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Instituto Nacional de Neurología y Neurocirugía

2005, Número 1

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Arch Neurocien 2005; 10 (1)


Determinación de adenosina desaminasa (lada) en líquido cefalorraquídeo (LCR) como auxiliar diagnóstico en meningitis por tuberculosis

Zuñiga-Ramírez C, Soto-Hernández JL

Idioma: Español
Referencias bibliográficas: 58
Paginas: 2-8
Archivo PDF: 171.76 Kb.


RESUMEN

La determinación de la enzima adenosina disaminasa ha sido ensayada en diferentes líquidos y desde 1973 se sugiere que este elevada en el líquido cefalorra-quídeo en la meningitis tuberculosa aunque existen opiniones en pro y en contra. Se hizo un estudio de 332 muestras de LCR en pacientes con diferentes enfermedades neurológicas entre ellos algunos con probada presencia de la micobacteria. En nuestra opinión la prueba de adenosina desaminasa es un método auxiliar eficaz de bajo costo y gran rapidez para confirmar la sospecha tuberculosis del sistema nervioso. Su sensibilidad es de un 64 % en nuestro estudio, pero su negatividad no descarta la tuberculosis y el tratamiento lo altera.


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