanone oximes: a comparison with natural polyphenolic flavonoid (rutin) action. Biochem Mol Biol Int. 1997;41(5):1067-75.
Azevedo MI, Pereira AF, Nogueira RB, Rolim FE, Brito GAC, Wong DVT et al. The antioxidant effects of the flavonoids rutin and quercetin inhibit oxaliplatininduced chronic painful peripheral neuropathy. Molecular Pain. 2013;9:53-67.
Rodrigues HG, Diniz YS, Faine LA, Almeida JA, Fernandes AAH, Novelli ELB. Suplementação nutricional com antioxidantes naturais: efeito da rutina na concentração de colesterol-HDL. Rev Nutr. 2003;16(3):315-320.
Pinto E, Vale-Silva L, Cavaleiro C, Salgueiro L. Antifungal activity of the clove essential oil from Syzygium aromaticum on Candida, Aspergillus and dermatophyte species. J Med Microbiol. 2009;58(11):1454-1462.
Boligon AA, Janovik V, Frohlich JK, Froeder ALF, Alves SH, Athayde ML. Antimicrobial and cytotoxic activities of leaves, twigs and stem bark of Scutia buxifolia Reissek. Nat Prod Res. 2012;26:939-944.
Boligon AA, De Brum TF, Frohlich JK, Zadra M, Froeder ALF, Gindri AL et al. Quantificação de β-sitosterol e estigmasterol nas cascas do tronco e folhas de Scutia buxifolia Reissek. SEPE–XV Simpósio de ensino, pesquisa e extensão. Santa Maria: SEPE; 2011.
Pegel KH. The importance of sitosterol and sitosterolin in human and animal nutrition. S Afr J Sci. 1997;93: 263-268.
Bouic PJ, Etsebeth S, Liebenberg RW, Albrecht CF, Pegel K, Van Jaarsveld PP. Beta-sitosterol and beta-sitosterol glucoside stimulate human peripheral blood lymphocyte proliferation: implications for their use as na immunomodulatory vitamin combination. Int J Immunopharmac. 1996;18:693-700.
Awad AB, Gan Y, Fink CS. Phytosterols as anticancer dietary components: evidence and mechanism of action. Nutr Cancer. 2000;36:74-78.
Boligon AA, Schwanz TG, Froeder ALF, Athayde ML. GC-MS Analysis of dichloromethane fractions of Scutia buxifolia Reissek leaves and stem bark. Research Journal of Phytochemistry. 2014;8(1):16-20.
Morrison IM, Asiedu EA, Stuchbury T, Powell AA. Determination of lignin and tannin contents of cow pea seed coats. Annal Botany. 1995;76:287-290.
Koleckar V, Kubikova K, Rehakova Z, Kuca K, Jun D, Jahodar L et al. Condensed and hydrolysable tannins as antioxidants influencing the health. Mini Rev Med Chem. 2008;8(5):436-47.
Zhang SJ, Lin YM, Zhou HC, Wei SD, Lin GHL, Ye GF. Antioxidant tannins from stem bark and fine root of Casuarina equisetifolia. Molecules. 2010;15:5658-5670.
Villani FA, Chiarra SS, Piccinini F. Effect of terpenes on the cell permeability to tetracycline. Arzneimittelforscung. 1972;22:1364-1367.
Tschesche R, Welters R, Fehlhaber HW. Scutianinm ein cyclisches Peptid- Alkaloid aus Scutia buxifolia Reiss. Chem. Ber. 1967;100:323.
Tschesche R, Ammermann E, Fehlhaber HW. Alkaloide aus rhamnaceen, X: Scutianin-B, ein weiteres Peptidalkaloid aus Scutia buxifolia Reiss. Tetrahedron Letters. 1971;12(46):4405-4408.
Sierra MG, Mascaretti OA, Merkuza VM, Tosti EL, Ruveda EA. Peptide alkaloids of Scutia buxifolia. Phytochemistry. 1974;13:2865-2869.
Tschesche R, Ammermann R. Alkaloide aus Rhamnaceen, XXIII. Scutianin-C, -D und -E, drei weitere Cyclopeptidalkaloide aus Scutia buxifolia Reiss. Chem. Ber. 1974;107:2274.
Tschesche R, Hillebrand D, Wilhelm H, Ammermann E, Eckhardt G. Hysodricanin-a, mauritin-h, scutianin-f und aralionin-c, vier weitere cyclopeptidalkaloide aus ziziph us, Scutia und araliorhamnus. Phytochemistry. 1977;16:1025.
Tschesche R, Hillebrand D. Scutianin-g, ein weiteres cyclopeptidalkaloid aus Scutia buxifolia. Phytochemistry. 1977;16:1817.
Menezes AS, Mostardeiro MA, Zanatta N, Morel AF. Scutianine-J, a cyclopeptidic alkaloid isolated from Scutia buxifolia. Phytochemistry. 1995;38(3):783-786.
Morel AF, Bravo RFB, Reis FAM, Ruveda EA. Peptide alkaloids of Scutia buxifolia. Phytochemistry. 1979;18:473-477.
Maldaner G, Marangon P, Ilha V, Caro MSB, Burrow RA, Dalcol II et al. Cyclopeptide alkaloids from Scutia buxifolia Reiss. Phytochemistry... 2011;72:804-809.
Morel AF, Machado ECS, Moreira JJ, Menezes AS, Mostardeiro MA, Zanatta N et al. Cyclopeptide alkaloids of Scutia buxifolia. Phytochemistry. 1998;47(1):125-129.
Marangon P, Morel AF, Maldaner G, Silva UF, Dalcol II. Comparação de metabólitos secundários de Scutia buxifolia por CLAE. XXII Simpósio de plantas medicinais do Brasil. Bento Gonçalves: SBQ; 2012.
Emile A, Waikedre J, Herrenknecht C, Fourneau C, Gantier JC, Hnawia E et al. Bioassay-guided isolation of antifungal alkaloids from Melochia odorata. Phytother Res. 2007;21:398-400.
Lin HY, Chem CH, You BJ, Liu KCS, Lee SS. Cyclopeptide alkaloids from Paliurus ramossisimus. J Nat Prod. 2000;63:1338-1343.
Boligon AA, Schwanz TG, De Brum TF, Frohlich JK, Nunes L, Mario DN et al. Chemical composition, antioxidant and antimicrobial activities of the essential oil of Scutia buxifolia Reissek leaves. Pharmaceut. Anal. Acta. 2012;3:10.
Chinou IB, Bougatsos C, Perdetzouglou D. Chemical composition and antimicrobial activities of Helichrysum amorginum cultivated in Greece. Journal of Essential Oil Research. 2004;16:243-245.
Burt S. Essential oil: their antibacterial properties and potential applications in foods – A Review. Int. J. Food Microbiol. 2004;94:223-253.
Boligon AA, De Brum TF, Zadra M, Piana M, Alves CFS, Fausto VP et al. Antimicrobial activity of Scutia buxifolia against the honeybee pathogen Paenibacillus larvae. Journal of Invertebrate Pathology. 2013;112:105-107.
Boligon AA, Boligon AA, Lorentz LH, Mahlke JD, Machado MM, Orige SC et al. Estudo da atividade antimicrobiana de extratos e frações obtidos a partir dos ramos de Scutia buxifolia Reissek. Horticultura Brasileira. 2008;26(2):13-17.
Maldaner G, Ilha V, Giacomelli SR, Stuker CZ, Morel AF, Dalcol II et al. Estudo da relação estrutura atividade antimicrobiana de alcalóides ciclopeptídicos e ciclopeptídeo neutro de Condala buxifolia e Scutia buxifolia pertencentes à familia Rhamnaceae. 30a Reuniao Anual da Sociedade Brasileira de Química. Águas de Lindóia: SBQ; 2007.
Zhao Q, Tang XC. Effects of huperzine A on an acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine. Eur J Pharmacol. 2002;455(2-3):101-107.
Selkoe DJ. Alzheimer's Disease: genes, proteins, and therapy. Physiol Ver. 2001;81(2):741-66.
Sereniki A, Vital MABF. A Doença de Alzheimer: aspectos fisiopatológicos e farmacológicos. Ver. Rev Psiquiatr RS. 2008;30(1 Supl):1-17.
Bottina CMC, Carvalho IAM, Alvarez AMMA, Avila R, Zukauskas PR, Bustamante SEZ et al. Reabilitação cognitiva em pacientes com Doença de Alzheimer. Arq Neuropsiquiatr. 2002;60(1):70-79.
Maldaner G, Marangon P, Ilha V, Dalcol II, Morel AF, Adolpho L et al. Inibidores naturais da acetilcolinesterase isolados de Scutia buxifolia. 32a Reuniao Anual da Sociedade Brasileira de Química. Fortaleza: SBQ; 2009. 50. Boligon AA, Kubiça TF, Mario DN, De Brum TF, Piana M, Weiblen R et al. Antimicrobial and antiviral activity-guided fractionation from Scutia buxifolia Reissek extracts. Acta. Physiol. Plant. 2013;35:2229-2239.
Boligon AA, Pereira RP, Feltrin AC, Machado MM, Janovik V, Rocha JBT et al. Antioxidant activites of flavonol derivatives from the leaves and stem bark of Scutia buxifolia Reiss. Bioresource technology. 2009;100:6592-6598.
Da Silva RCVAF, Souza SCP, Boligon AA, Athayde ML, Santos ARS, Marques MCA et al. Endothelium-dependent and independent vasorelaxation induced by na n-butanolic fraction of bark of Scutia buxifolia Reiss (Rhamanaceae). J. Ethnopharmacol. 2012;141:997-1004.
Boligon AA, Sagrillo MR, Machado LF, Filho OS, Machado MM, Cruz IBM et al. Protective effects of extracts and flavonoids isolated from Scutia buxifolia Reissek against chromosome damage in human lymphocytes exposed to hydrogen peroxide. Molecules. 2012;17:5757-5769.
De Freitas RB, Rovani BT, Boligon AA, De Brum TF, Piana M, Jesus RS et al. Hepatotoxicity evaluation of aqueous extract from Scutia buxifolia. Molecules. 2013;18(7):7570-7583.
De Freitas RB, Araldi ICC, Boligon AA, De Brum TF, Rovani BT, Piana M et al. Phytochemical analysis and toxicity investigation of stem bark of Scutia buxifolia Reissek. Natural Product Research. 2013;27(18):1620-1624.
Grecco GA, Santos KT, Santanna LS, Moreira CM. Avaliação da toxicidade oral aguda do extrato aquoso de Scutia buxifolia Reiss em ratos. Anais do Salão Internacional de Ensino, Pesquisa e Extensão (SIEPE-Universidade Federal do Pampa) 2011;3(2).
Da Silva ARH, Moreira LR, Brum ES, De Freitas ML, Boligon AA, Athayde ML et al. Biochemical and hematological effects of acute and sub-acute administration to ethyl acetate fraction from the stem bark Scutia buxifolia Reissek in mice. Journal of Ethnopharmacology. 2014;153(3):908-916.
Da Silva ARH, Moreira LR, Brum ES, De Freitas ML, Boligon AA, Athayde ML et al. Biochemical and hematological effects of acute and sub-acute administration to ethyl acetate fraction from the stem bark Scutia buxifolia Reissek in mice. Journal of Ethnopharmacology. 2014;153(3):908-916.