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2014, Número 2

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MEDICC Review 2014; 16 (2)


La enfermedad renal crónica en las comunidades agrícolas de América Central: desafíos para la epidemiología y la salud pública

Silva ALC, Ordúñez GP

Idioma: Español
Referencias bibliográficas: 58
Paginas: 66-71
Archivo PDF: 135.91 Kb.


RESUMEN

Este trabajo contextualiza la epidemia de enfermedad renal crónica y la carga de enfermedad relacionada que afecta a las comunidades agrícolas de la América Central. Se analizan las dos hipótesis principales (estrés por calor y agroquímicos), se llama la atención acerca de las consecuencias del razonamiento dicotómico concerniente a la causalidad, y se precave sobre el potencial conflicto de intereses y su papel en “la construcción de la duda”. Se describen algunos errores metodológicos que comprometen los resultados de estudios anteriores y se advierte acerca del peligro de dilatar las acciones de la salud pública hasta que se alcance una comprensión concluyente en relación con las causas de la epidemia y de los mecanismos subyacentes. Se fundamenta la necesidad de un enfoque integral de los hechos históricos, epidemiológicos y sociales de la epidemia, para valorar críticamente los estudios existentes e incrementar el rigor de nuevas investigaciones.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. García R, Aguilar R, Reyes C, Ortiz M, Leiva R. Nefropatía terminal en pacientes de un hospital de referencia en El Salvador. Rev Panam Salud Pública. 2002; 12(3):202–6. Spanish.

  2. Pan American Health Organization. Resolution CD52.R1. Chronic kidney disease in agricultural communities in Central America [Internet]. Washington, DC: Pan American Health Organization; 2013 [cited 2013 Jun 13]. 2 p. Available from: www.paho.org/hq/index.php?option=com_doc man&task=doc_download&gid=23222&Itemid=2 70&lang=en

  3. Torres C, Aragón A, González M, López I, Jakobsson K, Elinder CG, et al. Decreased kidney function of unknown cause in Nicaragua: a community-based survey. Am J Kidney Dis. 2010 Mar;55(3):485–96.

  4. Orantes CM, Herrera R, Almaguer M, Brizuela EG, Hernández CE, Bayarre H, et al. Chronic Kidney Disease and associated risk factors in the Bajo Lempa region of El Salvador: Nefrolempa study. MEDICC Rev. 2011 Apr;13(4):14–22.

  5. Brooks DR, Ramirez O, Amador JJ. CKD in Central America: A hot issue. Am J Kidney Dis. 2012 Apr;59(4):481–4.

  6. Correa R, Wesseling C, Johnson RJ. CKD of unknown origin in Central America: the case for a Mesoamerican nephropathy. Am J Kidney Dis. 2014 Mar;63(3):506–20.

  7. Pan American Health Organization [Internet]. Washington, DC: Pan American Health Organization; c2014. Visualizing renal failure and chronic kidney diseases age-standardized mortality rate in countries of the Americas, 2000–2009. Non-communicable Diseases and Mental Health; 2014 [cited 2014 Mar 13]; [about 1 screen]. Available from: http://ais.paho.org/phip/viz/nmh _renalfailure_ckd_visualization.asp

  8. Institute of Health Metrics and Evaluation 2012. Global Burden of Diseases [Internet]. Seattle: Institute of Health Metric and Evaluation; 2013 Mar [cited 2013 Oct 20]; [about 1 screen]. Available from: http://www.healthmetricsandeva luation.org/gbd/visualizations/gbd-arrow-diagram

  9. International Consortium of Investigative Journalists [Internet]. Washington, DC: Center for Public Integrity; c2012–2014. Thousands of sugar cane workers die as wealthy nations stall on solutions; 2011 Dec 12 [cited 2014 Mar 14]; [about 5 screens]. Available from: http://www.icij.org/ project/island-widows/thousands-sugar-cane -workers-die-wealthy-nations-stall-solutions

  10. Salinas C. La muerte acecha a los cañeros. Periódico El País (Spain) [Internet]. 2012 Feb 11 [cited 2014 Mar 2]; Portada: [about 3 p.]. Available from: http://internacional.elpais.com/interna cional/2012/02/11/actualidad/1328991118_487 033.html. Spanish.

  11. Sheehy K. Mystery kidney disease in Central America. BBC News [Internet]. 2011 Dec 13 [cited 2014 Mar 4]; Home: [about 3 p.]. Available from: http://www.bbc.co.uk/news/magazine-16007129

  12. Declaración de San Salvador. Abordaje integral de la enfermedad renal túbulo-intersticial crónica de Centroamérica (ERTCC) que afecta predominantemente a las comunidades agrícolas [Internet]. San Salvador: Ministry of Health of El Salvador; 2013 Apr [cited 2014 Mar 2]. 6 p. Available from: http://www.salud.gob.sv/ archivos/comunicaciones/archivos_comunica dos2013/pdf/Declaracion_San%20Salvador _ERCnT_26042013.pdf. Spanish.

  13. Wesseling C, Crowe J, Hogstedt C, Jakobsson K, Lucas R, Wegman D, editors. Mesoamerican Nephropathy. Report from the First International Research Workshop on MeN [Internet]. San Jose (CR): SALTRA; 2012 [cited 2014 Mar 2]. 255 p. Available from: http:// www.regionalnephropathy.org/wp-content/ uploads/2013/04/Technical-Report-for-Website -Final.pdf

  14. Crowe J, Moya JM, Román B, Robles A. Heat exposure in sugarcane workers in Costa Rica during the non-harvest season. Glob Health Action. 2010 Nov 29;3.

  15. Peraza S, Wesseling C, Aragon A, Leiva R, García RA, Torres C, et al. Decreased kidney function among agricultural workers in El Salvador. Am J Kidney Dis. 2012 Apr;59(4):531–40.

  16. Crowe J, Wesseling C, Solano BR, Umaña MP, Ramírez AR, Kjellstrom T, et al. Heat exposure in sugarcane harvesters in Costa Rica. Am J Ind Med. 2013 Oct;56(10):1157–64.

  17. Roncal CA, Ishimoto T, Lanaspa MA, Rivard CJ, Nakagawa T, Ejaz AA, et al. Fructokinase activity mediates dehydration-induced renal injury. Kidney Int. 2013 Dec 11. doi: 10.1038/ki.2013.492. [Epub ahead of print]

  18. Aragón A, Aragón C, Thörn Å. Pests, peasants, and pesticides on the Northern Nicaraguan Pacifi c Plain. Int J Occup Environl Health. 2001 Oct–Dec;7(4):295–302.

  19. McConnell R, Pacheco AF, Magnotti R. Crop duster aviation mechanics: high risk for pesticide poisoning. Am J Public Health. 1990 Oct:80(10):1236–9.

  20. Morgan DP, Roan CC. Renal function in persons occupationally exposed to pesticides. Arch Environ Health. 1969 Nov;19(5):633–6.

  21. Jayatilake N, Mendis S, Maheepala P, Mehta FR; CKDu National Research Project Team. Chronic kidney disease of uncertain aetiology: prevalence and causative factors in a developing country. BMC Nephrol. 2013 Aug 27;14:180.

  22. Jayasumana MACS, Paranagama PA, Amarasinghe MD, Wijewardane KMRC, Dahanayake KS, Fonseka SI, et al. Posible link of chronic arsenic toxicity with chronic kidney disease of unknown etiology in Sri Lanka. J Nat Sci Res. 2013;3(1):64–73.

  23. Ferraro PM, Costanzi S, Naticchia A, Sturniolo A, Gambaro G. Low level exposure to cadmium increases the risk of chronic kidney disease: analysis of the NHANES 1999–2006. BMC Public Health. 2010 Jun 3;10:304.

  24. Botti C, Comba P, Forastiere F, Settimi L. Causal inference in environmental epidemiology: the role of implicit values. Sci Total Environ. 1996; 84:97–101.

  25. Morabia A, editor. Epidemiology: an epistemological perspective. In: A history of epidemiologic methods and concepts. Basel (CH): BirkhauserVerlag; 2004.

  26. Hill AB. The environment and disease. Association or causation? Proc R Soc Med. 1965 May;58(5):295–300.

  27. Grimes DA, Schulz KF. Bias and causal associations in observational research. Lancet. 2002 Jan 19;359(9302):248–52.

  28. Michaels D. Doubt is their product. How industry’s assault on science threatens your health. Oxford: Oxford University Press; 2008 May. 388 p.

  29. Ramírez M. Nefrólogos no apoyan tesis de tóxicos y mal renal. Estudios sobre exposición de pesticidas no han encontrado relación entre los tóxicos con la insufi ciencia renal crónica. Periódico El diario de hoy (San Salvador). 2013 Aug 29. Spanish.

  30. Rodríguez CA. La salud de los trabajadores: entre la ciencia y la ética. Salud Colectiva. 2013;9(2):133–7. Spanish.

  31. Smith R. Confl ict of interest and the BMJ. Time to take it more seriously. Br Med J. 1994; 308 (6920):4–5.

  32. Angell M. The truth about the drug companies: how they deceive us and what to do about it. New York: Random House; 2005 Aug 9. 319 p.

  33. Gøtzsche PC. Deadly medicines and organized crime: how big pharma has corrupted healthcare. London: Radclife Medical Press; 2013 Aug 31. 310 p.

  34. Salsburg D. The lady tasting tea: how statistics revolutionized science in the twentieth century. New York: Henry Holt & Co.; 2002 May. p. 38.

  35. Doll RA, Hill AB. Smoking and carcinoma of the lung: preliminary report. Br Med J. 1950 Sep 30;2(4682):739–48.

  36. Fisher RA. Cigarettes, cancer and statistics. Centen Rev. 1958;2:151–66.

  37. Silva LC, Benavides A. Causalidad e inobservancia de la premisa de precedencia temporal. Revista Metodológica. 1999;7:1–14. Spanish.

  38. Kassirer JP, Cecil JS. Inconsistency in evidentiary standards for medical testimony: disorder in the courts. JAMA. 2002 Sep 18;288(11):1382–7.

  39. Pearce NA. Short Introduction to Epidemiology. Occasional Report Series No 2. Wellington (NZ): Centre for Public Health Research Massey University; 2003. 130 p.

  40. Denzin NK, Lincoln YS. Handbook of qualitative research. 2nd ed. London: Sage; 2000 Mar 18. 1143 p.

  41. Morgenstern H. Ecologic studies in epidemiology: concepts, principles, and methods. Ann Rev Public Health. 1995;16:61–81.

  42. Nuzzo R. P values, the ‘gold standard’ of statistical validity, are not as reliable as many scientists assume. Nature. 2014 Feb 12;506(7487):150–2.

  43. Silva LC. Una ceremonia estadística para identifi car factores de riesgo. Revista Salud Colectiva. 2005;1(3):309–22. Spanish.

  44. Höfl er M. Causal inference based on counterfactuals. BMC Med Res Methodol. 2005 Sep 13;5:28.

  45. Diez AV. Next steps in understanding the multilevel determinants of health. J Epidemiol Community Health. 2008 Nov;62(11):957–9.

  46. Williamson J. Bayesian nets and causality. Philosophical and Computational Foundations. Oxford: Oxford University Press; 2005 Feb 24. 250 p.

  47. Shrier I, Platt RW. Reducing bias through directed acyclic graphs. BMC Med Res Methodol. 2008 Oct 30;8:70.

  48. Kaur B, Khera A, Sandhir R. Attenuation of cellular antioxidant defense mechanisms in kidney of rats intoxicated with carbofuran. J Biochem Mol Toxicol. 2012 Oct;26(10):393–8.

  49. Li Q, Peng X, Yang H, Wang H, Shu Y. Defi ciency of multidrug and toxin extrusion 1 enhances renal accumulation of Paraquat and deteriorates kidney injury in mice. Mol Pharm. 2011 Dec 5;8(6):2476–83.

  50. Siddharth M, Datta SK, Bansal S, Mustafa M, Banerjee BD, Kalra OP, et al. Study on organochlorine pesticide levels in chronic kidney disease patients: association with estimated glomerular fi ltration rate and oxidative stress. J Biochem Mol Toxicol. 2012 Jun;26(6):241–7.

  51. Carson R. Silent Spring. Boston: Houghton Miffl in; 1962.

  52. Raffensperger C, Tickner J, editors. Public health and the environment: implementing the precautionary principle. Washington, DC: Island Press; 1999.

  53. United Nations Environment Program. Agenda 21, Rio Declaration on environment and development, and the statement of principles for the sustainable management of forests. United Nations Conference on Environment and Development (UNCED) [Internet]. Rio de Janeiro: United Nations Environment Program; 1992 Jun [cited 2014 Feb 6]; [about 4 p.]. Available from: http:// www.unep.org/Documents.Multilingual/Default .asp?documentid=78&articleid=1163

  54. Stockholm Convention [Internet]. Stockholm: Secretariat of Stockholm Convention; c2008 [cited 2014 Feb 6]. Available from: http://chm.pops .int/Countries/StatusofRatifications/Partiesand Signatories/tabid/252/Default.aspx

  55. Rosenthal E. Who’s afraid of national laws? Pesticide corporations use trade negotiations to avoid bans and undercut public health protections in Central America. Int J Occup Environ Health. 2005 Oct–Dec;11(4):437–43.

  56. Wesseling C, Corriols M, Bravo V. Acute pesticide poisoning and pesticide registration in Central America. Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):S697–705.

  57. Bravo V, Rodríguez T, van Wendel de Joode B, Canto N, Calderón GR, Turcios M, et al. Monitoring pesticide use and associated health hazards in Central America. Int J Occup Environ Health. 2011 Jul–Sep;17(3):258–69.

  58. elfaro.net [Internet]. San Salvador: elfaro; 2014. Entre los 11 pesticidas por los que aboga Funes hay nefrotóxicos y cancerígenos; 2013 Dec 9 [cited 2014 Mar 6]; [about 4 p.]. Available from: http://www.elfaro.net/es/201312/noticias/14070/. Spanish.




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