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2016, Número 1

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Rev Cubana Plant Med 2016; 21 (1)


Revisión sistemática de las plantas de interés para el Sistema de Salud con potencial terapéutico cardiovascular

Marmitt DJ, Rempel C, Goettert MI, do Couto SA, Fernández PCN

Idioma: Portugués
Referencias bibliográficas: 62
Paginas: 108-124
Archivo PDF: 347.07 Kb.


RESUMEN

Introducción: las enfermedades cardiovasculares constituyen una de las principales causas de mortalidad, al existir muchos factores de riesgo asociados a su aparición. Hay estudios que demuestran que moléculas extraídas de plantas medicinales pueden reducir el riesgo de enfermedades crónicas. De esta forma, el Ministerio de Salud, publicó en febrero de 2009, la Lista Nacional de Plantas Medicinales de Interés para el SUS.
Objetivos: cuantificar los estudios clínicos que refieren potencial terapéutico sobre las enfermedades cardiovasculares a partir de la utilización de Plantas da Medicinais de Interesse ao SUS, publicados entre 2010 y febrero de 2013 en tres bases de datos científicas (SciELO, Science Direct y Springer).
Métodos: los descriptores utilizados en la búsqueda inicial fueron el nombre científico de 71 plantas de Plantas da Medicinais de Interesse ao SUS. Se consideraron todos los artículos científicos gratuitos, disponibles en texto completo en las bases de investigación, independiente del idioma. Primero se seleccionaron 21,357 artículos encontrados en las bases de datos. El análisis fue realizado a partir de la lectura del título de publicación. Los artículos seleccionados fueron evaluados a través de la lectura del Abstract. Por último, fueron leídos de forma íntegra el texto de los artículos seleccionados después de la evaluación del Abstract, fueron seleccionados estudios preclínicos y clínicos in vitro e in vivo, que comprueban el potencial terapéutico sobre las enfermedades cardiovasculares.
Resultados: esta selección resultó de 34 artículos de interés, de los cuales, 17 estudios fueron realizados con la planta Curcuma longa. Infarto de miocardio, isquemia cerebral e hipertensión arterial fueron las comorbilidades con la mayor cantidad de estudios terapéuticos.
Conclusiones: los resultados de este estudio ofrecen subsidios teóricos para discusiones en Salud Pública sobre tratamientos alternativos para las enfermedades cardiovasculares.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause 1990–2020: Global burden of disease study. Lancet. 1997;349:1498–504.

  2. World Health Organization. Cardiovascular diseases (CVDs). 2015 [citado Mar 2015]. Disponível em: http://www.who.int/mediacentre/factsheets/fs317/en/

  3. Wang Y, Beydoun MA, Liang L, Caballero B, Kumanyiaka SK. Will all Americans become overweight or obese? Estimating the progression and cost of the US obesity epidemic. Obesity (Silver Spring). 2008;16(10):2323-30.

  4. Kumar A, Zandi P. Plant Nutraceuticals for Cardiovascular Diseases with Special Emphasis to the Medicinal Herb Fenugreek (Trigonella Foenum-Graecum L.). American Journal of Social Issues and Humanities. 2014;4(3):177-89.

  5. World Health Organization. Global Health Observatory (GHO) data. NCD mortality and morbidity. 2013 [citado Mar 2015]. Disponível em: http://www.who.int/gho/ncd/mortality_morbidity/en/

  6. Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Medicine. 2006;3:e442.

  7. World Health Organization. The top 10 causes of death. The 10 leading causes of death in the world, 2000 and 2012. 2014 [citado Mar 2015]. Disponível em: http://www.who.int/mediacentre/factsheets/fs310/en/

  8. Tibazarwa KB, Damasceno AA. Hypertension in developing countries. Canadian Journal of Cardiology. 2014;30:527-33.

  9. Nichols M, Townsend N, Luengo-Fernandez R, Leal J, Gray A, Scarborough P, et al. European Cardiovascular Disease Statistics 2012 European Heart Network. European Society of Cardiology, Brussels/Sophia Antipolis; 2012. p. 129.

  10. Xavier HT, Izar MC, Faria Neto JR, Assad MH, Rocha VZ, Sposito AC, et al. V Diretriz Brasileira de Dislipidemias e Prevenção da Aterosclerose. Arquivos Brasileiros de Cardiologia. 2013;101(4):1-20.

  11. Figueiredo EL, Machado FP. Os papéis da digoxina em pacientes com insuficiência cardíaca. Insuficiencia cardíaca. 2010;5(2):59-64.

  12. Shukla SK, Gupta S, Ojha SK, Sharma SB. Cardiovascular friendly natural products: a promising approach in the management of CVD. Natural Product Research. 2010;24(9):873-98.

  13. Schnabel R, Blankenberg S. Oxidative Stress in Cardiovascular Disease Successful Translation From Bench to Bedside? Circulation. 2007;116:1338-40.

  14. World Health Organization. Cuidados de Saúde Primários: Agora mais do que nunca. Geneva. 2008 [citado Ago 2015]. p. 156 Disponível em: http://www.who.int/whr/2008/whr08_pr.pdf

  15. Brasil. Ministério da Saúde. Portal da Saúde: Programa Nacional de Plantas Medicinais e Fitoterápicos. 2009 [citado Feb 2015]. Disponível em: http://portalsaude.saude.gov.br/images/pdf/2015/janeiro/05/programa-nacionalplantas- medicinais-fitoter--picos-pnpmf.pdf

  16. Nakmareong S, Kukongviriyapan U, Pakdeechote P, Donpunha W, Kukongviriyapan V, Kongyingyoes B, et al. Antioxidant and vascular protective effects of curcumin and tetrahydrocurcumin in rats with L-NAME-induced hypertension. Naunyn-Schmiedeberg's Archives of Pharmacology. 2011;383(5):519-29.

  17. Awad AS, El-Sharif AA. Curcumin immune-mediated and anti-apoptotic mechanisms protect against renal ischemia/reperfusion and distant organ induced injuries. International Immunopharmacology. 2011;11(8):992-6.

  18. Prakash P, Misra A, Surin WR, Jain M, Bhatta RS, Pal R, et al. Anti-platelet effects of Curcuma oil in experimental models of myocardial ischemia-reperfusion and thrombosis. Thrombosis Research. 2011;127(2):111-8.

  19. Fleenor BS, Sindler AL, Marvi NK, Howell KL, Zigler ML, Yoshizawa M, et al. Curcumin ameliorates arterial dysfunction and oxidative stress with aging. Experimental Gerontology. 2013;48(2):269-76.

  20. Fan J, Li X, Yan YW, Tian XH, Hou WJ, Tong H, et al. Curcumin attenuates rat thoracic aortic aneurysm formation by inhibition of the c-Jun N-terminal kinase pathway and apoptosis. Nutrition. 2012;28(10):1068-74.

  21. Soetikno V, Sari FR, Sukumaran V, Lakshmanan AP, Mito S, Harima M, et al. Curcumin prevents diabetic cardiomyopathy in streptozotocin-induced diabetic rats: possible involvement of PKC-MAPK signaling pathway. European Journal of Pharmaceutical Sciences. 2012;47(3):604-14.

  22. González Salazar A, Molina Jijón E, Correa F, Zarco Márquez G, Calderón Oliver M, Tapia E, et al. Curcumin protects from cardiac reperfusion damage by attenuation of oxidant stress and mitochondrial dysfunction. Cardiovascular Toxicology. 2011;11(4):357-64.

  23. Kim YS, Kwon JS, Cho YK, Jeong MH, Cho JG, Park JC, et al. Curcumin reduces the cardiac ischemia-reperfusion injury: involvement of the toll-like receptor 2 in cardiomyocytes. The Journal of Nutritional Biochemistry. 2012;23(11):1514-23.

  24. Tyagi N, Qipshidze N, Munjal C, Vacek JC, Metreveli N, Givvimani S, et al. Tetrahydrocurcumin ameliorates homocysteinylated cytochrome-c mediated autophagy in hyperhomocysteinemia mice after cerebral ischemia. Journal of Molecular Neuroscience. 2012;47(1):128-38.

  25. Awad AS. Effect of combined treatment with curcumin and candesartan on ischemic brain damage in mice. Journal of Stroke and Cerebrovascular Diseases. 2011;20(6):541-8.

  26. Avci G, Kadioglu H, Sehirli AO, Bozkurt S, Guclu O, Arslan E, et al. Curcumin protects against ischemia/reperfusion injury in rat skeletal muscle. Journal of Surgical Research. 2012;172(1):e39-46.

  27. Lee SW, Nah SS, Byon JS, Ko HJ, Park SH, Lee SJ, et al. Transient complete atrioventricular block associated with curcumin intake. International Journal of Cardiology. 2011;15;150(2):e50-2.

  28. Yucel AF, Kanter M, Pergel A, Erboga M, Guzel A. The role of curcumin on intestinal oxidative stress, cell proliferation and apoptosis after ischemia/reperfusion injury in rats. Journal of Molecular Histology. 2011;42(6):579-87.

  29. Duan W, Yang Y, Yan J, Yu S, Liu J, Zhou J, et al. The effects of curcumin posttreatment against myocardial ischemia and reperfusion by activation of the JAK2/STAT3 signaling pathway. Basic Research in Cardiology. 2012;107(3):263.

  30. Hong da H, Son YK, Choi IW, Park WS. The inhibitory effect of curcumin on voltage-dependent K⁺ channels in rabbit coronary arterial smooth muscle cells. Biochemical and Biophysical Research Communications. 2013;4;430(1):307-12.

  31. Akazawa N, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, et al. Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women. Nutrition Research. 2012;32(10):795-9.

  32. Kim DC, Lee W, Bae JS. Vascular anti-inflammatory effects of curcumin on HMGB1- mediated responses in vitro. Inflammation Research. 2011 Dec;60(12):1161-8.

  33. Dubey H, Singh A, Patole AM, Tenpe CR, Ghule BV. Allicin, a SUR2 opener: possible mechanism for the treatment of diabetic hypertension in rats. Brazilian Journal of Pharmacognosy. 2012;22(5):1053-59.

  34. Zhu JW, Chen T, Guan J, Liu WB, Liu J. Neuroprotective effects of allicin on spinal cord ischemia-reperfusion injury via improvement of mitochondrial function in rabbits. Neurochemistry International. 2012;61(5):640-8.

  35. Liu Y, Qi H, Wang Y, Wu M, Cao Y, Huang W, et al. Allicin protects against myocardial apoptosis and fibrosis in streptozotocin-induced diabetic rats. Phytomedicine. 2012;19(8-9):693-8.

  36. Xing Y, Chen J, Wang J, Gao Y, Niu W, Zhao M, et al. The effects of allitridi and amiodarone on the conduction system and reverse use-dependence in the isolated hearts of rats with myocardial infarction. Journal of Ethnopharmacology. 2012;141(2):674-84.

  37. Yodjun M, Karnchanatat A, Sangvanich P. Angiotensin I-converting enzyme inhibitory proteins and peptides from the rhizomes of Zingiberaceae plants. Applied Biochemistry and Biotechnology. 2012;166(8):2037-50.

  38. Jittiwat J, Wattanathorn J. Ginger pharmacopuncture improves cognitive impairment and oxidative stress following cerebral ischemia. Journal of Acupuncture and Meridian Studies. 2012;5(6):295-300.

  39. Plengsuriyakarn T, Viyanant V, Eursitthichai V, Picha P, Kupradinun P, Itharat A, et al. Anticancer activities against cholangiocarcinoma, toxicity and pharmacological activities of Thai medicinal plants in animal models. BMC Complementary and Alternative Medicine. 2012;12(23):1-17.

  40. de Souza P, Gasparotto AJr, Crestani S, Stefanello MÉ, Marques MC, da Silva- Santos JE, et al. Hypotensive mechanism of the extracts and artemetin isolated from Achillea millefolium L. (Asteraceae) in rats. Phytomedicine. 2011;18(10):819-25.

  41. Dall'Acqua S, Bolego C, Cignarella A, Gaion RM, Innocenti G. Vasoprotective activity of standardized Achillea millefolium extract. Phytomedicine. 2011;18(12):1031-6.

  42. Zhou JY, Zhou SW. Isorhynchophylline: A plant alkaloid with therapeutic potential for cardiovascular and central nervous system diseases. Fitoterapia. 2012;83(4):617-26.

  43. VattimoI MFF, da Silva NO. Uncaria tomentosa and acute ischemic kidney injury in rats. Revista da Escola de Enfermagem da USP. 2011;45(1):194-8.

  44. Dana N, Javanmard SH, Asgary S, Asnaashari H, Abdian N. The effect of Aloe vera leaf gel on fatty streak formation in hypercholesterolemic rabbits. International Journal of Research in Medical Sciences. 2012;17(5):439-42.

  45. Santos BA, Roman-Campos D, Carvalho MS, Miranda FM, Carneiro DC, Cavalcante PH, et al. Cardiodepressive effect elicited by the essential oil of Alpinia speciosa is related to L-type Ca²+ current blockade. Phytomedicine. 2011;18(7):539-43.

  46. ParenteI LML, AndradeII MA, BritoII LAB, de Moura VMBD, Miguel MP, Lino-Júnior RS, et al. Angiogenic activity of Calendula officinalis flowers L. in rats. Acta Cirúrgica Brasileira. 2011;26(1):19-24.

  47. Silva MCC, Santana LA, Silva-Lucca RA, Lima ALR, Ferreira JG, Paiva PMG, et al. Immobilized Cratylia mollis lectin: An affinity matrix to purify a soybean (Glycine max) seed protein with in vitro platelet antiaggregation and anticoagulant activities. Process Biochemistry. 2011;46(1):74-80.

  48. Malik ZA, Singh M, Sharma PL. Neuroprotective effect of Momordica charantia in global cerebral ischemia and reperfusion induced neuronal damage in diabetic mice. Journal of Ethnopharmacology. 2011;133(2):729-34.

  49. Mohan M, Patankar P, Ghadi P, Kasture S. Cardioprotective potential of Punica granatum extract in isoproterenol-induced myocardial infarction in Wistar rats. J Pharmacol Pharmacother. 2010;1(1):32-7.

  50. Mashour NH, Lin GI, Frishman WH. Herbal Medicine for the Treatment of Cardiovascular Disease. Archives of Internal Medicine. 1998;158(20):2225-34.

  51. Tyler VE. Herbs of Choice: The Therapeutic Use of Phytomedicinals. Pharmaceutical Product Press; 1994. p. 107-8.

  52. Tumcok Y, Kozan O, Cadvar C. Urginea maritima (squill) toxicity. J Toxicol Clin Toxicol. 1995;33:83-6.

  53. Yang GY, Wang W. Clinical studies on the treatment of coronary heart disease with Valeriana officinalis var latifolia. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1994;14(9):540-2.

  54. Azmi MB, Qureshi SA. Methanolic Root Extract of Rauwolfia serpentina Benth Improves the Glycemic, Antiatherogenic, and Cardioprotective Indices in Alloxan- Induced Diabetic Mice. Advances in Pharmacological Sciences; 2012.

  55. Lee CH, Kim JH. A review on the medicinal potentials of ginseng and ginsenosides on cardiovascular diseases. Journal of Ginseng Research. 2014;38(3):161-6.

  56. Zhao BL, Jiang W, Zhao Y, Hou JW, Xin WJ. Scavenging effects of Salvia miltiorrhiza on free radicals and its protection for myocardial mitochondrial membranes from ischemia-reperfusion injury. Biochemistry and Molecular Biology International Journal. 1996;38:1171-82.

  57. Chan K, Lo AC, Yeung JH, Woo KS. The effects of Danshen (Salvia miltiorrhiza) on warfarin pharmacodynamics and pharmacokinetics of warfarin enantiomers in rats. Journal of Pharmacology and Pharmacotherapeutics. 1995;47:402-6.

  58. Kleinjen J, Knipschild P. Ginkgo biloba for cerebral insufficiency. British Journal of Clinical Pharmacology. 1992;34:352-8.

  59. Allard M. Treatment of the disorders of aging with Ginkgo biloba extract. La Presse Médicale. 1986;15:1540-5.

  60. Facino RM, Carini M, Stefani R, Aldini G, Saibene L. Anti-elastase and antihyaluronidase activities of saponins and sapogenins from Hedera helix, Aesculus hippocastanum, and Ruscus aculeatus: factors contributing to their efficacy in the treatment of venous insufficiency. Archiv der Pharmazie; 1995. p. 328, 720-24.

  61. Golan DE, Armstrong EJ, Armstrong AW, Vahle JL, Tashjian JAH. Princípios de Farmacologia-A Base Fisiopatológica da Farmacoterapia. 2da. ed. Rio de Janeiro: Editora Guanabara Koogan; 2009. p. 908.

  62. Gurib-Fakim A. Medicinal plants: traditions of yesterday and drugs of tomorrow. Molecular Aspects of Medicine. 2006;27(1):1-93.




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