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2015, Número 2

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Rev Cubana Med Trop 2015; 67 (2)


Estrés oxidative-nitrosativo y dengue: revisión sistemática de estudios in vivo e in vitro

Castro OR, Pinzón-Redondo HS, Alvis-Guzmán NR

Idioma: Ingles.
Referencias bibliográficas: 54
Paginas: 244-263
Archivo PDF: 175.42 Kb.


RESUMEN

Objetivo: sistematizar las evidencias in vivo/in vitro de la participación del estrés oxidativo-nitrosativo en el curso de la infección por virus del dengue.
Métodos: revisión sistemática de estudios observacionales en las bases de datos (PubMed, EMBASE, The COCHRANE library, ScienceDirect, Scopus, SciELO, LILACS via Virtual Health Library, Google Scholar) utilizando las siguientes palabras clave: dengue, dengue virus, severe dengue, oxidative stress, nitrosative stress, antioxidants, oxidants, free radicals, oxidized lipid products, lipid peroxides, nitric oxide y nitric oxide synthase. La selección inicial fue realizada a partir del título y resumen excluyéndose: cartas para editor, revisiones, estudios con diseños epidemiológicos y estudios duplicados. A cada artículo seleccionado, se le revisó el objetivo o propósito, cultivos celulares o modelos animales utilizados, cepas víricas o tipo de anticuerpos utilizados, métodos y valores de los marcadores de estrés oxidativo-nitrosativo.
Resultados: de 4330 publicaciones encontradas, 32 estudios cumplieron con los criterios de inclusión. Se utilizaron primates no humanos y ratones knockout o tipo salvaje para la obtención de las evidencias in vivo. Los cultivos celulares más utilizados fueron de células mononucleares de sangre periférica y de células endoteliales humanas. Las cepas más utilizadas en los ensayos correspondieron al serotipo 2 del virus dengue.
Conclusiones: existen evidencias in vivo/in vitro que muestran la posible asociación entre el estrés oxidativo-nitrosativo con: producción de proteínas relacionadas con la patogénesis del dengue, incremento en la susceptibilidad de ratones por la infección por dengue, desarrollo de hemorragias en modelo de ratón, expresión de citoquinas proinflamatorias y replicación viral en varios cultivos de células tanto humanas como de origen animal.


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